• 基本信息
    导师姓名： 张箴波 学科代码： 100211
    性别： 男 学科名称： 妇产科学
    培养单位： 附属第一人民医院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： 上海交通大学附属第一人民医院辅助生殖中心 专业领域代码：
    邮编： 200080 邮箱地址： zhangzhenbozzb@shsmu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    辅助生殖中心副主任兼胚胎实验室主任
    上海市医学会生殖医学分会委员
    上海市优秀学术带头人
    上海市松江区领军人才
    妇产临床医学中心副主任
    上海市中西医结合生殖内分泌学会委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    1超微量单精子冻存载体和配套技术的辅助生殖临床应用研发市一医院-微创联合项目 2021-05~2023-05 20万元  课题负责人
    TM020单精子辅助生殖治疗技术的研发上海市转化医学协同创新中心 2021-01~2022-12 10万元  课题负责人
    1中医药联合辅助生殖技术治疗不孕症研究上海市科委多中心临床研究项目 2021-01~2023-12 10万元  课题负责人
    2019121辅助生殖保留生育功能治疗研究上海市人才发展基金 2020-01~2023-01 30万元  课题负责人
    SQ2019YFC100003生殖健康及重大出生缺陷防控研究-妇科肿瘤患者保留生育功能相关技术研发科技部国家重点专项 2019-12~2022-12 70万元  子课题负责人
    1上海市松江区科技创新项目松江区科委 2019-05~2022-06 3万元  课题负责人
    19XD1423100子宫内膜增生性疾病孕激素耐药的分子机制及序贯辅助生殖治疗上海市优秀学术带头人计划 2019-05~2022-05 40万元  课题负责人
    81872111Brusatol 通过去羟甲基化修饰抑制Nrf2/ IDH1介导的能量代谢途径逆转I型子宫内膜癌孕激素耐药的分子机制国家自然科学基金面上项目 2019-01~2022-12 57万元  课题负责人
    暂无辅助生殖技术-胚胎发育机制研究上海交通大学附属上海市第一人民医院“卓越医师A类” 2019-01~2021-12 50万元  课题负责人
    20181714子宫内膜增生性疾病的辅助生殖治疗及研究上海市教委-上海交通大学高峰高原双百人计划 2018-09~2021-10 100万元  课题负责人
    81672562二甲双胍经泛素化降解Nrf2/AKR1C1通路逆转子宫内膜癌癌孕激素耐药国家自然科学基金面上项目 2017-01~2020-12 64万元  课题负责人
    YG2016MS27稀少精子冻存体系的建立及其分子机制上海交通大学医工交叉面上项目 2016-11~2018-10 21万元  课题负责人
    1妇产国家临床重点专科子项目卫生部 2015-05~2018-05 8万元  课题负责人
    暂无长链非编码RNA在妇科肿瘤中的作用机制上海交通大学晨星计划 2014-01~2018-12 20万元  课题负责人
    QY119长链非编码RNA靶向miRNAs调控子宫内膜癌OCT4表达的分子机制上海市卫生局 2014-01~2018-12 60万元  课题负责人
    81370074GloI基因DNA羟甲基化调控介导二甲双胍逆转子宫内膜癌孕激素耐药的分子机制国家自然科学基金青年转面上连续资助项目 2014-01~2017-12 80万元  课题负责人
    81210108021二甲双胍逆转子宫内膜癌孕激素耐药的分子机制国家自然科学基金国际合作项目 2012-06~2012-12 25万元  课题负责人
    暂无上海交通大学医学院潜力学科项目（PI:丰有吉）上海交通大学医学院 2012-01~2015-12 240万元  课题参与人
    81001155GloI介导子宫内膜癌孕激素耐药的分子机制国家自然科学基金青年基金 2012-01~2013-12 21万元  课题负责人
    2013子宫内膜癌保留生育功能的分子机制上海交通大学医学院“新百人”计划 2012-01~2014-01 15万元  课题负责人
    81020108027卵泡刺激素（FSH）对卵巢癌生长及转移的正调节作用国家自然科学基金重大国际合作项目 2011-01~2013-12 200万元  课题参与人
    81272883高迁移率族蛋白（HMG2L1，Sox2）介导FSH促卵巢癌细胞生长与转移作用及其分子机制研究国家自然科学基金 2010-01~2015-12 80万元  课题参与人
    暂无肥胖相关基因FTO在子宫内膜癌发生发展中的作用机制.上海市卫生局 2010-01~2013-01 4万元  课题负责人
    30872755FSH诱导上皮性卵巢癌VEGF表达的特殊信号通路的研究（PI:丰有吉）国家自然科学面上项目 2008-01~2011-12 33万元  课题参与人
    2015ZD001卵巢癌早期诊断及治疗新技术临床多中心研究（PI:丰有吉）上海市卫生局 2006-07~2008-07 100万元  课题参与人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Meiyan Hu, Di Sun,  Brusatol Sensitizes Endometrial Cancer to Progestin by Suppressing Nrf2-Tet1-AKR1C1-mediated Progestin Metabolism  Lab investigation  2022  Accept 
    Liqun Lou, Yisong Xu, Mu Lv, Juanjuan Yu, Qimeng Xiao, Peiqin Chen, Mingzhu Bai,  Mildly Stimulated Cycle with Letrozole Compared with Natural Cycle and HRT Cycle in Patients undergoing FET with Normal Ovulation Reproductive BioMedicine Online  Reproductive BioMedicine Online  2022  Accept 
    Wenju?Zhou;?Talha?Ouafa;?Yuan?Xu;?Rongfei?Chen;?Zhenbo?Zhang**.  Embryo?Evaluation?Based?on?Residual?Neural?Network?Optimized?by?Adaptive?Genetic?Algorithm  Journal of internet technology  2022  Accept-(应用AI的算法评估胚胎的质量) 
    Xiao Q, Liu Y, Jiang G, Liu Y, Huang Y, Liu W,  Heteroleptic Gold(I)-bisNHC complex with excellent activity in vitro, ex vivo and in vivo against endometrial cancer  Eur J Med Chem  2022  Jun 5;236:114302 
    Sun D, Qin Z, Xu Y, Xiao Q, Xu Y, Bai M, Li W, Liu Y, Zheng W,  The IVF-generated human embryonic microenvironment reverses progestin resistance in endometrial cancer cells by inducing cancer stem cell differentiation  Cancer Lett   2022  526:311-321 
    Lou L, Kong S, Sun Y,, Wang H.  Human Endometrial Organoids: Recent Research Progress and Potential Applications   Front Cell Dev Biol  2022  Feb 15;10:844623 
    Chao Li ,, Yixia Yang , Hong Liao   Changes in the cervicovaginal microbiota composition of HPV16-infected patients after clinical treatment  Cancer Med .  2022  May 15. doi: 10.1002/cam4.4801 
    万小平,陈晓军,王华英,,丰有吉  基于发病新机制的子宫内膜癌保留生育功能新策略  上海市医学科技一等奖  2021  1 
    Yang B, Hu M, Fu Y, Sun D, Zheng W, Liao H,, Chen X  LASS2 mediates Nrf2-driven progestin resistance in endometrial cancer  Am J Transl Res  2021  2021 Mar 15;13(3):1280-1289 
    Sun D, Bai M, Jiang Y, Hu M, Wu S, Zheng W,  Roles of follicle stimulating hormone and its receptor in human metabolic diseases and cancer  Am J Transl Res.  2020  12(7):3116-3132 
    Chen W, Bai MZ, Yang Y, Sun D, Wu S, Sun J, Wu Y, Feng Y, Wei Y, Chen Z,  ART strategies in Klinefelter syndrome   J Assist Reprod Genet （克氏综合症辅助生殖治疗规范））  2020  doi: 10.1007/s10815-020-01818-2.  
    Zhang C, Yang Y, Chen R, Wei Y, Feng Y, Zheng W, Liao H,  Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients.  Am J Transl Res.  2019  11(1):269-279 
    陈威,孙健,  一种高效安全的人稀少精子DPV冷冻系统及冷冻方  发明专利（专利号：2. ZL 2016 1 0396509.1）  2019  1-2 
    Jiang Y, Chen X, Wei Y, Feng Y, Zheng W,  Metformin sensitizes endometrial cancer cells to progestin by targeting TET1 to downregulate glyoxalase I expression.  Biomed Pharmacother  2019  5;113:108712. 
    Xu Y, Sun D, Chen W, Sun J, Yang Y, Wu Y, Li Z,  Severe Teratozoospermia Associated with Severe Oligospermia Affect Clinical Outcome in Human ICSI Cycles  Int J Clin Exp Med  2019  12(7):9324-9334 
    ZhangW; Yang, Chuang; Lei, Ziyu; Guan, Guoqiang; He, Shu-ang; Zhang,, Rujia; Shen, Hao; Hu, Junqing  A new strategy for specific eradication of implant-related infections based on special and selective degradability of rhenium trioxide nanocubes  ACS Applied Materials & Interfaces  2019  1-2 
    Bai M, Yang L, Liao H, Liang X, Xie B, Xiong J, Tao X, Chen X, Cheng Y, Chen X, Feng Y,, Zheng W.  Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism.  oncogene （IF：7.9）  2018  37(42):5666-5681 
    张箴波（3）  子宫内膜癌及癌前病变保留生育功能的临床-基础转化研究及应用  1. 2018年度上海市医学科技奖三等奖  2018  1 
    ,陈威,孙健等  一种高效安全的人稀少精子DPV冷冻系统-单精子治疗体系  实用新型专利 (专利号：ZL 2016 2 0544372.5)  2017  1-2 
    Linlin Yang, Qiaoying Lv, Wei Chen, Jian sun, Yu Wu, Yiying Wang, Xiong Chen, Xiaojun Chen,  Presence of embryonic DNA in culture medium  Oncotarget  2017  8(40):67805-67809 
    Lv QY, Xie BY, Yang BY, Ning CC, Shan WW, Gu C, Luo XZ, Chen XJ,, Feng YJ.  Increased TET1 Expression in Inflammatory Microenvironment of Hyperinsulinemia Enhances the Response of Endometrial Cancer to Estrogen by Epigenetic Modulation of GPER.  J Cancer  2017  Mar 12;8(5):894-902 
    Jian sun, Wei che, Minzhu Bai,, Yu Wu, Zheng Li  Successful Pregnancy Derived from Cryopreserved Rare Human Spermatozoa with Novel Cryo-piece through Intracytoplasmic Sperm Injection  Andrology  2017  5(4):832-837 
    Yiying Wang, Yue Wang,, Ji-Young Park, Donghui Guo, Hong Liao, Xiaofang Yi, Yu Zheng, Donna Zhang, Setsuko K. Chambers and Wenxin Zheng  Mechanism of Progestin Resistance in Endometrial Precancer/Cancer through Nrf2-AKR1C1 Pathway  Oncotarget  2016  1-12 
    Ning C, Xie B, Zhang L, Li C, Shan W, Yang B, Luo X, Gu C, He Q, Jin H, Chen X,, Feng Y.  Infiltrating macrophages induce ERα expression through an IL-17A-mediated epigenetic mechanism to sensitize endometrial cancer cells to estrogen.  Cancer Research (IF:9.3)  2016  1-12 
    Liao Hong, Yang binlie,  The Variants of Human Papillomavirus Type 16 Predispose toward Persistent infection.   Int J Clin Exp Pathol (IF:1.6)  2015  accept 
    W. Shan, C. Wang,, X. Luo, C. Ning, Y. Yu, Y. Feng, C. Gu, and X. Chen  Atm May Be a Protective Factor in Endometrial Carcinogenesis with the Progesterone Pathway  Tumour Biol  2015  36 (2015), 1529-37 
    Wang Y, Liao H, Zheng HC, LiL, Jia L,, Zheng W  Effect of luteinizing hormone-induced prohibitin and matrix metalloproteinases on ovarian epithelial tumor cell proliferation  Am J Cancer Res (IF: 4.2)  2015  5(1):114-24 
    L. Liu, J. Zhang, C. Fang,, Y. Feng, and X. Xi  'Oct4 Mediates Fsh-Induced Epithelial-Mesenchymal Transition and Invasion through the Erk1/2 Signaling Pathway in Epithelial Ovarian Cancer  Biochem Biophys Res Commun  2015  461 (2015), 525-32 
    M. Bai, M. Yuan, H. Liao, J. Chen, B. Xie, D. Yan, X. Xi, X. Xu,, and Y. Feng  Oct4 Pseudogene 5 Upregulates Oct4 Expression to Promote Proliferation by Competing with Mir-145 in Endometrial Carcinoma   Oncol Rep  2015  33 (2015), 1745-52 
    Chen Jiazhou, Bai mingzhu, Feng youji,, Zheng wenxin  Gankyrin Facilitates Follicle Stimulating Hormone-Driven Ovarian Cancer Cell Proliferation through the PI3K/AKT/HIF-1α/Cyclin D1 Pathway  Oncogene (IF: 8.5)  2015  accepted 
    L. Bao, M. C. Jaramillo,, Y. Zheng, M. Yao, D. D. Zhang, and X. Yi,  'Induction of Autophagy Contributes to Cisplatin Resistance in Human Ovarian Cancer Cells  Mol Med Rep  2015  11 (2015), 91-8. 
    Y. Liu, J. Zhang, W. Qian, Y. Dong, Y. Yang, Z. Liu, Y. Feng, D. Ma,, and S. Wu  Gankyrin Is Frequently Overexpressed in Cervical High Grade Disease and Is Associated with Cervical Carcinogenesis and Metastasis  plos one (IF: 3.6)  2014  e99594 
    W. Shan, C. Wang,, C. Gu, C. Ning, X. Luo, Q. Zhou, and X. Chen  Conservative Therapy with Metformin Plus Megestrol Acetate for Endometrial Atypical Hyperplasia  J Gynecol Oncol  2014  25 (2014), 214-20 
    Bao LJ, Jaramillo MC,, Zheng YX, Yao M, Zhang DD, Yi XF.  Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma.   Int J Clin Exp Patholo  2014  7 (4): 1502-1513 
    X. Wang, X. Ji, J. Chen, D. Yan,, Q. Wang, X. Xi, and Y. Feng  Sox2 Enhances the Migration and Invasion of Ovarian Cancer Cells Via Src Kinase'  PLoS One  2014  9 (2014), e99594 
    W. Shan, C. Ning, X. Luo, Q. Zhou, C. Gu,, and X. Chen  Hyperinsulinemia Is Associated with Endometrial Hyperplasia and Disordered Proliferative Endometrium: A Prospective Cross-Sectional Study  Gynecol Oncol  2014  132 (2014), 606-10. 
    Y. Yang, J. Zhang, Y. Zhu,, H. Sun, and Y. Feng  Follicle-Stimulating Hormone Induced Epithelial-Mesenchymal Transition of Epithelial Ovarian Cancer Cells through Follicle-Stimulating Hormone Receptor Pi3k/Akt-Snail Signaling Pathway  Int J Gynecol Cancer  2014  24 (2014), 1564-74 
    , Q. Wang, J. Ma, X. Yi, Y. Zhu, X. Xi, Y. Feng, and Z.   JinReactive Oxygen Species Regulate Fsh-Induced Expression of Vascular Endothelial Growth Factor Via Nrf2 and Hif1alpha Signaling in Human Epithelial Ovarian Cancer  Oncol Rep  2013  29 (2013), 1429-34 
    Wu SF, Qian WY,, Zhu YP, Feng YJ.  Network motifs in the transcriptional regulation network of cervical carcinoma cells respond to EGF.  Arch Gynecol Obstet.  2013  287(4):771-7. 
    Zhang J, Yang Y,, He Y, Liu Z, Yu Y, Wu S, Cai B, Feng Y.  Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway  cancer letters (IF: 5.99)  2013  339 (2):279-87 
    , Y. Zhu, Y. Lai, X. Wu, Z. Feng, Y. Yu, R. C. Bast, Jr., X. Wan, X. Xi, and Y. Feng,   Follicle-Stimulating Hormone Inhibits Apoptosis in Ovarian Cancer Cells by Regulating the Oct4 Stem Cell Signaling Pathway  Int J Oncol  2013  43 (2013), 1194-204 
    Tao X, Jin H,, Feng Y  Follicle-stimulating hormone enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3.  Endocr Relat Cancer. (IF: 5.6)  2013  20(3):415-29 
    Y. Lai, X. Zhang,, Y. Shu, X. Luo, Y. Yang, X. Wang, G. Yang, L. Li, and Y. Feng  The Microrna-27a: Zbtb10-Specificity Protein Pathway Is Involved in Follicle Stimulating Hormone-Induced Vegf, Cox2 and Survivin Expression in Ovarian Epithelial Cancer Cells  Int J Oncol  2013  42 (2013), 776-84 
    X. Wu, X. Xi, Q. Yan,, B. Cai, W. Lu, and X. Wan  Microrna-361-5p Facilitates Cervical Cancer Progression through Mediation of Epithelial-to-Mesenchymal Transition  Med Oncol  2013  30 (2013), 751 
    Y. Wei,, H. Liao, L. Wu, X. Wu, D. Zhou, X. Xi, Y. Zhu, and Y. Feng  Nuclear Estrogen Receptor-Mediated Notch Signaling and Gpr30-Mediated Pi3k/Akt Signaling in the Regulation of Endometrial Cancer Cell Proliferation  Oncol Rep  2012  27 (2012), 504-10. 
    X. Wu, Q. Yan,, G. Du, and X. Wan  Acrp30 Inhibits Leptin-Induced Metastasis by Downregulating the Jak/Stat3 Pathway Via Ampk Activation in Aggressive Spec-2 Endometrial Cancer Cells  Oncol Rep  2012  27 (2012), 1488-96 
    , Zhou D, Lai Y, Liu Y, Tao X, Wang Q, Zhao G, Gu H, Liao H, Zhu Y, Xi X, Feng Y  Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways.  cancer letters (IF: 5.99)  2012  319(1):89-97 
    H. Liao, Q. Zhou,, Q. Wang, Y. Sun, X. Yi, and Y. Feng  Nrf2 Is Overexpressed in Ovarian Epithelial Carcinoma and Is Regulated by Gonadotrophin and Sex-Steroid Hormones  Oncol Rep,   2012  27 (2012), 1918-24 
    L. Dong, Q. Zhou,, Y. Zhu, T. Duan, and Y. Feng  'Metformin Sensitizes Endometrial Cancer Cells to Chemotherapy by Repressing Glyoxalase I Expression  J Obstet Gynaecol Res  2012  38 (2012), 1077-85 
    Wu SF, Zhang JW, Qian WY,, Zhu YP, Feng YJ  Altered expression of survivin, Fas and FasL contributed to cervical cancer development and metastasis.   Eur Rev Med Pharmacol Sci.  2012  16(15):2044-50. 
    , L. Dong, L. Sui, Y. Yang, X. Liu, Y. Yu, Y. Zhu, and Y. Feng,  Metformin Reverses Progestin Resistance in Endometrial Cancer Cells by Downregulating Gloi Expression  Int J Gynecol Cancer  2011  21 (2011), 213-21 
    Jia lin, Yi xiaofang,, Kong beihua, Zheng wenxin  Prohibitin as a novel target protein of luteinizing hormone in ovarian epithelial carcinogenesis  Neoplasa  2011  58(2):104-9 
    , H. Liao, X. Chen, Y. Zheng, Y. Liu, X. Tao, C. Gu, L. Dong, T. Duan, Y. Yang, X. Liu, Y. Yu, and Y. Feng  Luteinizing Hormone Upregulates Survivin and Inhibits Apoptosis in Ovarian Epithelial Tumors  Eur J Obstet Gynecol Reprod Biol  2011  155 (2011), 69-74 
    C. Gu,, Y. Yu, Y. Liu, F. Zhao, L. Yin, Y. Feng, and X. Chen  Inhibiting the Pi3k/Akt Pathway Reversed Progestin Resistance in Endometrial Cancer  Cancer Sci (IF: 3.3)  2011  102 (2011), 557-64 
    Chen X,, Feng Y, Fadare O, Wang J, Ai Z, Jin H, Gu C, Zheng W, et al.   Aberrant survivin expression in endometrial hyperplasia: another mechanism of progestin resistance  Modern pathology (IF: 6.4)  2009  22(5):699-708 
    , Jia L, Feng Y, Zheng W  Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer  cancer letters (IF: 5.99)  2009  278(1):56-64