• 基本信息
    导师姓名: 陈广洁 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: 上海市重庆南路280号5号楼906室 邮箱:chenguangjie@sjtu.edu.cn, guangjie_chen@163.com 办公室电话:021-63846590-776364
    邮箱地址: chenguangjie@sjtu.edu.cn 邮编: 200025
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    没有社会任职信息
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81771731关节滑膜肥大细胞的区域免疫特性及其介导的Th17活化和相互作用在类风湿关节炎发病中的研究国家自然科学基金,面上项目 2018-01~2021-10 55万元  课题负责人
    81373208IFN-β调控OPN/Th17炎性通路在多发性硬化中的机理研究国家自然科学基金 2014-01~2017-12 70万元  课题负责人
    2011177β-干扰素对多发性硬化的免疫调节机制研究卫生局科技发展基金 2012-01~2012-12 3万元  课题负责人
    12ZZ103IFN-β恢复多发性硬化IFN-β在实验性自身免疫性脑脊髓炎中的免疫调节机制研究上海市教委科研创新(重点) 2012-01~2014-12 16万元  课题负责人
    11JC1411602IFN-β恢复多发性硬化Treg/Th17平衡作用机制的研究上海市科委基础研究重点项目 2012-01~2014-12 15万元  课题负责人
    30972743免疫活性肽段ergotype在类风湿关节炎中的免疫调节作用研究国家自然基金,面上项目 2010-01~2012-12 32万元  课题负责人
    09YZ104免疫活性肽段ergotope对类风湿关节炎的免疫干预研究上海市教委基金 2009-01~2011-12 8万元  课题负责人
    2007126类风湿关节炎中骨桥蛋白调控IL-17表达的机制及发病学意义上海市卫生局,局级课题 2008-01~2010-12 3万元  课题负责人
    07ZR14066骨桥蛋白调控IL-17表达在类风湿关节炎中发病机制的研究上海市科委,自然基金 2007-11~2009-11 10万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Niu Xiaoyin,Deng Shaohua,Li Shan,Xi Yebin,Li Chengzhen,Wang Li,He Dongyi,Wang Zhaojun,  Effect of Ergotope Peptides on Collagen-Induced Arthritis by Downregulation of Inflammatory and Th1/Th17 Responses and Induction of Regulatory T cells.  Mol Immunol  2016  22:608~620 
    Wu Ting,  miRNAs Participate in MS Pathological Processes and Its Therapeutic Response  Mediators of Inflammation  2016  2016 
    Shicheng Guo ,Qi Zhu,Ting Jiang,Rongsheng Wang,Yi Shen,Xiao Zhu,Yan Wang,Fengmin Bai,Qin Ding,Xiaodong Zhou,,Dong Yi He.  Genome-wide DNA methylation patterns in CD4+ T cells from Chinese Han patients with rheumatoid arthritis.  Modern Rheumatology  2016  1:1~7 
    Fang Y, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G,  SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development.  Acta Trop  2015  149:49-58 
    Li C, Xi Y, Li S, Zhao Q, Cheng W, Wang Z, Zhong J, Niu X,  Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation  Molecular Immunology  2015  pii: S0161-5890(15)30021-3. doi: 10.1016/j.molimm 
    Xu Yunzhi,Zhu Qi,Song Jinglve,Liu Hongli,Miao Yutong,Yang Fan,Wang Feiyan,Cheng Wenjing,Xi Yebin,Niu iaoyin,He Dongyi,  Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid  Mediators Inflamm  2015  2015:356040-356040 
    Xu YZ,  Mast Cell and Autoimmune Diseases  Mediators of Inflammation  2015  Volume 2015, Article ID 246126 
    Cheng WJ, Zhao Q, Xi YB, Li CZ, Xu YZ, Wang L, Niu XY,Wang ZJ,  IFN-β inhibits infiltrated T cells accumulation in the central nervous system by reducing the expression of chemokines in experimental autoimmune encephalomyelitis  Molecular Immunology.   2015  64:152-162. 
    Cheng WJ,  Chemokines and Chemokine Receptors in Multiple Sclerosis. Mediators of Inflammation  Mediators of Inflammation  2014  2014:659206-14 
    Zhao Q,  Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases  BioMed Research International  2014  Volume 2014, Article ID 587376 
    Niu XY,  Clinical Biomarkers and Pathogenic-Related Cytokines in Rheumatoid Arthritis  Journal of Immunology Research  2014  Volume 2014, Article ID 698192 
    Li S, Niu XY, Xi YB, Deng SH, Li CZ, Zhao Q,  T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis.   Clinical and Developmental Immunology  2013  2013:967301-9 
    Niu XY,  IL-21 and Related Diseases  Clinical and J Clin Cell Immunol  2013  2013:1-008 
    Chen M,, Deng S, Liu X, Hutton GJ, Hong J.  IFN-? induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis.   J Neuroimmunol.  2012  242:39-46 
    Chang SH, Reynolds JM, Pappu BP,, Martinez GJ, Dong C  Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E.  Immunity  2011  35:1–11 
    Niu XY, He DY, Deng SH, Li WY, Xi YB, Xie CY, Jiang T, Zhang J, Dong C,  Regulatory immune responses induced by IL-1 receptor antagonist inrheumatoid arthritis.  Molecular Immunology  2011  49:290-296 
    Xiaoyin Niu, Dongyi He, Xin Zhang, Ningli Li, Jingwu Z Zhang, Chen Dong,  IL-21 regulates Th17 cells in rheumatoid arthritis.  Human Immunology  2010  71(4):334-341 
    Deng SH, Xi YB, Wang H, Hao J, Niu XY, Li WY, Yue T,  Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis.   Cell Immunol.  2010  265(2):105-10 
    , Zhang X, Li RS, Niu XY, zheng YX, He DY, Xu R, Zhang JW.  Role of Osteopontin in Synovial Th17 Differentiation in Rheumatoid Arthritis.   Arthritis & Rheumatism  2010  62(10):2900–2908 
      Immunotherapy of Rheumatoid Arthritis:targeting on inflammatory cytokines and autoreactive T cells.   Archivum Immunologiae et Therapiae Experimentalis  2010  58:27-36 
    Yang H, Qiu LH, Di W, Zhao AM,, Hu K, Lin QD.   Proportional Change of CD4+CD25+ Regulatory T Cells after lymphocyte therapy in Unexplained Recurrent Spontaneous Abortion Patients.  Fertility and Sterility  2009  92(1):301-5 
    Chen MY,, Nie H, Zhang X, Niu XY, Zang Y, Skinner SM, Zhang JW, Killian JM, Hong J.   Regulatory effect of Interferon-Beta on Production of IL-17 and Osteopontin in CD4+ T Cells in Multiple Sclerosis.   European Journal of Immunology.  2009  39(9):2525-2536 
    , Hao J, Xi YB, Wang W, Wang ZJ, Li NL & Li WY.   The Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Arthritis is Associated with CD4+CD25+ T Regulatory Cells.  Scandinavian Journal of Immunology.  2008  68:572–578 
    Yan B, Ye S,, Kuang M, Shen N, Chen SL.  Dysfunctional CD4+CD25+regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α producing antigen-presenting cells.  Arthritis & Rheumatism  2008  58(3):801-812 
    Yang H, Qiu LH,, Ye Z, Lv CJ, Lin QD.  Proportional Change of CD4+CD25+ Regulatory T Cells in Decidua and Peripheral Blood in Unexplained Recurrent Spontaneous Abortion Patients.  Fertility and Sterility  2008  89(3):656-661 
    Han YP,  A Method of Analyzing the Structures of Misfolding Proteins like Prion Protein.  Proceeding of 2nd International Conference on Bioinformatics and Biomedical Engineering (iCBBE2008)  2008  1:253-255 
    , Li NL, Zang YQ, Zhang DQ, He DY, Feng GZ, Ni LQ, Xu R, Wang L, Shen BH, Zhang JW.   Vaccination with selected synovial T cells in Rheumatoid arthritis.   Arthritis & Rheumatism  2007  56(2)453-463