- 基本信息
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导师姓名：
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王阳
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学科代码：
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100202
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性别：
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男
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学科名称：
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儿科学
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培养单位：
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附属新华医院
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三级学科
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导师类型：
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硕士生导师
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专业领域名称：
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联系方式：
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欢迎有志于探索肠神经系统奥秘的同学联系，请发Email至此邮箱：wangyangwy@shsmu.edu.cn
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专业领域代码：
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邮编：
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200092
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邮箱地址：
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wangyang@xinhuamed.com.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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国家自然科学基金委员会项目函评专家
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教育部研究生学位论文评审专家库专家
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美国哈佛大学医学院博士后
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中国生物化学与分子生物学会生物技术专业委员会委员
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上海市科学技术专家库专家
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Frontiers in Pharmacology杂志（IF=5.9879）国际编委会委员
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Frontiers in Genetics 杂志（IF=4.7722）国际编委会委员
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上海交通大学“SMC-晨星优秀青年教师” （2013年度、2017年度两次入选）
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上海高校优秀青年教师（2012年度）
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- 科研项目
| 22ZR1451500 | 上海市自然科学基金面上项目 | 上海市科学技术委员会科技创新行动计划 |
2022-04~2025-03
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20万元
| 课题负责人 |
| 201840028 | MicroRNA表达谱在先天性巨结肠临床早期诊断中的应用研究 | 上海市卫计委临床研究专项（面上项目） |
2019-01~2021-12
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10万元
| 课题负责人 |
| 81670469 | MiR-132介导巯基亚硝基化修饰在先天性巨结肠发生中的作用及其调控机制研究 | 国家自然科学基金面上项目 |
2017-01~2020-12
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58万元
| 课题负责人 |
| 81630039 | 肠道菌群失调对早产儿肠外营养相关肝损害作用及机制研究 | 国家自然科学基金（重点项目） |
2017-01~2021-12
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275万元
| 课题参与人 |
| 14X100010114 | 顺-反式调控效应在先天性巨结肠发生中的作用及其分子机制研究 | 上海交通大学“晨星优秀青年教师奖励计划” |
2013-12~2016-12
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8万元
| 课题负责人 |
| YG2012MS04 | 基因表达顺式调控机制在先天性巨结肠发生中的作用及其临床应用研究 | 上海交通大学医工交叉研究基金（面上项目） |
2013-01~2015-12
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15万元
| 课题负责人 |
| 81200259 | 先天性巨结肠相关Hedgehog及Notch信号通路的分子遗传机制研究 | 国家自然科学基金青年项目 |
2013-01~2015-12
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23万元
| 课题负责人 |
| ZZjdyx12094 | 等位基因特异性表达诱导先天性巨结肠发生的机制研究 | 上海高校优秀青年教师培养资助计划 |
2012-10~2014-09
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5万元
| 课题负责人 |
| 12XJ30067 | 顺式调控网络相关先天性巨结肠的机制研究 | 上海交通大学医学院科技基金 |
2012-06~2014-06
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5万元
| 课题负责人 |
- 学术论文
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Xu Z, Yan Y, Gu B, Cai W,
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Up-Regulation of microRNA-424 Causes an Imbalance in AKT Phosphorylation and Impairs Enteric Neural Crest Cell Migration in Hirschsprung Disease
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Int J Mol Sci
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2023
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24(7):6700
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Jiang Q,, Gao Y, Wang H, Zhang Z, Li Q, Xu S, Cai W, Li L.
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RET compound inheritance in Chinese patients with Hirschsprung disease: lack of penetrance from insufficient gene dysfunction.
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Hum Genet
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2021
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140(5):813-825
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, Jiang Q, Cai H, Xu Z, Wu W, Gu B, Li L, Cai W.
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Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease.
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Aging
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2020
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12(5):4379-4393
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, Jiang Q, Chakravarti A, Cai H, Xu Z, Wu W, Gu B, Li L, Cai W.
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MicroRNA-4516-mediated regulation of MAPK10 relies on 3' UTR cis-acting variants and contributes to the altered risk of Hirschsprung disease.
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J Med Genet
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2020
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57(9):634-642
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Jiang Q,, Li Q, Zhang Z, Xiao P, Wang H, Liu N, Wu J, Zhang F, Chakravarti A, Cai W, Li L.
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Sequence characterization of RET in 117 Chinese Hirschsprung disease families identifies a large burden of de novo and parental mosaic mutations.
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Orphanet J Rare Dis
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2019
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14(1):237
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, Yan W, Wang J, Zhou Y, Chen J, Gu B, Cai W.
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Common genetic variants in GAL, GAP43 and NRSN1 and interaction networks confer susceptibility to Hirschsprung disease.
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J Cell Mol Med
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2018
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22(7):3377-3387
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Dai LN, Yan JK, Xiao YT, Wen J, Zhang T, Zhou KJ,, Cai W.
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Butyrate stimulates the growth of human intestinal smooth muscle cells by activation of yes-associated protein.
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J Cell Physiol
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2018
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233(4):3119-3128
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Cheng S, Wang J, Pan W, Yan W, Shi J, Guan W,, Cai W.
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Pathologically assessed grade of Hirschsprung-associated enterocolitis in resected colon in children with Hirschsprung's disease predicts postoperative bowel function.
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J Pediatr Surg
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2017
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52(11):1776-1781
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Wei Z, Batagov AO, Schinelli S, Wang J,, El Fatimy R, Rabinovsky R, Balaj L, Chen CC, Hochberg F, Carter B, Breakefield XO, Krichevsky AM
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Coding and noncoding landscape of extracellular RNA released by human glioma stem cells
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Nat Commun
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2017
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8(1):1145
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, Veremeyko T, Wong AH, El Fatimy R, Wei Z, Cai W, Krichevsky AM.
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Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease.
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Neurobiol Aging
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2017
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51:156-166
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, Cao Y, Huang X, Yu T, Wei Z, McGrath J, Xu F, Bi Y, Li X, Yang F, Li W, Zou X, Peng Z, Xiao Y, Zhang Y, He L, He G.
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Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia.
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Sci Rep
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2016
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6:26688
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Teplyuk NM, Uhlmann EJ, Gabriely G, Volfovsky N,, Teng J, Karmali P, Marcusson E, Peter M, Mohan A, Kraytsberg Y, Cialic R, Chiocca EA, Godlewski J, Tannous B, Krichevsky AM.
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Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic.
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EMBO Mol Med
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2016
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8(3):268-87
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, Wang J, Zhou Y, Wei Z, Xiao Y, Zhou K, Wen J, Yan J, Cai W.
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Contribution of Common Variants in GABRG2, RELN and NRG3 and Interaction Networks to the Risk of Hirschsprung Disease.
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Cell Physiol Biochem
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2016
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40(3-4):509-526
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Xiao Y, Wang J, Yan W, Zhou Y, Chen Y, Zhou K, Wen J,, Cai W.
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Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling.
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J Hepatol
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2015
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62(4):889-96
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Chen Y1, Xiao Y, Ge W, Zhou K, Wen J, Yan W,, Wang B, Qu C, Wu J, Xu L, Cai W.
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miR-200b inhibits TGF-β1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells.
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Cell Death Dis
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2013
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4:e541
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, Wang J, Pan W, Zhou Y, Xiao Y, Zhou K, Wen J, Yu T, Cai W.
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Common genetic variations in Patched1 (PTCH1) gene and risk of hirschsprung disease in the Han Chinese population.
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PLoS One
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2013
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20;8(9):e75407
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Huang X,, Yu T, Liu B, Li X, Li W, Chen S, Zhao Q, Li X, Yang F, Wang Q, Wang J, Xiao Y, Xu Y, Feng G, Peng Z, He L, He G
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Association study of APC polymorphisms with colorectal cancer in Han Chinese.
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Clin Biochem
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2012
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45(18):1669-72
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, He G, He L, McGrath J.
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Do shared mechanisms underlying cell cycle regulation and synaptic plasticity underlie the reduced incidence of cancer in schizophrenia?
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Schizophr Res
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2011
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130(1-3):282-4
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Li J, Zhou G, Ji W, Feng G, Zhao Q, Liu J, Li T, Li Y, Chen P, Zeng Z, Wang T, Hu Z, Zheng L,, Shen Y, He L, Shi Y.
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Common variants in the BCL9 gene conferring risk of schizophrenia.
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Arch Gen Psychiatry
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2011
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68(3):232-40
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, Wang L, Li X, Liu B, Zhao Q, Chen P, Wang T, Li T, Ji J, Yang F, Wang Q, Wang J, Xiao Y, Xu Y, Feng G, Peng Z, He L, He G.
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Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients.
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BMC Cancer
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2010
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10:523.
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, Zhang J, Liu B, Shao L, Wei Z, Li X, Ji J, Yang F, Wang T, Liu J, Wan C, Li B, Xu Y, Feng G, He L, He G.
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Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population.
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World J Biol Psychiatry
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2010
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11(8):956-63
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, Zhang J, Li X, Ji J, Yang F, Wan C, Feng G, Wan P, He L, He G.
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SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population
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Prog Neuropsychopharmacol Biol Psychiatry
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2008
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32(8):1902-4
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