- 基本信息
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导师姓名：
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陈广洁
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学科代码：
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100100
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性别：
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女
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海市重庆南路280号5号楼908室
邮箱：chenguangjie@sjtu.edu.cn, guangjie_chen@163.com
办公室电话：021-63846590-776665
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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chenguangjie@sjtu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 81771731 | 关节滑膜肥大细胞的区域免疫特性及其介导的Th17活化和相互作用在类风湿关节炎发病中的研究 | 国家自然科学基金，面上项目 |
2018-01~2021-10
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55万元
| 课题负责人 |
| 81373208 | IFN-β调控OPN/Th17炎性通路在多发性硬化中的机理研究 | 国家自然科学基金 |
2014-01~2017-12
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70万元
| 课题负责人 |
| 2011177 | β-干扰素对多发性硬化的免疫调节机制研究 | 卫生局科技发展基金 |
2012-01~2012-12
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3万元
| 课题负责人 |
| 12ZZ103 | IFN-β恢复多发性硬化IFN-β在实验性自身免疫性脑脊髓炎中的免疫调节机制研究 | 上海市教委科研创新(重点) |
2012-01~2014-12
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16万元
| 课题负责人 |
| 11JC1411602 | IFN-β恢复多发性硬化Treg/Th17平衡作用机制的研究 | 上海市科委基础研究重点项目 |
2012-01~2014-12
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15万元
| 课题负责人 |
| 30972743 | 免疫活性肽段ergotype在类风湿关节炎中的免疫调节作用研究 | 国家自然基金，面上项目 |
2010-01~2012-12
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32万元
| 课题负责人 |
| 09YZ104 | 免疫活性肽段ergotope对类风湿关节炎的免疫干预研究 | 上海市教委基金 |
2009-01~2011-12
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8万元
| 课题负责人 |
| 2007126 | 类风湿关节炎中骨桥蛋白调控IL-17表达的机制及发病学意义 | 上海市卫生局,局级课题 |
2008-01~2010-12
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3万元
| 课题负责人 |
| 07ZR14066 | 骨桥蛋白调控IL-17表达在类风湿关节炎中发病机制的研究 | 上海市科委,自然基金 |
2007-11~2009-11
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10万元
| 课题负责人 |
- 学术论文
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Jinglue Song, Hongli Liu, Qi Zhu, Yutong Miao, Feiyan Wang, Fan Yang, Wenjing Cheng, Yebin Xi, Xiaoyin Niu, Dongyi He,
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T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-??B
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BioMed Research International
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2018
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4901591:1
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Xiao-Xiao Hou,, Amir M. Hossini, Tingting Hu, Lanqi Wang, Zhanyan Pan, Lingyi Lu, Ke Cao, Ying Ma, Christos C. Zouboulis, Longqing Xia, Qiang Ju.
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Aryl Hydrocarbon Receptor Modulates the Expression of TNF-α and IL-8 in Human Sebocytes via the MyD88-p65NF-κB/p38MAPK Signaling Pathways.
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J Innate Immun.
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2018
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1-13
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Cennan Yin1,Chenyun Wu, Xinyue Du, Yan Fang, Juebiao Pu, Jianhua Wu,Lili Tang, Wei Zhao, Yongqiang Weng, Xiaokui Guo,,Zhaojun Wang
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PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS
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.Frontiers in immunology
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2018
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9:2609.
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Qing Zhao, Wenjing Cheng, Yebin Xi, Zheyi Cao, Yunzhi Xu, Ting Wu, Chengzhen Li, Xiaoyin Niu,
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IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis.
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Molecular Immunology
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2018
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93:20–30
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Niu Xiaoyin,Deng Shaohua,Li Shan,Xi Yebin,Li Chengzhen,Wang Li,He Dongyi,Wang Zhaojun,
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Effect of Ergotope Peptides on Collagen-Induced Arthritis by Downregulation of Inflammatory and Th1/Th17 Responses and Induction of Regulatory T cells.
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Mol Immunol
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2016
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22：608~620
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Wu Ting,
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miRNAs Participate in MS Pathological Processes and Its Therapeutic Response
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Mediators of Inflammation
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2016
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2016
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Shicheng Guo ,Qi Zhu,Ting Jiang,Rongsheng Wang,Yi Shen,Xiao Zhu,Yan Wang,Fengmin Bai,Qin Ding,Xiaodong Zhou,,Dong Yi He.
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Genome-wide DNA methylation patterns in CD4+ T cells from Chinese Han patients with rheumatoid arthritis.
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Modern Rheumatology
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2016
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1：1~7
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Fang Y, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G,
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SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development.
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Acta Trop
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2015
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149:49-58
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Li C, Xi Y, Li S, Zhao Q, Cheng W, Wang Z, Zhong J, Niu X,
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Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation
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Molecular Immunology
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2015
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pii: S0161-5890(15)30021-3. doi: 10.1016/j.molimm
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Xu Yunzhi,Zhu Qi,Song Jinglve,Liu Hongli,Miao Yutong,Yang Fan,Wang Feiyan,Cheng Wenjing,Xi Yebin,Niu iaoyin,He Dongyi,
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Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid
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Mediators Inflamm
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2015
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2015:356040-356040
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Xu YZ,
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Mast Cell and Autoimmune Diseases
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Mediators of Inflammation
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2015
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Volume 2015, Article ID 246126
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Cheng WJ, Zhao Q, Xi YB, Li CZ, Xu YZ, Wang L, Niu XY,Wang ZJ,
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IFN-β inhibits infiltrated T cells accumulation in the central nervous system by reducing the expression of chemokines in experimental autoimmune encephalomyelitis
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Molecular Immunology.
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2015
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64:152-162.
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Cheng WJ,
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Chemokines and Chemokine Receptors in Multiple Sclerosis. Mediators of Inflammation
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Mediators of Inflammation
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2014
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2014:659206-14
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Zhao Q,
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Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases
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BioMed Research International
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2014
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Volume 2014, Article ID 587376
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Niu XY,
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Clinical Biomarkers and Pathogenic-Related Cytokines in Rheumatoid Arthritis
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Journal of Immunology Research
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2014
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Volume 2014, Article ID 698192
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Li S, Niu XY, Xi YB, Deng SH, Li CZ, Zhao Q,
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T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis.
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Clinical and Developmental Immunology
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2013
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2013:967301-9
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Niu XY,
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IL-21 and Related Diseases
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Clinical and J Clin Cell Immunol
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2013
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2013:1-008
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Chen M,, Deng S, Liu X, Hutton GJ, Hong J.
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IFN-? induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis.
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J Neuroimmunol.
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2012
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242:39-46
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Chang SH, Reynolds JM, Pappu BP,, Martinez GJ, Dong C
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Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E.
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Immunity
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2011
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35:1–11
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Niu XY, He DY, Deng SH, Li WY, Xi YB, Xie CY, Jiang T, Zhang J, Dong C,
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Regulatory immune responses induced by IL-1 receptor antagonist inrheumatoid arthritis.
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Molecular Immunology
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2011
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49:290-296
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Xiaoyin Niu, Dongyi He, Xin Zhang, Ningli Li, Jingwu Z Zhang, Chen Dong,
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IL-21 regulates Th17 cells in rheumatoid arthritis.
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Human Immunology
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2010
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71(4):334-341
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Deng SH, Xi YB, Wang H, Hao J, Niu XY, Li WY, Yue T,
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Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis.
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Cell Immunol.
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2010
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265(2):105-10
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, Zhang X, Li RS, Niu XY, zheng YX, He DY, Xu R, Zhang JW.
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Role of Osteopontin in Synovial Th17 Differentiation in Rheumatoid Arthritis.
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Arthritis & Rheumatism
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2010
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62(10):2900–2908
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Immunotherapy of Rheumatoid Arthritis：targeting on inflammatory cytokines and autoreactive T cells.
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Archivum Immunologiae et Therapiae Experimentalis
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2010
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58:27-36
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Yang H, Qiu LH, Di W, Zhao AM,, Hu K, Lin QD.
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Proportional Change of CD4+CD25+ Regulatory T Cells after lymphocyte therapy in Unexplained Recurrent Spontaneous Abortion Patients.
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Fertility and Sterility
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2009
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92(1):301-5
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Chen MY,, Nie H, Zhang X, Niu XY, Zang Y, Skinner SM, Zhang JW, Killian JM, Hong J.
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Regulatory effect of Interferon-Beta on Production of IL-17 and Osteopontin in CD4+ T Cells in Multiple Sclerosis.
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European Journal of Immunology.
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2009
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39(9):2525-2536
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, Hao J, Xi YB, Wang W, Wang ZJ, Li NL & Li WY.
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The Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Arthritis is Associated with CD4+CD25+ T Regulatory Cells.
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Scandinavian Journal of Immunology.
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2008
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68:572–578
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Yan B, Ye S,, Kuang M, Shen N, Chen SL.
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Dysfunctional CD4+CD25+regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α producing antigen-presenting cells.
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Arthritis & Rheumatism
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2008
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58(3):801-812
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Yang H, Qiu LH,, Ye Z, Lv CJ, Lin QD.
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Proportional Change of CD4+CD25+ Regulatory T Cells in Decidua and Peripheral Blood in Unexplained Recurrent Spontaneous Abortion Patients.
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Fertility and Sterility
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2008
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89(3):656-661
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Han YP,
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A Method of Analyzing the Structures of Misfolding Proteins like Prion Protein.
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Proceeding of 2nd International Conference on Bioinformatics and Biomedical Engineering (iCBBE2008)
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2008
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1:253-255
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, Li NL, Zang YQ, Zhang DQ, He DY, Feng GZ, Ni LQ, Xu R, Wang L, Shen BH, Zhang JW.
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Vaccination with selected synovial T cells in Rheumatoid arthritis.
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Arthritis & Rheumatism
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2007
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56(2)453-463
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