- 基本信息
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导师姓名：
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姚玉峰
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学科代码：
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100100
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性别：
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男
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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Rm 710, Bldg 5, 280 S. Chongqing Rd, Shanghai, China 200025
Tel: 021-63846590-776523
Tel: 021-64671226
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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yfyao@sjtu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国微生物学会分析微生物专业委员会委员
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上海市微生物学会基础微生物专业委员会委员
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上海市微生物学会医学微生物专业委员会主任委员
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Review Editor of Frontiers in Cellular and Infection Microbiology
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美国微生物学会会员
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上海市微生物学会医学微生物专业委员会委员
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Editorial board member (Academic editor) of Microbial Cell
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- 科研项目
| 82272351 | L-阿拉伯糖促进沙门菌肠道定植和系统性感染的分子机制 | 国家自然科学基金 |
2023-01~2026-12
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52万元
| 课题负责人 |
| 81830068 | 蛋白质翻译后修饰调控沙门菌双组份系统PhoP/PhoQ机制及 意义 | 国家自然科学基金委重点项目 |
2019-01~2023-12
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294万元
| 课题负责人 |
| 81772140 | 乙酰化修饰调节沙门菌双组份系统PhoP磷酸化的机制及意义 | 国家自然科学基金 |
2018-01~2021-12
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56万元
| 课题负责人 |
| 2016YFA0500600 | 病原菌核糖体调节因子的发现、鉴定及调控机制研究 | 国家重点研发计划 |
2016-01~2020-12
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300万元
| 课题参与人 |
| 无 | 上海高校特聘教授(东方学者)跟踪计划 | 上海市教委 |
2015-01~2017-12
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100万元
| 课题负责人 |
| 15GWZK0102 | 传染病与卫生微生物学 | 上海市公共卫生三年行动计划重点学科建设项目 |
2015-01~2018-12
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22万元
| 课题参与人 |
| 2015CB554203 | 表观修饰与病原细菌适应性进化 | 科技部973计划 |
2015-01~2019-12
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300万元
| 课题负责人 |
| 81361120383 | 细胞壁脂类与耐利福平结核分枝杆菌致病性关系的研究 | 国家自然科学基金委面上项目 |
2014-01~2016-12
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180万元
| 课题负责人 |
| 31270173 | 肠出血型大肠埃希菌VI型分泌系统分泌蛋白鉴定及功能研究 | 国家自然科学基金委面上项目 |
2013-01~2016-12
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82万元
| 课题负责人 |
| 12QH1401300 | 结核分枝杆菌未知功能ABC超家族转运蛋白的研究 | 上海市科委，青年科技启明星(跟踪) |
2012-01~2014-12
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20万元
| 课题负责人 |
| 31070114 | 结核分枝杆菌DnaA乙酰化修饰与DNA复制调控的研究 | 国家自然科学基金委面上项目 |
2011-01~2013-12
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35万元
| 课题负责人 |
| 无 | 上海高校特聘教授(东方学者) | 上海市教委 |
2010-01~2012-12
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50万元
| 课题负责人 |
| 09QA1403600 | 结核分枝杆菌MazG功能研究及其与无毒株H37Ra表型的关系 | 上海市科委，青年科技启明星A |
2009-07~2011-06
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15万元
| 课题负责人 |
| 30870100 | 细胞毒素坏死因子(CNF1)的分泌及其作用机制 | 国家自然科学基金委面上项目 |
2009-01~2011-12
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30万元
| 课题负责人 |
| 2009CB522605 | 结核杆菌微进化的研究 | 科技部973计划 |
2009-01~2013-12
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320万元
| 课题负责人 |
- 学术论文
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Ni J, Li S, Lai Y, Wang Z, Wang D, Tan Y, Fan Y, Lu J,
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Global profiling of ribosomal protein acetylation reveals essentiality of acetylation homeostasis in maintaining ribosome assembly and function
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Nucleic Acids Res
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2023
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51(19):10411-10427
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Wang D, Ni J, Li J, Gao Y, Ni F, Zhang Z, Fang J, Lu J,
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Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation
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PLoS Pathog
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2023
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19(2):e1011189
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Zhang W, Lyu L, Xu Z, Ni J, Wang W, Lu L,
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Integrative DNA methylome and transcriptome analysis reveals DNA adenine methylation is involved in Salmonella enterica Typhimurium response to oxidative stress
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Microbiol Spectr
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2023
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e02479-23
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Sun Z, Zhou N, Zhang W, Xu Y,
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Dual role of CsrA in regulating the hemolytic activity of Escherichia coli O157:H7
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Virulence
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2022
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13(1): 859-74
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Wang Z, Zhu S, Li C, Lyu L, Yu J, Wang D, Xu Z, Ni J, Gao B, Lu J,
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Gene essentiality profiling reveals a novel determinant of stresses preventing protein aggregation in Salmonella
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Emerg Microbes Infect
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2022
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11(1): 1554-71
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Li J, Liu S, Su Y, Ren J, Sang Y, Ni J, Lu J*,
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Acetylation of PhoP K88 is involved in regulating Salmonella virulence
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Infect Immun
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2021
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89(3):e00588-20
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Su Y, Li J, Zhang W, Ni J, Huang R, Wang Z, Cheng S, Wang Y, Tian Z, Zhou Q, Lin D, Wu W, Tang CM, Liu X*, Lu J*,
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Methylation of PhoP by CheR regulates Salmonella virulence
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mBio
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2021
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12(5): e02099-21
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Zhou A, Li J, Xu Z, Ni J, Guo J,, Wu W*
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Whole-genome comparative and pathogenicity analysis of Salmonella enterica subsp. enterica serovar Rissen
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G3:Genes Genomes Genetics
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2020
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10(7):2159-70
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Ren J, Sang Y, Qin R , Su Y, Cui Z, Mang Z, Li H, Lu S, Zhang J, Cheng S, Liu X, Li J, Lu J, Wu W, Zhao GP, Shao F,
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Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation
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Emerg Microbes Infect
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2019
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8(1):55-69
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Xu Z, Zhou A, Wu J, Zhou A, Li J, Zhang S, Wu W, Karakousis PC,
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Transcriptional approach for decoding the mechanism of rpoC compensatory mutations for the fitness cost in rifampicin-resistant Mycobacterium tuberculosis
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Front Microbiol
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2018
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9:2895
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Yu X, Fu F, Kong W, Xuan Q, Wen D, Chen X, He Y, He L, Guo J, Zhou A, Xi Y, Ni L,, Wu W
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Streptococcus agalactiae inhibits Candida albicans hyphal development and diminishes host vaginal mucosal TH17 response
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Front Microbiol
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2018
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9:198
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Ren J, Sang Y, Lu J,
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Protein acetylation and its role in bacterial virulence
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Trends Microbiol
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2017
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25(9):768-779
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Li S, Zhang Q, Xu Z,
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Acetylation of lysine 243 inhibits the oriC binding ability of DnaA in Escherichia coli
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Front Microbiol
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2017
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8:699
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Wan B, Zhang Q, Ni J, Li S, Wen D, Li J, Xiao H, He P, Ou H, Tao J, Teng Q, Lu J, Wu W,
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Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS)
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PLoS Pathog
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2017
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e1006246
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Sang Y, Ren J, Qin R, Liu S, Cui Z, Cheng S, Liu X, Lu J, Tao J,
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Acetylation regulates protein stability and DNA-binding ability of HilD, thus modulating Salmonella Typhimurium virulence
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J Infect Dis
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2017
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216(8):0118-26
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Ren J, Sang Y, Lu J,
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6S RNA is involved in acid resistance and invasion of epithelial cells in Salmonella enterica serovar Typhimurium
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Future Microbiol
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2017
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12:1045-57
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Sang Y, Ren J, Ni J, Tao J, Lu J,
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Protein acetylation is involved in Salmonella enterica serovar Typhimurium virulence.
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J Infect Dis
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2016
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213(11):1836-45
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Qin R, Sang Y, Ren J, Zhang Q, Li S, Cui Z,
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The bacterial two-hybrid system uncovers the involvement of acetylation in regulating of Lrp activity in Salmonella Typhimurium
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Front Microbiol
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2016
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7:1864
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Ren J, Sang Y, Tan Y, Tao J, Ni J, Liu S, Fan X, Zhao W, Lu J, Wu W,
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Acetylation of lysine 201 inhibits the DNA-binding ability of PhoP to regulate Salmonella virulence
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PLoS Pathog
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2016
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e1005458
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Wan B, Zhang Q, Tao J, Zhou A,, Ni J
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Global transcriptional regulation by H-NS and its biological influence on the virulence of Enterohemorrhagic Escherichia coli
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Gene
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2016
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588(2):115-23
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Zhang Q, Zhou A, Li S, Ni J, Tao J, Lu J, Wan B, Li S, Zhang J, Zhao S, Zhao GP, Shao F,
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Reversible lysine acetylation is involved in DNA replication initiation by regulating activities of initiator DnaA in Escherichia coli
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Sci Rep
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2016
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6:30837
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Zhang Q, Wan B, Zhou A, Ni J, Xu Z, Li S, Tao J,
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Whole genome analysis of a multiple drug-resistant Beijing/W strain of Mycobacterium tuberculosis with large genomic deletions
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Gene
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2016
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582(2):128-36
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Tan Y, Xu Z, Tao J, Ni J, Zhao W, Lu J,
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A SIRT4-like auto ADP-ribosyltransferase is essential for the environmental growth of Mycobacterium smegmatis
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Acta Biochim Biophys Sin (Shanghai)
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2016
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48(2):145-52
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Zhou A, Ni J, Xu Z, Wang Y, Lu S, Wu W, Karakousis PC,
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Metabolomics specificity of tuberculosis plasma revealed by 1H-NMR spectroscopy
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Tuberculosis
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2015
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95(3):294-302
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Ren J, Sang Y, Lu J, Zhao M,
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Acetylation regulates survival in acid stress of Salmonella Typhimurium
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Appl Environ Microbiol
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2015
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81(17):5675-82
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Xu Z, Zhou A, Ni J, Zhang Q, Wang Y, Lu J, Wu W, Karakousis PC, Lu S,
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Differential expression of miRNAs and their relation to active tuberculosis
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Tuberculosis
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2015
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95(4):395-403
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Tao J, Sang Y, Teng Q, Ni J, Yang Y, Tsui S,
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Heat shock proteins IbpA and IbpB are required for NlpI-participated cell division in Escherichia coli.
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Front Microbiol
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2015
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6:51
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Zhou A, Ni J, Xu Z, Wang Y, Lu S, Sha W, Karakousis PC,
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Application of 1H-NMR spectroscopy-based metabolomics to sera of tuberculosis patients
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J Proteome Res
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2013
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12(10):4642-9
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Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo XK,
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Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells
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Infect & Immun
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2012
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80(3):1243-51
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Zhou A, Nawaz M, Duan Y, Moore J, Millar C, Xu J,
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Molecular characterization of isoniazid resistant Mycobacterium tuberculosis isolates from Xi’an, China
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Microb Drug Resist
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2011
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17(2):275-81
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Zhou A, Nawaz M, Xue X, Karakousis P,, Xu J
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Molecular genotyping study of Mycobacterium tuberculosis in Xi’an, China using MIRU-VNTR typing system
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Int J Tuberc Lung Dis
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2011
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15(4):517-22
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Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W,, Ning Z, Zeng R, Xiong Y, Guan K, Zhao S, Zhao G
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Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux
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Science
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2010
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327(5968):1004-7
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Lu LD, Sun Q, Fan XY, Zhong Y,, Zhao GP
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Mycobacterial MazG Is A Novel NTP Pyrophosphohydrolyase Involved in Oxidative Stress Response
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J Biol Chem
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2010
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285(36):28076-85
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, Xie Y, Perace D, Zhong Y, Lu J, Tao J, Guo X, Kim KS
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The type III secretion system is involved in the invasion and intracellular survival of Escherichia coli K1 in human brain microvascular endothelial cells
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FEMS Microbiol Lett
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2009
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300(1):18-24
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Parthasarathy G,, Kim KS
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Flagella promote Escherichia coli K1 association with and invasion of human brain microvascular endothelial cells (HBMEC)
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Infect & Immun
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2007
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75(6):2937-45
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, Xie Y, Kim KS
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Genomic comparison of E. coli K1 strains isolated from the cerebrospinal fluid of patients with meningitis
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Infect & Immun
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2006
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74(4):2196-206
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, Vuong C, Kocianova S, Villaruz A, Lai Y, Sturdevant D, Otto M
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Characterization of the Staphylococcus epidermidis accessory-gene regulator response: Quorum-sensing regulation of resistance to human innate host defense
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J Infect Dis
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2006
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193(6):841-8
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, Sturdevant D, Villaru A, Xu L, Gao Q, Otto M
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Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics
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Infect & Immun
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2005
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73(3):1856-60
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Kocianova S, Vuong C,, Carmody A, Otto M
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Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis
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J Clin Invest
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2005
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115(3):688-94
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, Sturdevant D, Otto M
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Genome-wide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into S. epidermidis biofilm pathophysiology
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J Infect Dis
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2005
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191(2):289-98
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Vuong C, Kocianova S,, Carmody AB, Otto M
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Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo
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J Infect Dis
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2004
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190(8):1498-505
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, Zhang WW, Jiao RS, Zhao GP, Jiang WH
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Efficient isolation of total RNA from antibiotic-producing bacterium Amycolatopsis mediterranei U32
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J Microbiol Meth
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2002
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51(2):191-5
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