• 基本信息
    导师姓名: 邓刘福 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: 上海市重庆南路280号西区5号楼1002室, 电话:021-54591053
    邮箱地址: dengliufu@shsmu.edu.cn 邮编: 200025
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    没有社会任职信息
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    8170280425-羟基胆甾醇(25-HC)与肿瘤放疗的协同免疫作用机制国家自然科学基金青年项目 2018-01~2020-12 20万元  课题参与人
    81771682cGAS-STING通路在肿瘤放疗中调节树突状细胞迁移和功能的机制研究国家自然科学基金面上项目 2018-01~2021-12 56万元  课题负责人
    16JC1406000PD-L1/PD-1抑制剂肿瘤治疗耐药新机制上海市科委基础研究重点项目 2016-07~2019-06 50万元  课题负责人
    第十二批国家“千人计划”青年人才天然免疫识别调节肿瘤免疫应答机制中组部“青年千人计划” 2016-01~2018-12 200万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Hou Y, Liang H, Rao E, Zheng W, Huang X,, Zhang Y, Yu X, Xu M, Mauceri H, Arina A, Weichselbaum RR, Fu YX  Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.  Immunity.  2018  S1074-7613(18)30328-5 
    Liang H,, Hou Y, Meng X, Huang X, Rao E, Zheng W, Mauceri H, Mack M, Xu M, Fu YX, Weichselbaum RR  Host STING-dependent MDSC mobilization drives extrinsic radiation resistance  Nat Commun.   2017  8(1):1736. 
    Weichselbaum RR, Liang H,, Fu YX  Radiotherapy and immunotherapy: a beneficial liaison?  Nat Rev Clin Oncol.  2017  14(6):365-379. 
    Xu MM, Pu Y, Han D, Shi Y, Cao X, Liang H, Chen X, Li XD,, Chen ZJ, Weichselbaum RR, Fu YX  Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling  Immunity  2017  47(2):363-373.e5 
    , Liang H, Fu S, Weichselbaum RR, Fu YX  From DNA Damage to Nucleic Acid Sensing: A Strategy to Enhance Radiation Therapy  Clin Cancer Res.  2016  22(1):20-5 
    Liu X, Pu Y, Cron K,, Kline J, Frazier WA, Xu H, Peng H, Fu YX, Xu MM  CD47 blockade triggers T cell-mediated destruction of immunogenic tumors  Nat Med.   2015  21(10):1209-15 
    , Liang H, Burnette B, Weicheslbaum RR, Fu YX  Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression  Oncoimmunology  2014  3:e28499 
    , Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, Huang X, Gajewski TF, Chen ZJ, Fu YX, Weichselbaum RR  STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors  Immunity  2014  41(5):843-52 
    , Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, Fu YX  Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice  J Clin Invest.  2014  124(2):687-95 
    Guo X, Qiu J, Tu T, Yang X,, Anders RA, Zhou L, Fu YX  Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection  Immunity  2014  40(1):25-39 
    Liang H,, Chmura S, Burnette B, Liadis N, Darga T, Beckett MA, Lingen MW, Witt M, Weichselbaum RR, Fu YX  Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing  J Immunol.   2013  190(11):5874-81 
    Liang H,, Burnette B, Weichselbaum RR, Fu YX  Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells  Oncoimmunology  2013  2(9):e25668 
    Upadhyay V, Poroyko V, Kim TJ, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP,, Nagler C, Chang EB, Tang H, Fu YX  Lymphotoxin regulates commensal responses to enable diet-induced obesity  Nat Immunol.   2012  13(10):947-53 
    , Zhang H, Luan Y, Zhang J, Xing Q, Dong S, Wu X, Liu M, Wang S  Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients  Clin Cancer Res.  2010  16(16):4105-12 
    Park S, Jiang Z, Mortenson ED,, Radkevich-Brown O, Yang X, Sattar H, Wang Y, Brown NK, Greene M, Liu Y, Tang J, Wang S, Fu YX  The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity  Cancer Cell  2010  18(2):160-70