- 基本信息
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导师姓名：
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孙赟
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学科代码：
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100211
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性别：
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女
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学科名称：
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妇产科学
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培养单位：
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附属仁济医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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妇产科学 专业学位
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联系方式：
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上海市浦东新区灵山路845号仁济医院生殖医学中心
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专业领域代码：
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105115
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邮编：
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200135
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邮箱地址：
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syun163@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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妇幼健康研究会生殖内分泌学专业委员会副主委
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国家辅助生殖技术质量管理专家组
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上海市人类辅助生殖技术质控中心主任
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中华医学会生殖医学分会委员
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中国医药教育协会生殖内分泌专业委员会副主委
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上海市医师协会生殖医学医师分会副会长
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上海市医学会生殖医学分会主任委员
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中国女医师协会生殖医学专业委员会副主委
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Aspire Research Committee委员
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- 科研项目
| 82320108009 | PDHA1通过线粒体-细胞核双向定位调控子宫内膜蜕 膜化的机制研究 | 国家自然科学基金重点国合项目 |
2024-01~2028-12
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210万元
| 课题负责人 |
| 2023YFC2700022 | 开发女性生殖健康管理智能化系统，建立防治一体化生殖健康大数据 | 科技部重点研发计划 |
2023-12~2026-11
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1700万元
| 课题负责人 |
| 82130046 | 线粒体未折叠蛋白反应UPRmt在子宫内膜蜕膜化及早期妊娠失败中的作用机制 | 国家自然科学基金重点项目 |
2022-01~2026-12
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291万元
| 课题负责人 |
| RJPY-DZX-003 | 比较基于胚胎植入前遗传学筛查技术与单独形态学胚胎选择在男性无精子症患者中的活产率 | 上海交通大学医学院附属仁济医院临床科研创新培育基金计划 |
2021-12~2024-11
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100万元
| 课题负责人 |
| SHDC2020CR1046B | 口服强的松对反复种植失败疗效及母婴安全性的评价：一项随机、双盲、安慰剂对照临床研究 | 促进市级医院临床技能与临床创新能力三年行动计划-重大疾病多中心临床研究项目 |
2020-10~2022-09
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715万元
| 课题负责人 |
| 2019YFA0802604 | 发育与代谢异常获得性性状的临床预警和干预 | 科技部重点研发计划 |
2019-12~2024-11
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100万元
| 课题参与人 |
| SSMU-ZLCX20180401 | 协同创新团队 | 上海交通大学医学院高水平创新团队激励计划 |
2019-01~2023-12
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40万元
| 课题负责人 |
| / | 上海市领军人才计划 | 上海市领军人才计划 |
2019-01~2023-12
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80万元
| 课题负责人 |
| 18140902400 | 薄型子宫内膜大鼠模型建立及脂肪间充质干细胞治疗研究 | 上海市科技创新行动计划 |
2018-05~2021-04
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40万元
| 课题负责人 |
| 2017BR015 | 子宫内膜容受性基础与临床研究 | 上海市卫生计生系统百人计划 |
2018-01~2020-12
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45万元
| 课题负责人 |
| 81771648 | 环状RNA- hsa_circRNA_101280对子宫内膜容受性的作用机制 | 国家自然科学基金面上项目 |
2018-01~2021-12
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56万元
| 课题负责人 |
| 2017YPC1001403 | 子宫内膜-蜕膜转化异常与复发流产 | 科技部重点研发计划子课题 |
2017-01~2020-12
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345万元
| 子课题负责人 |
| 16CR1022A | 辅助生殖技术对母婴健康的影响：IVF出生队列研究和多中心、前瞻性、随机临床试验 | 申康临床技能与临床创新三年行动计划 |
2016-12~2019-06
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200万元
| 课题负责人 |
| 20161413 | 不孕不育与辅助生殖技术临床研究 | 上海交通大学医学院 |
2016-07~2019-06
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100万元
| 课题负责人 |
| 81571499 | 长链非编码RNA-TUNAR和LINC01502在子宫内膜容受性建立中的作用及其机制 | 国家自然科学基金面上项目 |
2016-01~2019-12
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60万元
| 课题负责人 |
| 201402004 | 人类辅助生殖技术质控体系建立的相关研究 | 卫生部卫生行业科研专项子课题 |
2014-06~2017-06
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32万元
| 子课题负责人 |
| 2014CB943300 | 环境内分泌干扰物对女性生殖功能的影响及机制 | 国家973子课题 |
2014-01~2019-12
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38.91万元
| 课题参与人 |
| 81370762 | 在体外受精中uNK细胞对胚胎种植的调控机制 | 国家自然科学基金面上项目 |
2014-01~2014-12
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16万元
| 课题负责人 |
| 12JC1405800 | ERBB3在PCOS卵子和卵泡发育中的作用及调控机制研究 | 上海市科委基础研究重点项目 |
2013-01~2015-12
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60万元
| 课题负责人 |
- 学术论文
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Hu S#, Sun Z#, Li B#, Zhao H, Wang Y, Yao G, Li X, Bian X, Li TC, Vankelecom H,
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iTRAQ-based Proteomic Analysis Unveils ACSL4 as a Novel Potential Regulator of Human Endometrial Receptivity
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Endocrinology
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2023
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2023 Jan 9;164(3):bqad012
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, Cui L#, Lu Y#, Tan J#, Dong X#, Ni T#, Yan J, Guan Y, Hao G, Liu JY, Zhang B, Wei D, Hong Y, He Y, Qi J, Xu B, Lu J, Zhang Q, Zhao S, Ji X, Du X, Zhang J, Liu J, Wang J, Huang Y, Huang D, Du Y, Vankelecom H, Zhang H, Chen ZJ*
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Prednisone vs Placebo and Live Birth in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization: A Randomized Clinical Trial
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JAMA
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2023
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2023 May 2;329(17):1460-1468
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Dong X#, Zhou M#, Li X#, Huang H*,
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Gene profiling reveals the role of inflammation, abnormal uterine muscle contraction and vascularity in recurrent implantation failure
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Front Genet
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2023
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2023 Feb 24;14:1108805
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Xu R#, Zhao H#, Qi J#, Yao G, He Y, Lu Y, Zhu Q, Wang Y, Ding Y, Zhu Z, Li X, Vankelecom H,
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Local glucose elevation activates pyroptosis via NLRP3 inflammasome in ovarian granulosa cells of overweight patients
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FASEB J
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2023
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2023 Mar;37(3):e22807
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Chen X?, Shi H?, Li C?, Zhong W?, Cui L, Zhang W, Geng L, Hu K, Fang M, Wei D, Yan J,, Wu K*, Zhao H*, Chen ZJ*
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The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study
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Sci China Life Sci
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2023
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2023 Jul;66(7):1697-1700
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Zhang C, Yao N, Lu Y, Ni J, Liu X, Zhou J, Wang W, Zhang T, He Y, Huang J, Sun K,
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Ambient air pollution on fecundity and live birth in women undergoing assisted reproductive technology in the Yangtze River Delta of China
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Environ Int
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2022
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Mar 15;162:107181
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Ding Y, Jiang Y, Zhu M, Zhu Q, He Y, Lu Y, Wang Y, Qi J, Feng Y, Huang R, Yin H, Li S, Sun Y*
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Follicular fluid lipidomic profiling reveals potential biomarkers of polycystic ovary syndrome: A pilot study
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Front Endocrinol
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2022
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2022 Sep 13;13:960274
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Wang C,
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Induction of Collagen I by CXCL10 in Ovarian Theca-Stroma Cells via the JNK Pathway
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Front Endocrinol (Lausanne)
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2022
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Apr 1;13:823740
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Zhu Q#, Yao Y#, Xu L#, Wu H, Wang W, He Y, Wang Y, Lu Y, Qi J, Ding Y, Li X, Huang J, Zhao H, Du Y, Sun K,
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Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome
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Reprod Biol Endocrinol
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2022
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Jan 3;20(1):4
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Hanting Zhao#, Shuanggang Hu#, Jia Qi#, Yuan Wang, Ying Ding, Qinling Zhu, Yaqiong He, Yao Lu, Yue Yao, Shiyao Wang, Yanzhi Du,
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Increased expression of HOXA11-AS attenuates endometrial decidualization in recurrent implantation failure patients
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Mol Ther
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2022
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Apr 6;30(4):1706-1720
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Yuan Wang#, Shuanggang Hu#*, Guangxin Yao# and Yun Sun
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Identification of HOXA10 target genes in human endometrial stromal cells by RNA-seq analysis
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Acta Biochim Biophys Sin (Shanghai)
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2021
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Mar 2;53(3):365-371
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Jia Qi#, Jiaxing Li#, Yuan Wang, Wangsheng Wang, Qinling Zhu, Yaqiong He, Yao Lu, Hasiximuke Wu, Xinyu Li, Zhenyi Zhu, Ying Ding, Rui Xu,
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Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients
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Transl Res
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2021
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Apr;230:55-67
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Jiaxing Li#, Jia Qi#, Guangxin Yao, Qinling Zhu, Xinyu Li, Rui Xu, Zhenyi Zhu, Hanting Zhao, Yuan Wang, Ying Ding and Yun Sun
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Deficiency of Sirtuin 1 impedes endometrial decidualization in recurrent implantation failure patients
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Front Cell Dev Biol
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2021
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Jan 28;9:598364
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J. Yan#, Y. Qin#, H. Zhao#,, F. Gong#, R. Li#, X. Sun#, X. Ling#, H. Li#, C. Hao, J. Tan, J. Yang, Y. Zhu, F. Liu, D. Chen, D. Wei, J. Lu, T. Ni, W. Zhou, K. Wu, Y. Gao, Y. Shi, Y. Lu, T. Zhang, W. Wu, X. Ma, H. Ma, J. Fu, J. Zhang, Q. Meng, H. Zhang, R.S. Legro, and Z.-J. Chen
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Live Birth with or without Preimplantation Genetic Testing for Aneuploidy
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N Engl J Med
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2021
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Nov 25;385(22):2047-2058
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Ying Ding, Qinling Zhu, Yaqiong He, Yao Lu, Yuan Wang, Jia Qi, Hasiximuke Wu, Rui Xu, Jiaxing Li, Xinyu Li,
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Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis: BECN1 and P4 elevation in endometriosis
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Transl Res
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2021
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Jan;227:15-29
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Lin Y#, Qi J#,
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Platelet-Rich Plasma as a Potential New Strategy in the Endometrium Treatment in Assisted Reproductive Technology
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Front Endocrinol (Lausanne)
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2021
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Oct 18;12:707584
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Lu Y#, Niu Y#, Wang Y, He Y, Ding Y, Lu X, Xu B, Lindheim SR,
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Optimal Candidates to Do Fresh Embryo Transfer in Those Using Oral Contraceptive Pretreatment in IVF Cycles
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Front Physiol
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2021
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Mar 11;12:576917
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Xinyu Li#; Shuanggang Hu#; Qinling Zhu; Guangxin Yao; Jufang Yao; Jiaxing Li; Yuan Wang; Ying Ding; Jia Qi; Rui Xu; Hanting Zhao; Zhenyi Zhu; Yanzhi Du; Kang Sun; Yun Sun
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Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model
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Metabolism
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2021
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Mar 12;154749
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Yao Lu#, Yuan Wang#, Ting Zhang, Guiquan Wang, Yaqiong He, Steven R. Lindheim, Zhangsheng Yu,
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Effect of pretreatment oral contraceptives on fresh and cumulative live birth IVF outcomes in ovulatory women
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Fertility and Sterility
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2020
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Oct;114(4):779-786
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Chuyue Zhang, Jingwen Hu, Wangsheng Wang,, Kang Sun*
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HMGB1-induced aberrant autophagy contributes to insulin resistance in granulosa cells in PCOS
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The FASEB Journal
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2020
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Jul;34(7):9563-9574
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Yuan Wang#, Shuanggang Hu#, Guangxin Yao, Qinling Zhu, Yaqiong He, Yao Lu, Jia Qi, Rui Xu, Ying Ding, Jiaxing Li, Xinyu Li,
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A novel molecule in human cyclic endometrium: lncRNA TUNAR is involved in embryo implantation
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Front. Physiol
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2020
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Nov 19;11:587448
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Yao Lu#, Yuan Wang#, Ting Zhang, Guiquan Wang, Yaqiong He, Steven R. Lindheim, Zhangsheng Yu,
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Effect of pretreatment oral contraceptives on fresh and cumulative live birth IVF outcomes in ovulatory women
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Fertility and Sterility
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2020
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2020 Jul 30;S0015-0282(20)30505-7
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Chuyue Zhang, Jingwen Hu, Wangsheng Wang,, Kang Sun*
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HMGB1-induced aberrant autophagy contributes to insulin resistance in granulosa cells in PCOS
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The FASEB Journal
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2020
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2020 May 29. doi: 10.1096/fj.202000605RR
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Yifang Wei, Shenglian Lu, Yu Hu, Li Guo, Xiaoyu Wu, Xing Liu,
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MicroRNA-135a Regulates VEGFC Expression and Promotes Luteinized Granulosa Cell Apoptosis in Polycystic Ovary Syndrome
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Reprod Sci
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2020
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Jul;27(7):1436-1442
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He Y#, Yao Lu#, Zhu Q, Wang Y, Lindheim SR, Qi J, Li X, Ding Y, Shi Y, Wei D, Chen ZJ*,
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Influence of metabolic syndrome on female fertility and in vitro fertilization outcomes in PCOS women
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Am J Obstet Gynecol
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2019
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2019 Mar 22. pii: S0002-9378(19)30489-2
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Wei Y*, Lang J, Zhang Q, Yang CR, Zhao ZA, Zhang Y, Du Y*,
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DNA methylation analysis and editing in single mammalian oocytes
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Proc Natl Acad Sci U S A
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2019
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2019 May 14;116(20):9883-9892
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Shengxian Li#, Jia Qi#, Yongzhen Tao#, Qinling Zhu, Rong Huang, Yu Liao, Jiang Yue, Wei Liu, Hanting Zhao, Huiyong Yin*,
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Elevated Levels of Arachidonic Acid Metabolites in Follicular Fluid of PCOS Patients
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Reproduction
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2019
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2019 Nov 1;REP-19-0136.R2
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Hu S#, Wang Y#, Yao G#,
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The expression changes of circular RNAs between LH?+?2 and LH?+?7 human endometrium
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Acta Biochim Biophys Sin
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2019
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2019 Nov 28. pii: gmz116
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Daimin Wei#, Jiayin Liu#,, Yuhua Shi#, Bo Zhang#, Jianqiao Liu, Jichun Tan, Xiaoyan Liang, Yunxia Cao, Ze Wang, Yingying Qin, Han Zhao, Yi Zhou, Haiqing Ren, Richard S Legro, Zijaing Chen*
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Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial
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Lancet
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2019
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2019 Feb 28. pii: S0140-6736(18)32843-5
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Li X, Zhu Q, Wang W, Qi J, He Y, Wang Y, Lu Y, Wu H, Ding Y,
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Elevated chemerin induces insulin resistance in human granulosa-lutein cells from polycystic ovary syndrome patients
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FASEB J
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2019
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2019 Jul 18:fj201802829R
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Shi Y#,, Hao C#, Zhang H#, Wei D#, Zhang Y#, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H1, Li J, Zhang 1, Chen X, Zhang S, Sun X, Legro RS, Chen ZJ
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Transfer of Fresh versus Frozen Embryos in Ovulatory Women
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N Engl J Med
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2018
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2018 Jan 11;378(2):126-136
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Hu SG#*, Liang AJ#, Yao GX#, Li XQ, Zou M, Liu JW,
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The dynamic metabolomic changes throughout mouse epididymal lumen fluid potentially contribute to sperm maturation
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Andrology
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2018
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2018 Jan;6(1):247-255
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Qi J, Wang W, Zhu Q, He Y, Lu Y, Wang Y, Li X, Chen ZJ,
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Local Cortisol Elevation Contributes to Endometrial Insulin Resistance in Polycystic Ovary Syndrome
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J Clin Endocrinol Metab
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2018
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2018 Mar 30. doi: 10.1210/jc.2017-02459
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Xuan Dang, Qinling Zhu, Yaqiong He, Yuan Wang, Xiaoxue Li, Yao Lu, Jia Qi, WU Hasiximuke,
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IL-1β up-regulates StAR and progesterone production through the ERK1/2 and p38-mediated CREB signaling pathways in human granulosa-lutein cells
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Endocrinology
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2017
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2017 Oct 1;158(10):3281-3291
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Wu J#,, Block TJ, Marinkovic M, Zhang ZL, Chen R, Yin Y, Song J, Dean DD, Lu Z, Chen XD
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Umbilical cord blood-derived non-hematopoietic stem cells retrieved and expanded on bone marrow-derived extracellular matrix display pluripotent characteristics
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Stem Cell Res Ther
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2016
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Dec 1;7(1):176
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Chen ZJ*, Shi Y,, Zhang B, Liang X, Cao Y, Yang J, Liu J, Wei D, Weng N, Tian L, Hao C, Yang D, Zhou F, Shi J, Xu Y, Li J, Yan J, Qin Y, Zhao H, Zhang H, Legro RS
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Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome
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N Engl J Med
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2016
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Aug 11;375(6):523-33
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Qinling Zhu, RujuanZuo, Yaqiong He, Yuan Wang, Zi-jiang Chen,, Kang Sun
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Local regeneration of cortisol by 11β-HSD1 contributes to insulin resistance of the granulosa cells in polycystic ovarian syndrome
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J Clin Endocrinol Metab
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2016
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May;101(5):2168-77
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Shuanggang Hu, Xiangqi Li, Chunhua Tang,, Yonglian Zhang.
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Isolation and characterization of detergent-resistant membranes from rat spermatozoa
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Asian Journal of Andrology
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2014
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16(5):790-791
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Shuanggang Hu, Guangxin Yao, Yang Wang, Haijing Xu, Xiaowei Ji, Yaqiong He, Qinling Zhu, Zijiang Chen,
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Transcriptomic changes during the pre-receptive to receptive transition in human endometrium detected by RNA-Seq
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J Clin Endocrinol Metab.
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2014
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99(12):E2744-53
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Shuang-Gang Hu, Mei Zou, Guang-Xin Yao, Wu-Bin Ma, Qin-Ling Zhu, Xiang-Qi Li, Zi-Jiang Chen,
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Androgenic regulation of beta-defensins in the mouse epididymis
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Reprod Biol Endocrinol
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2014
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12: 76
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, Xiao-li Qin; Bin Shan
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Differential Effects of CpG-TLR9 Axis on Pregnancy Outcome in Non-obese Diabetic Mice and Wild-type Controls
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Fertility and Sterility
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2013
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99（6）：1759-1767
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Shuanggang Hu, Guangxin Yao, Xiangqi Li, Zijiang Chen,
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Androgen receptor binding sites identified in mouse testis
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Acta Biochim Biophys Sin (Shanghai)
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2013
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45(9)：795-7
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, Wenjing Wang, Bin Shan, Jingfang Di, Linlin Chen, Lingling Ren, Weiping Li,Da-Jin Li, Yi Lin
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FTY720-Induced Conversion of Conventional Foxp3)CD4+ T Cells
to Foxp3+ Regulatory T Cells in NOD Mice
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American Journal of Reproductive Immunology
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2011
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66(5):349-62
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, Weiping Li, Zhengding Lu, Richard Chen,Jian Ling, Qitao Ran,
Robert L. Jilka, and Xiao-Dong Chen
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Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix
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The FASBE Journal
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2011
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25(5):1474-1485
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