- 基本信息
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导师姓名：
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王兆军
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学科代码：
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100100
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性别：
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女
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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zjwang@sjtu.edu.cn
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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Zjwang@sjtu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 82272362 | PRL2在中性粒细胞胞外诱捕网形成及重症疟疾中的作用机制研究 | 国家自然科学基金面上项目 |
2023-01~2026-12
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52万元
| 课题负责人 |
| GWV-10.1-XK13 | 寄生虫病与病媒控制_寄生虫感染继发疾病的机制及诊疗靶标研究 | 上海市第五轮公共卫生体系建设三年行动计划重点学科项目 |
2020-07~2022-06
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20万元
| 子课题负责人 |
| 81971486 | PRL2调控固有免疫细胞活化及其在抗菌感染免疫中的作用机制 | 国家自然科学基金 |
2020-01~2023-12
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52万元
| 课题负责人 |
| 19ZR1428500 | PRL2调控活性氧及抗菌感染免疫应答的机制研究 | 上海市自然科学基金 |
2019-07~2022-06
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20万元
| 课题负责人 |
| 2016YFC1303300 | 基于组学特征的肺癌免疫治疗疗效预测指标的构建和验证 | 科技部“重大慢性非传染性疾病防控研究”重点专项(子课题) |
2017-09~2020-12
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127万元
| 课题参与人 |
| NSF-81471971 | 血吸虫虫卵16kD钙结合蛋白诱导巨噬细胞极化调控宿主免疫病理反应的机制研究 | 国家自然基金委,面上项目 |
2015-01~2018-12
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72万元
| 课题负责人 |
| 14PJ1406000 | 血吸虫SjE16抗原在巨噬细胞M1/M2极化中的作用及调控机制研究 | 上海市浦江人才计划(A类） |
2014-07~2016-06
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20万元
| 课题负责人 |
| NSF-81172808 | TIPE2-Rac信号通路在感染免疫中的作用与机理研究 | 国家自然基金委,面上项目 |
2012-01~2015-12
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55万元
| 课题负责人 |
| 201179 | TIPE2-Rac信号通路在感染免疫中的作用与机理研究 | 高等学校全国优秀博士学位论文作者专项资金 |
2011-01~2013-12
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30万元
| 课题负责人 |
| 08QA1404300 | 青蒿素类药物治疗病毒性心肌炎的作用及其机理研究 | 上海市科委,启明星 |
2008-07~2010-07
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15万元
| 课题负责人 |
| NSF-30600517 | 日本血吸虫特异性抗原调节自身免疫病的机理研究 | 国家自然基金委,面上项目 |
2007-01~2009-12
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23万元
| 课题负责人 |
| 06ZR14058 | 日本血吸虫特异性抗原调节自身免疫病的机理研究 | 上海市科委,自然基金 |
2006-09~2008-08
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8万元
| 课题负责人 |
- 学术论文
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Li Q,Yue T,Du X,Tang Z,Cui J,Wang W,Xia W,Ren B,Kan S,Li C,Wu C,Niu X,Li B,Lin K,Luo J,Chen G,,
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HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction
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Cell death and differentiation
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2022
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10
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Kan S.,Li Q., Li H.-M.,Yao Y.-H., Du X.-Y.,Wu C.-Y., Chen G.-J.,Guo X.-K., Qian M.-B.,
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Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex
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PLoS neglected tropical diseases
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2022
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16 (9)
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Wu C, Du X, Tang L, Wu J, Zhao W, Guo X, Liu D, Hu W, Helmby H, Chen G,
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Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE).
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Frontiers in immunology
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2020
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11, 1767
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Du X, Zhang Y,Li X, Li Q, Wu C,Chen G, Guo X, Weng Y,
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PRL2 serves as a negative regulator in cell adaptation to oxidative stress.
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Cell & bioscience
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2019
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9, 96.
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Lao Y, Yang K,, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ET, Yang J, Yi J
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DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages
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J Biol Chem
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2018
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93(11): 3965–3980
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Yin C, Wu C, Du X, Fang Y, Pu J, Wu J, Tang L, Zhao W, Weng Y, Guo X, Chen G,
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PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS.
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Frontiers in immunology
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2018
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9, 2609
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Fayngerts SA,, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH
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Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.
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Nature immunology
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2017
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18(12)1353-1360
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Niu X, Deng S, Li S, Xi Y, Li C, Wang L, He D,,Chen G
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Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells
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Molecular Medicine
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2016
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22:608-620
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Porturas TP, Sun H, Buchlis G, Lou Y, Liang X, Cathopoulis T, Fayngerts S,Johnson DS,, Chen YH.
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Crucial Roles of TNFAIP8 Protein in Regulating Apoptosis and Listeria Infection
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the Journal of Immunology
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2015
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194(12):5743-50
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Fang Y, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G,
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SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development
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Acta Tropica
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2015
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149:49-58
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Cheng W, Zhao Q, Xi Y, Li C, Xu Y, Wang L, Niu X,,Chen Z
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IFN-β inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis
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Molecular Immunology
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2015
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64(1):152-62
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Zhang Z, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H,, Chen YH, Ma C
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TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells
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Oncogene
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2015
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34(20)2566-74
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Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T,, Cui J,Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH.
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TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer
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Cancer Cell
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2014
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26(4):465-78
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Wu C, Chen Q, Fang Y, Wu J, Han Y, Wang Y, Yang Y, Chu M, Feng Y, Tan L, Guo X, Hu W,
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Schistosoma Japonicum Egg Specific Protein Sje16.7 Recruits Neutrophils and Induces Inflammatory Hepatic Granuloma Initiation
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PLoS Neglected Tropical Disease
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2014
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8(2): e2703
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Sun H, Zhuang G, Chai L,, Johnson D, Ma Y, Chen YH
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TIPE2 Controls Innate Immunity to RNA by Targeting the Phosphatidylinositol 3-Kinase-Rac Pathway.
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The Journal of Immunology
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2012
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189(6):2768-73
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, Fayngerts S, Wang P, Sun H, Johnson DS, Ruan Q, Guo W, Chen YH.
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TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection.
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Proc Natl Acad Sci U S A.
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2012
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109(38):15413-8
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Wu C, Feng Y, Qian G, Wu J, Luo J, Wang Y, Chen G, Guo X,
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a-Galactocylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis.
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Clinical and Experimental Immunology
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2010
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162:178-187
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Chen GJ, Hao J, Xi YB, Wang W,, Li NL & Li WY.
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The Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Arthritis is Associated with CD4+CD25+ T Regulatory Cells.
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Scandinavian Journal of Immunology
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2008
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68(6): 572–578.
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, Ju Qiu, Taylor B Guo, Ailian Liu, Ying Wang, Yin Li, Jingwu Z Zhang.
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Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis.
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The Journal of Immunology
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2007
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179（9）:5958-5965
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, Jian Hong, Wei Sun, Guangwu Xu, Ningli Li, Xi Chen, Ailian Liu, Lingyun Xu, Bing Sun, Jingwu Z Zhang.
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Role of gamma-interferon in induction of Foxp3 and conversion of CD4+CD25- T cells to CD4+regulatory T cells.
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The Journal of Clinical Investigation
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2006
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116(9):2434-2441.
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Hu W, Yan Q, Shen DK, Liu F, Zhu ZD, Song HD, Xu XR,, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, Zhang XL, Wang ZQ, Brindley, PJ, McManus, DP, Xue CL, Feng Z, Chen Z, Han ZG,
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Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource.
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Nature Genetics
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2003
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35(2):139-147
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