• 基本信息
    导师姓名： 洪洁 学科代码： 100201
    性别： 女 学科名称： 内科学
    培养单位： 附属瑞金医院 三级学科 内分泌与代谢病
    导师类型： 博士生导师 专业领域名称： 内科学 专业学位
    联系方式： 上海交通大学医学院附属瑞金医院内分泌科，上海市内分泌代谢病研究所 专业领域代码： 105101
    邮编： 200025 邮箱地址： hongjie@medmail.com.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市医学会糖尿病分会第八届专科分会副主任委员
    《中华糖尿病杂志》编委
    《中华内分泌代谢病杂志》编委
    中华医学会糖尿病学分会第九届委员
    上海市医学会内科专科分会第九届委员会委员
    Journal of Diabetes 编辑委员会编委
    上海市医学会糖尿病分会第8届专科分会糖尿病饮食与营养治疗学组组长
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    82070863减重手术通过“肠-脑轴”重塑食欲的作用机制研究国家自然科学基金面上项目 2021-01~2024-12 55万元  课题负责人
    81870582人类肠道常驻菌Akkermansia muciniphila对白色脂肪棕色化及能量代谢的作用研究国家自然科学基金面上项目 2019-01~2022-12 57万元  课题负责人
    2018YFC1313800肠道与下丘脑在糖尿病发生发展中的作用及干预新方案研究重大慢性非传染性疾病防控研究 2018-09~2020-12 1104万元  课题负责人
    2015BAI12B14中国成人糖尿病的发病危险因素、动态监测及综合防治国家科技支撑计划 2015-04~2017-12 939万元  课题负责人
    81471060BMPs拮抗因子PRDC在米色脂肪分化及肥胖发生中作用机制研究国家自然科学基金面上项目 2015-01~2018-12 65万元  课题负责人
    14411961200利用头颅fMRI探讨肥胖患者减重手术前后食欲变化的研究上海市科委 2014-10~2017-09 30万元  课题负责人
    XBR2013073在中国青少年肥胖人群与动物模型中的有益菌筛选及其临床减重有效性初探上海市卫生和计划生育委员会 2013-11~2016-10 85万元  课题负责人
    81270931SFRP5/β-Catenin信号通路在脂肪发育及体重调节中的作用国家自然基金面上项目 2013-01~2016-12 70万元  课题负责人
    201202008分子标志物在自身免疫性疾病诊疗中的应用于推广卫生行业科研专项项目 2012-01~2014-12 164万元  子课题负责人
    10dz192082美哒灵、优哒灵临床用药评价及药物经济学研究上海市科学技术委员会 2010-08~2013-09 28万元  子课题负责人
    30971077解耦联蛋白3基因敲除改善胰岛素敏感性的机制探讨国家自然基金面上项目 2010-01~2010-12 8万元  课题负责人
    04BC42OGTT中30''和/或者60''高血糖者自然转归的前瞻性研究上海市教委青年基金 2004-07~2007-06 5万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    , Tingting Bo, Liuqing Xi, Xiaoqiang Xu, Naying He, Yafeng Zhan, Wanyu Li, Peiwen Liang, Yufei Chen, Juan Shi, Danjie Li, Fuhua Yan, Weiqiong Gu, Weiqing Wang, Ruixin Liu, Jiqiu Wang, Zheng Wang, Guang Ning  Reversal of functional brain activity related to gut microbiome and hormones after VSG surgery in patients with obesity  J Clin Endocrinol Metab  2021  5(05):297 
    Yufei Chen, Lijia Chen, Lingxia Ye, Jiabin Jin, Yingkai Sun, Ling Zhang, Shaoqian Zhao, Yifei Zhang, Weiqing Wang, Weiqing Gu,  Association of metabolic syndrome with prevalence of obstructive sleep apnea and remission after sleeve gastrectomy  frontiers in physiology  2021  12:650260 
    Sun Y, Wang R, Zhao S, Li W, Liu W, Tang L, Wang Z, Wang W, Liu R, Ning G, Wang J,  FGF9 inhibits browning program of white adipocytes and associates with human obesity  Journal of Molecular Endocrinology  2019  1;62(2):79-90 
    Liu R,, Xu X, Feng Q, Zhang D, Gu Y, Shi J, Zhao S, Liu W, Wang X, Xia H, Liu Z, Cui B, Liang P, Xi L, Jin J, Ying X, Wang X, Zhao X, Li W, Jia H, Lan Z, Li F, Wang R, Sun Y, Yang M, Shen Y, Jie Z, Li J, Chen X, Zhong H, Xie H, Zhang Y, Gu W, Deng X, Shen B, Xu X, Yang H, Xu G, Bi Y, Lai S, Wang J, Qi L, Madsen L, Wang J, Ning G, Kristiansen K, Wang W  Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention  Nat Med  2017  23(7):859-868 
    Zhao S, Liu W, Wang J, Shi J, Sun Y, Wang W, Ning G, Liu R,  Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice  J Mol Endocrinol  2017  58(1):1-14 
    Liu R, Zou Y,, Cao M, Cui B, Zhang H, Chen M, Shi J, Ning T, Zhao S, Liu W, Xiong H, Wei C, Qiu Z, Gu W, Zhang Y, Li W, Miao L, Sun Y, Yang M, Wang R, Ma Q, Xu M, Xu Y, Wang T, Chan KK, Zuo X, Chen H, Qi L, Lai S, Duan S, Song B, Bi Y, Liu S, Wang W, Ning G, Wang J  Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity  Diabetes  2017  66(4):935-947 
    Liang P, Xi L, Shi J, Li W, Zhao S, Deng Y, Wang R, Sun Y, Gu B, Yuan L, Zhang Y, Gu W, Wang W,  Prevalence of polycystic ovary syndrome in Chinese obese women of reproductive age with or without metabolic syndrome  Fertil Steril  2017  107(4):1048-1054 
    Liu W, Zhao S, Wang J, Hong J et al.   Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high‐fat diet mice  Mol Nutr Food Res  2017  61(9): doi: 10.1002 
    Li Y, Shi J, Huang X, Wang R, Gu B, Liang P, Zhao S, Sun Y, Liu W, Deng Y, Xi L, Zhao D, Song D, Cao Y, Zhang Y, Gu W,  Glycated Hemoglobin is Independently Associated with Albuminuria in Young Nondiabetic People with Obesity  Med Sci Monit  2017  29;23:2612-2618 
    Yang M, Chen M, Wang J, Xu M, Sun J, Ding L, Lv X, Ma Q, Bi Y, Liu R,, Ning G.  Bisphenol A Promotes Adiposity and Inflammation in a Nonmonotonic Dose-response Way in 5-week-old Male and Female C57BL/6J Mice Fed a Low-calorie Diet.  Endocrinology.   2016  157(6):2333-45. doi: 10.1210/en.2015-1926. Epub 2016 May 4. 
    Sun Y,, Chen M, Ke Y, Zhao S, Liu W, Ma Q, Shi J, Zou Y, Ning T, Zhang Z, Liu R, Wang J, Ning G  Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway  2. Biochem Biophys Res Commun  2015  464(2):396-400 
    Wang R,, Cao Y, Shi J, Gu W, Ning G, Zhang Y, Wang W  Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults  Eur J Endocrinol  2015  172(3):291-300 
    Zhang Y, Hu C,, Zeng J, Lai S, Lv A, Su Q, Dong Y, Zhou Z, Tang W, Zhao J, Cui L, Zou D, Wang D, Li H, Liu C, Wu G, Shen J, Zhu D, Wang W, Shen W, Ning G, Xu G  Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with type 2 diabetes and coronary artery disease  Diabetes care  2014  37(10):2804-2812 
    Wang R,, Liu R, Chen M, Xu M, Gu W, Zhang Y, Ma Q, Wang F, Shi J, Wang J, Wang W, Ning G  SFRP5 acts as a mature adipocyte marker but not as a regulator in adipogenesis  J Mol Endocrinol  2014  53(3):405-415 
    Yifei Zhang,,Jie Chi,Weiqiong Gu,Guang Ning,Weiqing Wang  Head-to-head comparison of dipeptidyl peptidase- IV inhibitors and sulfonylureas – a meta-analysis from randomized clinical trials  Diabetes Metab Res Rev  2014  30(3):241-256 
    Shi J, Li L,, Qi L, Cui B, Gu W, Zhang Y, Miao L, Wang R, Wang W, Ning G  Genetic variants determining body fat distribution and sex hormone-binding globulin among Chinese female young adults  J Diabetes  2014  6(6):514-518 
    Shi J,, Qi L, Cui B, Gu W, Zhang Y, Li L, Miao L, Wang R, Wang W, Ning G  Genetic predisposition to obesity and risk of subclinical atherosclerosis  Gene  2014  549(2):223-227 
    王睿,王计秋,刘瑞欣,陈茂培,,王卫庆,宁光  分泌型卷曲相关蛋白/β-联蛋白信号通路对脂肪形成的影响  内科理论与实践  2013  8(1):34-38 
    缪琳,,张翼飞,顾卫琼,石娟,李丽娟,王睿,陈颖超,王柏凯,高捷,李小英,王卫庆,宁光  育龄期女性血清催乳素水平与胰岛素敏感性之间的相关性研究  中华内分泌代谢杂志  2013  29(4):307-310 
    , Zhang Y, Lai S, Lv A, Su Q, Dong Y, Zhou Z, Tang W, Zhao J, Cui L, Zou D, Wang D, Li H, Liu C, Wu G, Shen J, Zhu D, Wang W, Shen W, Ning G; on behalf of the SPREAD-DIMCAD Investigators  Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease  Diabetes Care  2013  36(5):1304-1311 
    缪琳,石娟,,张翼飞,顾卫琼,李丽娟,王柏凯,王睿,张娟娟,王计秋,李小英,王卫庆 ,宁光  低浓度性激素结合球蛋白与代谢综合征的发生相关  中华内分泌代谢杂志  2013  29(6):494-497 
    , Shi J, Qi L, Cui B, Gu W, Zhang Y, Li L, Xu M, Wang L, Zhai Y, Miao L, Wang R, Bi Y, Wang W, Ning G  Genetic susceptibility, birth weight and obesity risk in young Chinese  Int J Obes  2013  37(5):673-677 
    李丽娟,石娟,,顾卫琼,张翼飞,陈颖超,缪琳,王睿,高捷,王柏凯,王卫庆,宁光  肥胖青少年血清睾酮水平与代谢综合征的关系  临床内科杂志  2012  29(7):463-466 
      肥胖症遗传学研究  中国实用内科杂志  2012  32(10):734-737 
    Yan Q, Zhang Y,, Gu W, Dai M, Shi J, Zhai Y, Wang W, Li X, Ning G  The association of serum chemerin level with risk of coronary artery disease in Chinese adults  Endocrine  2012  41(2):281-8 
    Shi J, Zhang Y, Gu W, Cui B, Xu M, Yan Q, Wang W, Ning G,  Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults  PLoS One  2012  7(11):e48777 
    石娟,张翼飞,顾卫琼,崔斌,徐敏,晏群,翟莹,王莉,李丽娟,李小英,王卫庆,宁光,  肥胖青少年患者血清肝型脂肪酸结合蛋白水平及其相关因素分析  内科理论与实践  2011  6(4):279-282 
    , Gu W, Zhang Y, Yan Q, Dai M, Shi J, Zhai Y, Wang W, Li X, Ning G  Different association of circulating levels of adipocyte and epidermal fatty acid-binding proteins with metabolic syndrome and coronary atherosclerosis in Chinese adults  Atherosclerosis  2011  217(1):194-200 
    苏玉霞,晏群,,沈春芳,顾卫琼,张翼飞,戴蒙,徐敏,迟贞旎,张豫文,李小英,宁光,王敏敏,喇端端  血清视黄醇结合蛋白4在妊娠糖尿病患者中显著升高  中华内分泌代谢杂志  2010  26(6):468-470 
    Zhang Y, Qi L, Gu W, Yan Q, Dai M, Shi J, Zhai Y, Chen Y, Liu J, Wang W, Ning G,  Relation of serum osteocalcin level to risk of coronary heart disease in Chinese adults  Am J Cardiol  2010  106(10):1461-5 
    晏群,,顾卫琼,张翼飞,张豫文,石娟,王卫庆,李小英,宁光  多囊卵巢综合征患者代谢综合征患病风险研究  中华内分泌代谢杂志  2010  26(5):351-354 
    Su YX,, Yan Q, Xu C, Gu WQ, Zhang YF, Shen CF, Chi ZN, Dai M, Xu M, Zhang YW, Liu QR, Li XY, Ning G, Wang WQ  Increased serum retinol-binding protein-4 levels in pregnant women with and without gestational diabetes mellitus  Diabetes Metab  2010  36(6 Pt 1):470-5 
    Zhang YW, Jia HY,, Ge Y, Zhang HJ, Shen CF, Ye L, Cui B, Li XY, Gu WQ, Zhang YF, Wang WQ, Ning G  Clinical and genetic analysis for four Chinese families with Prader–Willi syndrome (case report)  Endocrine  2009  36(1):37-44 
    , Zhang YW, Zhang HJ, Jia HY, Zhang Y, Ding XY, Zhou DY, Chen HP, Jiang XH, Cui B, Li XY, Ning G  The novel compound heterozygous mutations, V434del and W666X, in WFS1 gene causing the Wolfram syndrome in a Chinese family (case study)  Endocrine  2009  35(2):151-7 
    Yan Q,, Gu W, Zhang Y, Liu Q, Su Y, Zhang Y, Li X, Cui B, Ning G  Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women  Endocrine  2009  36(3):377-82 
    Yan Q, Gu WQ,, Zhang YF, Su YX, Gui MH, Zhang Y, Chi ZN, Zhang YW, Li XY, Ning G  Coronary angiographic studies of impaired glucose regulation and coronary artery disease in Chinese nondiabetic subjects  Endocrine  2009  36(3):457-63 
    Zhang Y,, Gu W, Gui M, Chen Y, Zhang Y, Chi Z, Wang W, Li X, Ning G  Impact of the metabolic syndrome and its individual components on risk and severity of coronary heart disease  Endocrine  2009  36(2):233-8 
    , Gui MH, Gu WQ, Zhang YF, Xu M, Chi ZN, Zhang Y, Li XY, Wang WQ, Ning G  Differences in insulin resistance and pancreatic B-cell function in obese subjects with isolated impaired glucose tolerance and isolated impaired fasting glucose  Diabet Med  2008  25(1):73-9 
    , Zhang YF, Gu WQ, Zhang YW, Su YX, Chi ZN, Wang WQ, Li XY, Ning G  Insulin sensitivity and first-phase insulin secretion in obese Chinese with hyperglycemia in 30 and/or 60 min during glucose tolerance tests  Endocrine  2008  34(1-3):75-80 
    Liu Q, Gu W, Cui B,, Zhang Y, Chi Z, Su Y, Ning G  The association of TAAAAn repeat polymorphism in sex hormone-binding protein gene with polycystic ovary syndrome in Chinese population  Endocrine  2008  34(1-3):62-7 
    Liu Q,, Cui B, Zhang Y, Gu W, Chi Z, Su Y, Ning G  Androgen receptor gene CAG(n) trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome  Endocrine  2008  33(2):165-70 
    Gui MH,, Lü AK, Chen Y, Shen WF, Li XY, Ning G  High sensitive C-reactive protein, adiponectin, and urine albumin excretion rate in Chinese coronary artery disease patients with different glucose tolerance status  Chin Med J  2008  121(24):2509-16