• 基本信息
    导师姓名: 王兆军 学科代码: 100100
    性别: 学科名称: 基础医学
    培养单位: 基础医学院 三级学科
    导师类型: 博士生导师 专业领域名称:
    联系方式: zjwang@sjtu.edu.cn 专业领域代码:
    邮编: 200025 邮箱地址: Zjwang@sjtu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    GWV-10.1-XK13寄生虫病与病媒控制_寄生虫感染继发疾病的机制及诊疗靶标研究上海市第五轮公共卫生体系建设三年行动计划重点学科项目 2020-07~2022-06 20万元  子课题负责人
    81971486PRL2调控固有免疫细胞活化及其在抗菌感染免疫中的作用机制国家自然科学基金 2020-01~2023-12 52万元  课题负责人
    19ZR1428500PRL2调控活性氧及抗菌感染免疫应答的机制研究上海市自然科学基金 2019-07~2022-06 20万元  课题负责人
    2016YFC1303300基于组学特征的肺癌免疫治疗疗效预测指标的构建和验证科技部“重大慢性非传染性疾病防控研究”重点专项(子课题) 2017-09~2020-12 127万元  课题参与人
    NSF-81471971血吸虫虫卵16kD钙结合蛋白诱导巨噬细胞极化调控宿主免疫病理反应的机制研究国家自然基金委,面上项目 2015-01~2018-12 72万元  课题负责人
    14PJ1406000血吸虫SjE16抗原在巨噬细胞M1/M2极化中的作用及调控机制研究上海市浦江人才计划(A类) 2014-07~2016-06 20万元  课题负责人
    NSF-81172808TIPE2-Rac信号通路在感染免疫中的作用与机理研究国家自然基金委,面上项目 2012-01~2015-12 55万元  课题负责人
    201179TIPE2-Rac信号通路在感染免疫中的作用与机理研究高等学校全国优秀博士学位论文作者专项资金 2011-01~2013-12 30万元  课题负责人
    08QA1404300青蒿素类药物治疗病毒性心肌炎的作用及其机理研究上海市科委,启明星 2008-07~2010-07 15万元  课题负责人
    NSF-30600517日本血吸虫特异性抗原调节自身免疫病的机理研究国家自然基金委,面上项目 2007-01~2009-12 23万元  课题负责人
    06ZR14058日本血吸虫特异性抗原调节自身免疫病的机理研究上海市科委,自然基金 2006-09~2008-08 8万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Wu C, Du X, Tang L, Wu J, Zhao W, Guo X, Liu D, Hu W, Helmby H, Chen G,  Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE).  Frontiers in immunology  2020  11, 1767 
    Du X, Zhang Y,Li X, Li Q, Wu C,Chen G, Guo X, Weng Y,  PRL2 serves as a negative regulator in cell adaptation to oxidative stress.  Cell & bioscience  2019  9, 96. 
    Lao Y, Yang K,, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ET, Yang J, Yi J   DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages  J Biol Chem  2018  93(11): 3965–3980 
    Yin C, Wu C, Du X, Fang Y, Pu J, Wu J, Tang L, Zhao W, Weng Y, Guo X, Chen G,  PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS.  Frontiers in immunology  2018  9, 2609 
    Fayngerts SA,, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH   Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.  Nature immunology   2017  18(12)1353-1360 
    Niu X, Deng S, Li S, Xi Y, Li C, Wang L, He D,,Chen G  Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells  Molecular Medicine  2016  22:608-620 
    Porturas TP, Sun H, Buchlis G, Lou Y, Liang X, Cathopoulis T, Fayngerts S,Johnson DS,, Chen YH.  Crucial Roles of TNFAIP8 Protein in Regulating Apoptosis and Listeria Infection  the Journal of Immunology  2015  194(12):5743-50 
    Fang Y, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G,  SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development  Acta Tropica  2015  149:49-58 
    Cheng W, Zhao Q, Xi Y, Li C, Xu Y, Wang L, Niu X,,Chen Z  IFN-β inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis  Molecular Immunology  2015  64(1):152-62 
    Zhang Z, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H,, Chen YH, Ma C  TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells  Oncogene  2015  34(20)2566-74 
    Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T,, Cui J,Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH.  TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer  Cancer Cell  2014  26(4):465-78 
    Wu C, Chen Q, Fang Y, Wu J, Han Y, Wang Y, Yang Y, Chu M, Feng Y, Tan L, Guo X, Hu W,  Schistosoma Japonicum Egg Specific Protein Sje16.7 Recruits Neutrophils and Induces Inflammatory Hepatic Granuloma Initiation  PLoS Neglected Tropical Disease  2014  8(2): e2703 
    Sun H, Zhuang G, Chai L,, Johnson D, Ma Y, Chen YH  TIPE2 Controls Innate Immunity to RNA by Targeting the Phosphatidylinositol 3-Kinase-Rac Pathway.  The Journal of Immunology  2012  189(6):2768-73 
    , Fayngerts S, Wang P, Sun H, Johnson DS, Ruan Q, Guo W, Chen YH.   TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection.  Proc Natl Acad Sci U S A.  2012  109(38):15413-8 
    Wu C, Feng Y, Qian G, Wu J, Luo J, Wang Y, Chen G, Guo X,  a-Galactocylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis.  Clinical and Experimental Immunology  2010  162:178-187 
    Chen GJ, Hao J, Xi YB, Wang W,, Li NL & Li WY.  The Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Arthritis is Associated with CD4+CD25+ T Regulatory Cells.   Scandinavian Journal of Immunology  2008  68(6): 572–578. 
    , Ju Qiu, Taylor B Guo, Ailian Liu, Ying Wang, Yin Li, Jingwu Z Zhang.  Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis.  The Journal of Immunology  2007  179(9):5958-5965 
    , Jian Hong, Wei Sun, Guangwu Xu, Ningli Li, Xi Chen, Ailian Liu, Lingyun Xu, Bing Sun, Jingwu Z Zhang.  Role of gamma-interferon in induction of Foxp3 and conversion of CD4+CD25- T cells to CD4+regulatory T cells.  The Journal of Clinical Investigation  2006  116(9):2434-2441. 
    Hu W, Yan Q, Shen DK, Liu F, Zhu ZD, Song HD, Xu XR,, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, Zhang XL, Wang ZQ, Brindley, PJ, McManus, DP, Xue CL, Feng Z, Chen Z, Han ZG,  Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource.  Nature Genetics  2003  35(2):139-147