• 基本信息
    导师姓名： 易静 学科代码： 100100
    性别： 女 学科名称： 基础医学
    培养单位： 基础医学院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： 专业领域代码：
    邮编： 邮箱地址： yijing@shsmu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    细胞生物学学报编委
    中国细胞生物学会继续教育工作委员会主任
    中华医学会医学细胞生物学分会常务理事
    中国细胞生物学会资深理事
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    31471263基于单个活细胞实时影像技术对B23蛋白感应核仁应激发生定位和功能改变机制的研究国家自然科学基金，面上项目 2015-01~2018-12 80万元  课题负责人
    2013CB910902赖氨酸翻译后修饰及对蛋白质功能的调控作用 课题二：肿瘤发生发展过程中细胞核蛋白的赖氨酸修饰信号调控网络科技部重大科学研究计划项目子课题 2013-01~2017-12 246万元  子课题负责人
    31230037SENP3应答细胞氧化应激调控转录因子修饰的机制及其在胃炎相关胃癌中的作用国家自然科学基金重点项目 2013-01~2017-12 285万元  课题负责人
    11JC1406900SENP3在氧化应激诱导上皮间质转化中的作用及其对胃炎相关胃癌的影响市科委基础研究重点项目（连续支持） 2011-12~-2014-12 30万元  课题负责人
    91013012以紫草素衍生物/低氧诱导因子-1为模型，探讨抗癌醌类化合物结构与靶向作用特异性和活性氧效应普遍性的关系国家自然科学基金重大研究计划培育项目 2011-01~-2013-12 50万元  课题负责人
    0810410704000利用以脂质体模拟线粒体的无细胞系统进行靶向Bcl-2蛋白的抗癌化合物筛选和机制研究市科委国际合作项目 2010-04~2012-03 15万元  课题负责人
    C0701核仁蛋白质SENP3应答细胞氧化应激信号的机制国家自然基金，面上项目 2010-01~2012-12 35万元  课题负责人
    08JC1413800植物小分子化合物靶向抑制HIF-1治疗非雄激素依赖的前列腺癌的机制和应用研究市科委基础研究重点项目 2008-10~2010-09 30万元  课题负责人
    30570965活性氧通过低氧诱导因子-1的化学修饰影响肿瘤细胞耐药性的机制国家自然基金委,面上项目 2006-01~2008-12 28万元  课题负责人
    08JC1413800植物小分子化合物靶向抑制HIF-1治疗非雄激素依赖的前列腺癌的机制和应用研究上海市科委，基础重点项目 ~2010-09 30万元   
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Wang M, Sang J, Ren Y1 Liu K, Liu X, Zhang J, Wang H, Wang J, Orian A4, Yang J, Yi J   SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.   Protein Cell.  2016  7(1):63–77  
    Yang K, Wang M, Zhao Y, Sun X, Yang Y, Li X, Zhou A, Chu H, Zhou H, Xu J, Wu M, Yang J,  A redox mechanism underlying nucleolar stress sensing by nucleophosmin.   Nat Commun.  2016  Nov 25;7:13599. doi: 10.1038/ncomms13599. 
    Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J,  SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer.   Oncogene.  2016  35（45）：5826–5838 
    Zhao Y, Hu Q, Cheng F, Su N, Wang A, Zou Y, Hu H, Chen X, Zhou HM5, Huang X, Yang K, Zhu Q, Wang X,, Zhu L, Qian X, Chen L, Tang Y, Loscalzo J, Yang Y.   SoNar, a highly responsive NAD(+)/NADH sensor, allows high-throughput metabolic screening of anti-tumor agents.   Cell Metab.   2015  21(5):777-789 
    Ren YH, Liu KJ, Wang M, Yu YN, Yang K, Chen Q, Yu B, Wang W, Li QW, Wang J, Hou ZY, Fang JY, Yeh ET, Yang J,  De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells.   Oncotarget  2014  5(16):7093-7104 
    Wang Y, Yang J,  Redox sensing by proteins: oxidative modifications on cysteines and the consequent events.   Antioxid Redox Signal.  2012  16 (7)：649-657 
    Wang Y, Yang J, Yang K, Cang H, Huang XZ, Li H, Yi J  The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress.   Acta Pharmacol Sin.  2012  33(7):953-963 
    Sang J, Yang K, Sun Y, Han Y, Cang H, Chen Y, Shi G, Wang K, Zhou J, Wang X,  SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner.   Biochem J.  2011  435(2):489-498. 
    Han Y, Huang C, Xiang B, Sun Y, Yeh ET, Chen Y, Hu Q, Wang J, Gao F,  SENP3-mediated de-conjugation of SUMO2/3 from PML is correlated with accelerated cell proliferation under mild oxidative stress.  J Biol Chem  2010  285(17):12906-15 
    Yan S, Sun X, Xiang B, Cang C, Kang X, Chen Y, Li H, Shi G, Yeh ETH, Wang B, Wang X Yi J,  Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90.  The EMBO Journal.  2010  29(22):3773-3786 
    Wang R, Zou Y, Yuan Z, Wang Y, Chen Y, Mao Y, Zhu Z, Li H, Tang X, Lu J,,   Autografts and xenografts of the skin fibroblasts delivering BMP-2 effectively promote orthotopic and ectopic osteogenesis.  The Anatomical Record,  2009  292 (6):778-786 
    Zuo Y, Xiang B, Yang J, Sun X, Wang Y, Cang H,  Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1  Cell Research  2009  19(4):449-457 
    Huang C, Han Y, Wang Y, Yan S, Sun XX, Yeh ET, Chen Y, Cang H, Li H, Cheng J, Tang XM,  SUMO-specific protease 3 is responsible for HIF-1 transactivation under mild oxidative stress via P300 de-SUMOylation.  EMBO J  2009  28(18):2748-2762 
    Wang J.,  Cancer cell killing via ROS: To increase or decrease, that is a question   Cancer Biol Ther.  2008  7(12):1875-1884 
    Cai J, Niu X, Chen Y, Hu Q, Shi G, Wu H, Wang J,  Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis  Neoplasia  2008  10(1):41-51 
    Huang XZ, Wang J, Huang C, Chen Y, Shi G, Hu Q Yi J.  Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1.  Cancer Biol Ther.  2008  7(3):468-475 
    Wang J, Li L, Cang H, Shi G,  NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells.  Leuk Res.  2008  32(3): 429-436 
    Li L., Wang J., Ye RD, Shi G. Jin H., Tang X.,Yi J.   PML/RARa fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells:   Journal of Cellular Physiology.  2008  217(2):486-493 
    Wang YM. Huang XZ. Cang H. Gao F. Ozaki T. Yamamoto T. Yi J  The endogenous reactive oxygen species promote NF-κB activation by targeting on activation of NF-κB-inducing kinase in oral squamous carcinoma cells.  Free Radic Res.  2007  41(9):963-71 
    Jing Y, Yang J, Wang Y, Li H, Chen Y, Hu Q, Shi G, Tang X,  Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin  Free Radic Biol Med.  2006  40(12):2183-97 
    , J.; Yang, J.; He, R.; Gao, F.; Sang, H.R.; Tang, X.M.; Ye, R.D  Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling  Cancer Research  2004  64(1):108-116 
    Yang J, Li H, Chen YY, Wang XJ, Shi GY, Hu QS, Kang XL, Lu Y, Tang XM, Guo QS,  Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis   Free Radical Biology and Medicine  2004  37(12):2027-2041 
      The inherent cellular level of reactive oxygen species: One of the mechanisms determing apoptotic susceptibility of leukemic cells to arsenic trioxide  Apoptosis  2002  7(3): 209-215 
    , Wang ZW, Cang H, Chen YY, Zhao R, Yu BM, Tang XM  p16 gene methylation in colorectal cancers is associated with Dukes’staging  World Journal of Gastrienterology  2001  7(5):722-725 
    , Yu DR, Chen Y, Xiong W, Li X, Shen J, Tang XM  p16 overexpression in pituitary adenoma studied by immunohistochemistry and in situ hybridization  Chin Med J  2000  113 (2):162-166 
      The convergent point of the endocytotic and autophgic pathways   Cell Research  1999  9(4):243-253 
    Chevalier J,, Michel O, Tang XM  Biotin and digoxigenin as labels for light and electron microscopy in situ hybridization probes: Where do we stand?   Journal of Histochemistry and Cytochemistry  1997  45 (4):481-491 
    , Michel O, Sassy-Prigent C, Chevalier J  Electron Microscopic Location of mRNA in the rat kidney: improved post-embedding in situ hybridization  Journal of Histochemistry and Cytochemistry  1995  43(8):801-809 
    , Tang XM  Functional Implication of Autophagy in Steroid-Secreting Cells of the Rat  The Anatomical Record  1995  242（1）:137-146