- 基本信息
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导师姓名：
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张雪艳
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学科代码：
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100201
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性别：
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女
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学科名称：
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内科学
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培养单位：
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附属胸科医院
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三级学科
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呼吸系病
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导师类型：
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硕士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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zhangxueyan570@163.com
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专业领域代码：
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105101
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邮编：
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200030
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邮箱地址：
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zhangxueyan570@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 2018YNJCM05 | 肺干细胞样癌细胞介导微环境中癌相关成纤维细胞表达Wnt5a促进自我更新的机制研究 | 上海市胸科医院院内培育项目 |
2019-01~2020-12
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20万元
| 课题负责人 |
| 18441904700 | 治疗良性气道狭窄的冷冻扩张一体化球囊研发及验证 | 上海市科学技术委员会 |
2018-04~2021-06
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50万元
| 课题负责人 |
| 81502450 | OCT4及Sox2抗原特异性CTL靶向杀灭耐药性肺癌干细胞的实验研究 | 国家自然科学基金 |
2016-01~2018-12
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18万元
| 课题负责人 |
| 13ZR1438600 | 靶向肺腺癌干细胞Wnt信号通路的抗癌机制研究 | 上海市科委 |
2013-07~2016-06
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10万元
| 课题负责人 |
- 学术论文
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Li C, Guo J, Zhao L, Hu F, Nie W, Wang H,Zheng X, Shen Y, Gu P, Zhang Y, Han B,
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Upfront whole brain radiotherapy for multiple brain metastases in patients with EGFR-mutant lung adenocarcinoma
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Cancer management and research
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2019
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11:3433-3443
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, Hu F, Li C, Zheng X, Zhang B, Wang H, Tao G, Xu J, Zhang Y, Han B
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OCT4&SOX2 specific cytotoxic T lymphocytes plus PD-1 inhibitor presented with synergistic effect on killing lung cancer stem-like cells in vitro and treating drug-resistant lung cancer mice in vivo
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Journal of Cellular Physiology
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2019
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234(5):6758- 6768
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Hu F, Xu J, Zhang B, Li C, Nie W, Gu P, Hu P, Wang H, Zhang Y, Shen Y, Wang S,
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Efficacy of local consolidative therapy for oligometastatic lung adenocarcinoma patients harboring epidermal growth factor receptor mutations
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Clinical lung cancer
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2019
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20: e81-e90
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Hu F, Zhang B, Li C, Xu J, Wang H, Gu P, Zheng X, Nie W, Zheng X, Zhang H, Hu P,
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Prognosis of EGFR- mutant advanced lung adenocarcinoma patients with different intrathoracic metastatic patterns
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Journal of Cancer
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2019
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10(5): 1254-1262
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Qian J,, Zhang B, Gu P, Wang L, Han B
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Hepatotoxicity in Advanced Lung Adenocarcinoma: A Retrospective Study of 2108 Cases
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Journal of Cancer
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2018
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9(9): 1607-1613
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Hu F, Mao X, Zhang Y, Zheng X, Gu P, Wang H,
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Reliability of using circulating tumor cells for detecting epidermal growth factor receptor mutation status in advanced non-small-cell lung cancer patients: a meta-analysis and systematic review
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Onco Targets Ther
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2018
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11: 1373-1384
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, Zhang Y, Xu J, Wang H, Zheng X, Lou Y, Han B
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Antigen presentation of the Oct4 and Sox2 peptides by CD154- activated B lymphocytes enhances the killing effect of cytotoxic T lymphocytes on tumor stem-like cells derived from cisplatin-resisitant lung cancer cells
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Journal of Cancer
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2018
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9(2):367-374
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, Zheng X, Lou Y, Wang H, Xu J, Zhang Y, Han B
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β-catenin inhibitors suppress cells proliferation and promote cells apoptosis in PC9 lung cancer stem cells.
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Int J Clin Exp Pathol
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2017
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10(12): 11968-11978
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, Lou Y, Wang H, Zheng X, Dong Q, Sun J, Han B
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Wnt signaling regulates the stemness of lung cancer stem cells and its inhibitors exert anticancer effect on lung cancer SPC-A1 cells
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Med Oncol
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2015
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32(4):95
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, Lou Y, Zheng X, Wang H, Sun J, Dong Q, Han B
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Wnt blockers inhibit the proliferation of lung cancer stem cells
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Drug Des Devel Ther
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2015
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9:2399-407
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邵建伟,陆一鸣,韩宝惠,董强刚,郑必强,
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正常肺及肺腺癌组织中细支气管肺泡干细胞相关指标的表达
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中国医药
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2014
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9(1): 27-31
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,王慧敏,楼煜清,金波,韩宝惠
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肺腺癌组织中B细胞特异性莫洛氏鼠白血病病毒插入位点基因1表达与患者临床指标及预后的相关性
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中国医药
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2014
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9(1): 32-36
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Lou Y, Li R, Zhang Y, Zhong R, Pei J, Xiong L,, Han B
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XPA gene rs1800975 single nucleotide polymorphism and lung cancer risk: a meta-analysis
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Tumour Biol
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2014
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35(7):6607-17
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, Sun J, Wang H, Lou Y, Zhang Y, Sha H, Feng J, Han B
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IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance
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Tumour Biol
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2014
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35(1):739-45
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,韩宝惠
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表皮生长因子受体-酪氨酸激酶抑制剂的耐药机制及其应对策略
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中国处方药
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2013
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(1):45-48
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,王慧敏,金波,董强刚,黄进肃,韩宝惠
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肺腺癌组织中OCT4表达与患者临床指标及预后的相关性
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中国肺癌杂志
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2013
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16(4): 197-202
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, Dong QG, Huang JS, Huang AM, Shi CL, Jin B, Sha HF, Feng JX, Geng Q, Zhou J, Xu HL, Han BH
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The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma
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J Surg Oncol
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2010
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102(7):856-62
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, Han B, Huang J, Zheng B, Geng Q, Aziz F, Dong Q
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Prognostic significance of OCT4 expression in adenocarcinoma of the lung
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Jpn J Clin Oncol
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2010
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40(10):961-6
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, 冯久贤, 沙惠芳, 黄进肃, 韩宝惠
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肺腺癌组织中IGF-IR表达与患者临床病理因素及预后的相关性
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中国肺癌杂志
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2010
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13(12):1113-1117
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, 郑必强, 韩宝惠, 黄进肃, 耿沁, 徐惠莉, 周瑾, 董强刚
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人肺腺癌干细胞的表型及其与肺腺癌患者预后的关系
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中华肿瘤杂志
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2009
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31(11):836-840
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, 黄艾弥, 白皓, 陈玉蓉, 韩宝惠
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培美曲塞单药或联合化疗治疗晚期复发性非小细胞肺癌68例分析
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中国癌症杂志
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2009
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19(2):118-121
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