- 基本信息
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导师姓名：
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孙宇
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学科代码：
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071000
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性别：
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男
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学科名称：
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生物学
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培养单位：
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健康科学研究所
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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中国科学院上海生命科学研究院&
上海交通大学医学院健康科学研究所
上海市徐汇区岳阳路320号
生命科学实验大楼A座1526室
电话：+86-21-54923302
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专业领域代码：
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邮编：
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200031
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邮箱地址：
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sunyu@sibs.ac.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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CSC, JBC, EMBO J, Cancer Cell, Nature Cell Biol审稿人.
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ASCB, AACR, IUBMB，CSBMCB会员。美国国防部研究员(PI)。
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- 科研项目
| 81472709 | 放化疗条件下基质细胞DNA损伤分泌程序的分子调控机制和对癌症复发、转移的功能性影响 | 国家自然科学基金面上项目 |
2015-01~2018-12
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105万元
| 课题负责人 |
| 11XJ21026 | 科学院创新经费 | 健康所 |
2014-01~2016-12
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240万元
| 课题负责人 |
| | 青年千人计划 | 中组部 |
2014-01~2016-12
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200万元
| 主要责任人 |
- 学术论文
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, Zhu D, Chen F, Qian M, Wei H, Chen W, Xu J.
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SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment
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Oncogene
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2016
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Epub ahead of print
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Xu Q, Chiao P,
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Amphiregulin in cancer: new insights for translational medicine
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Trends in Cancer
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2016
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2: 111-113.
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Tumor Microenvironment and Cancer Therapy Resistance
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Cancer Lett
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2015
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pii: S0304-3835(15)00512-1
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Translational Horizons in the Tumor Microenvironment: Harnessing Breakthroughs and Targeting Cures
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Med. Res. Rev.
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2015
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35: 408-436
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Zhang B,
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Targeting of the Angpt-Tie System in Current Anticancer Therapy
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Translational Medicine
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2015
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Epub ahead of print
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Laberge RM,, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell, KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez, PY, Benz, CC, Kapahi P, Nelson PS, Campisi J.
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mTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
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Nature Cell Biology
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2015
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17: 1049-1061
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Chen F, Qi X, Qian, M,, Sun Y
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Tackling the Tumor Microenvironment: What Challenge Does It Pose to Anticancer Therapies?
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Protein Cell
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2014
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5: 816–826.
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, Campisi J, Higano C, Beer TM, Porter P, Coleman I, True L, Nelson PS.
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Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
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Nature Medicine
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2012
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18(9):1359-68.
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, Nelson PS.
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Molecular pathways: involving microenvironment damage responses in cancer therapy resistance.
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Clinical Cancer Research
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2012
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18(15):4019-25.
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Bluemn EG, Paulson KG, Higgins EE,, Nghiem P, Nelson PS.
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Merkel cell polyomavirus is not detected in prostate cancers, surrounding stroma, or benign prostate controls.
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Journal of Clinical Virology
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2009
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44(2):164-6.
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, Wong N, Guan Y, Salamanca CM, Cheng JC, Lee JM, Gray JW, Auersperg N.
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The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas.
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International journal of cancer
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2008
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123(8):1761-9.
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Coppé JP, Patil CK, Rodier F,, Mu?oz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J.
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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
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PLoS Biology
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2008
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6(12):2853-68
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Li P, Maines-Bandiera S, Kuo WL, Guan Y,, Hills M, Huang G, Collins CC, Leung PC, Gray JW, Auersperg N.
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Multiple roles of the candidate oncogene ZNF217 in ovarian epithelial neoplastic progression.
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International journal of cancer
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2007
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120(9):1863-73.
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, Bojikova-Fournier S, MacRae TH.
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Structural and functional roles for beta-strand 7 in the alpha-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana.
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The FEBS journal
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2006
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273(5):1020-34.
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Villeneuve TS1, Ma X,, Oulton MM, Oliver AE, MacRae TH.
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Inhibition of apoptosis by p26: implications for small heat shock protein function during Artemia development.
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Cell stress & chaperones
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2006
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11(1):71-80.
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Ma X1, Jamil K, Macrae TH, Clegg JS, Russell JM, Villeneuve TS, Euloth M,, Crowe JH, Tablin F, Oliver AE.
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A small stress protein acts synergistically with trehalose to confer desiccation tolerance on mammalian cells.
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Cryobiology
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2005
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51(1):15-28.
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, MacRae TH.
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The small heat shock proteins and their role in human disease.
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The FEBS journal.
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2005
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272(11):2613-27.
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, MacRae TH.
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Characterization of novel sequence motifs within N- and C-terminal extensions of p26, a small heat shock protein from Artemia franciscana.
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The FEBS journal
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2005
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272(20):5230-43.
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, MacRae TH.
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Small heat shock proteins: molecular structure and chaperone function.
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Cellular and Molecular life sciences
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2005
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62(21):2460-76.
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, Mansour M, Crack JA, Gass GL, MacRae TH.
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Oligomerization, chaperone activity, and nuclear localization of p26, a small heat shock protein from Artemia franciscana.
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The Journal of biological chemistry
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2004
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279(38):39999-40006.
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Crack JA, Mansour M,, MacRae TH.
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Functional analysis of a small heat shock/alpha-crystallin protein from Artemia franciscana. Oligomerization and thermotolerance.
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The Journal of biological chemistry
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2002
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269(3):933-42.
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