• 基本信息
    导师姓名： 周广东 学科代码： 100210
    性别： 男 学科名称： 外科学
    培养单位： 附属第九人民医院 三级学科 整形
    导师类型： 博士生导师 专业领域名称：
    联系方式： guangdongzhou@126.com 专业领域代码：
    邮编： 200241 邮箱地址： guangdongzhou@126.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中国生物医学工程学会组织工程与再生医学分会副主任委员
    中国研究型医院学会运动医学分会副主任委员
    中国生物医学工程学会组织工程与再生医学分会-秘书长
    国家863计划产业开发类项目-评审专家
    中国生物医学工程学会组织工程与再生医学分会-常务委员
    《Biomaterials》杂志-审稿专家
    国家863计划项目评审专家
    中国生物3D打印产业联盟-理事
    中国生物材料学会再生材料分会-常委
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81871502JNK信号通路调控体外软骨再生机制及其应用7) 国家自然科学基金面上项目：、、2019/01-2022/12、57万、在研、项目负责人。 2019-01~2022-12 57万元  课题负责人
    18XD1421500软骨再生核心技术及其临床转化1) 上海市优秀技术带头人：、、2018/01-2020/12、40万元、在研、项目负责人。 2018-01~2020-12 40万元  课题负责人
    2017YFC1103900软骨-骨一体化功能支架研制及生物关节再生国家重点研发计划 2017-07~2020-12 1200万元  课题负责人
    201512组织工程软骨临床应用转化研究上海市卫生和计划生育委员会 2016-01~2020-12 45万元  课题负责人
    2016GGB14002自体骨髓基质干细胞构建组织工程软骨修复 关节软骨缺损的基础研究及临床应用山东省重点研发计划 2016-01~2018-12 10万元  课题负责人
    81571823人残耳软骨细胞体外构建人耳形态软骨及其体内转归国家自然科学基金 面上项目 2016-01~2019-12 58万元  课题负责人
    15DZ1941600组织工程耳廓形态软骨耳再造临床新技术上海市科委产学研医合作 2015-07~2018-06 100万元  课题负责人
    201501泰山学者特聘教授山东省人民政府 2015-01~2020-12 200万元  课题负责人
    81371703LOX激活及力学刺激提高体外构建软骨的力学强度国家自然科学基金面上项目 2014-01~2017-12 70万元  课题负责人
    13DZ0503100临床组织工程技术平台设置标准研究上海市科委标准专项课题 2013-07~2016-06 40万元  课题负责人
    201214组织工程化软骨的基础及临床转化研究上海市领军人才后备队培养计划 2013-01~2015-12 30万元  课题负责人
    2012AA020507结构类组织的组织工程构建技术与产品开发科技部，国家863计划重大课题 2012-01~2015-12 1294万元  子课题负责人
    XBR2011050基于体外构建技术的组织工程软骨临床应用转化上海市卫生局，优秀学科带头人 2011-01~2015-12 100万元  课题负责人
    NCET-09-0561骨髓基质干细胞体外构建人耳廓形态软骨教育部，新世纪优秀人才 2010-01~2012-12 50万元  课题负责人
    30973131骨髓基质干细胞体外构建人耳廓形态软骨国家自然基金委,面上项目 2010-01~2012-12 35万元  课题负责人
    09QH1401600骨髓基质干细胞体外构建人耳廓形态软骨上海市科委,启明星跟踪 2009-07~2011-06 20万元  课题负责人
    50830105组织工程功能支架材料及有序血管网络的构建国家自然基金委,重点项目 2009-01~2012-12 180万元  子课题负责人
    08SG19应用干细胞体外构建个性化人耳廓形态软骨上海市教育发展基金会 2009-01~2011-12 15万元  课题负责人
    30772264脂肪干细胞软骨潜能亚群的特异性分子标志国家自然基金委,面上项目 2008-01~2010-12 28万元  课题负责人
    2006AA02A126基于成体干细胞体外构建的组织工程软骨产品研发科技部，国家863计划重大课题 2006-12~2010-12 474万元  课题负责人
    05QMX1427脂肪干细胞生物学特性及纯化技术研究上海市科委,启明星 2005-09~2008-09 10万元  课题负责人
    2005CB522702组织微环境对干细胞形成特定组织的影响及其作用机制科技部，国家973计划课题 2005-09~2010-10 560万元  课题负责人
    2002AA205021组织微环境对干细胞形成组织工程化软骨构建的相关技术研究与产品开发科技部，国家863计划重大课题 2002-11~2005-12 560万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Yingying Huo , Baoshuai Bai, Rui Zheng, Yuyan Sun, Yao Yu , Xin Wang , Hong Chen, Yujie Hua, Yixin Zhang,, Xiaoyun Wang  In Vivo Stable Allogenic Cartilage Regeneration in a Goat Model Based on Immunoisolation Strategy Using Electrospun Semipermeable Membranes  Adv Healthc Mater  2023  2023;12(13):e2203084 
    Qianyi Wang, Xinyue Ran, Jian Wang, Sinan Wang, Peiling Zhang, Erji Gao, Baoshuai Bai, Junfeng Zhang,, Dong Lei  Elastic Fiber-Reinforced Silk Fibroin Scaffold with A Double-Crosslinking Network for Human Ear-Shaped Cartilage Regeneration  Adv. Fiber Mater  2023  5, 1008–1024 (2023) 
    Tao Wang, Wei Xu, Xintong Zhao, Baoshuai Bai, Yuejie Hua, Jincheng Tang, Feifan Chen, Yu, Liu,, Guangdong Zhou, Yilin Cao  Repair of Osteochondral Defects Mediated by Double-Layer Scaffolds with Natural Osteochondral-Biomimetic Microenvironment and Interface  Materials Today Bio  2022  2022.03,14:100234 
    Xiaodi Wu, Yingying Huo, Zheng Ci, Yahui Wang, Wei Xu, Baoshuai Bai, Junxiang Hao, Guanhuai Hu, Mengyuan Yu, Wenjie Ren, Yixin Zhang, Yujie Hua,  Biomimetic porous hydrogel scaffolds enabled eascular ingrowth and osteogenic differentiation for vascularized tissue-engineered bone regeneration  Applied Materials Today  2022  2022.06, 27:101478 
    Jia L,Zhang Y,Yao L,Zhang P,Ci Z, Zhang W,Miao C, Liang X, He A, Liu Y,Tang S, Zhang R,*Wang X, *Cao Y,  Regeneration of human-ear-shaped cartilage with acellular cartilage matrix-based biomimetic scaffolds  Applied Materials Today  2020  20:p.10063 
    Xu Y,Jia L,Wang Z,Jiang G,,*Chen W,*Chen R  Injectable photo-crosslinking cartilage decellularized extracellular matrix for cartilage tissue regeneration  Materials Letters  2020  268:127609 
    Chen W, Xu Y, Li Y, Jia L, *Mo X, *Jiang G,  3D printing electrospinning fiber-reinforced decellularized extracellular matrix for cartilage regeneration  Chemical Engineering Journal  2020  382: p. 122986 
    Xu Y,Guo Y, Li Y,Huo Y, She Y,Li H, Jia Z, Jiang G,,* You Z,*Duan L  Biomimetic Trachea Regeneration Using a Modular Ring Strategy Based on Poly(Sebacoyl Diglyceride)/ Polycaprolactone for Segmental Trachea Defect Repair.Advanced Functional Materials   Biomimetic Trachea Regeneration Using a Modular Ring Strategy Based on Poly(Sebacoyl Diglyceride)/ Polycaprolactone for Segmental Trachea Defect Repair.Advanced Functional Materials   2020  2004276:P.1-14 
    Xu Y,Xu Y,Bi B, Hou M, Yao L, Du Q, He A,Liu Y, Miao C,Liang X,*Jiang X,,*Cao Y  A moldable thermosensitive hydroxypropyl chitin hydrogel for 3D cartilage regeneration in vitro and in vivo  Acta Biomaterialia  2020  108:87-96 
    Yin Z,Li D,Liu Y,Feng S,Yao L,Liang X,Miao C,Xu Y,Hou M,Zhang R,Zhang W,Liu W,*Liu Y,,*Cao Y  Regeneration of elastic cartilage with accurate human-ear shape based on PCL strengthened biodegradable scaffold and expanded microtia chondrocytes.  Applied Materials Today  2020  20:100724 
    Chen WM , Xu Y , Liu YQ,Wang ZX , Li YQ , Jiang GN , Mo XM ,,GD   Three-dimensional printed electrospun fiber-based scaffold for cartilage regeneration  MATERIALS & DESIGN  2019  179(2019)107886 
    Liu Y,Xu Y,Zhang Z, Huo Y , Chen D , Ma W , Sun K , Tonga GY ,, Kohane DS , Tao K .  A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose  Nano letters  2019  19(8):5515-5523 
    Li D, Yin Z, Liu Y , Feng S, Liu Y , Lu F , Xu Y , Min P , Hou M , Li K , He A , Zhang W , Liu W , *Zhang Y ,,*Cao Y .  Regeneration of trachea graft with cartilage support, vascularization, and epithelization  Acta biomaterialia  2019  89():206-216 
    Wang F, Hu Y, He D,, Edward III Ellis  Scaffold-free cartilage cell sheet combined with bone-phase BMSCs-scaffold regenerate osteochondral construct in mini-pig model.   Am J Transl Res  2018  10(10):2997-3010.  
    Xue J, He A, Zhu Y, Liu Y, Li D, Yin Z, Zhang W, Liu W, Cao Y,  Repair of articular cartilage defects with acellular cartilage sheets in a swine model  Biomed Mater  2018  13(2):025016 
    Zhang Y, Xu Y, Liu Y, Dan Li, Yin Z, Huo Y, Jiang G, Yang Y, Wang Z, Li Y, Lu F, Liu Y, *Duan L,  Porous decellularized trachea scaffold prepared by a laser micropore technique  J Mech Behav Biomed Mater  2018  90:96-103 
    Liu Y, Xu Y, Geng X, Huo Y, Chen D, *Sun K,, Chen B, *Tao K.   Synergistic Targeting and Efficient Photodynamic Therapy Based on Graphene Oxide Quantum Dot-Upconversion Nanocrystal Hybrid Nanoparticles  Small  2018  14(19):e1800293 
    Xia H, Zhao D, Zhu H, Hua Y, Xiao K, Xu Y, Liu Y, Chen W, Liu Y, Zhang W, Liu W, Tang S, Cao Y, *Wang X, *Chen H,  Lyophilized Scaffolds Fabricated from 3D-Printed Photocurable Natural Hydrogel for Cartilage Regeneration  ACS Appl Mater Interfaces  2018  10(37):31704-31715.  
    Feng C, Luo X, He N, Xia H, Lv X, Zhang X, Li D, Wang F, He J, Zhang L, Lin X, Lin L, Yin H, He J, Wang J , Cao W, Wang R,, *Wang W. .  Efficacy and Persistence of Allogeneic Adipose-Derived Mesenchymal Stem Cells Combined with Hyaluronic Acid in Osteoarthritis After Intra-articular Injection in a Sheep Model  Tissue Eng Part A.  2018  24(3-4):219-233 
    , Jiang H, Yin Z, Liu Y, Zhang Q, Zhang C, Pan B, Zhou J, Zhou X, Sun H, Li D, He A, Zhang Z, Zhang W, Liu W, Cao Y.   In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction.   EBioMedicine  2018  28:287-302. 
    He A, Xia H, Xiao K, Wang T, Liu Y, Xue J, Li D, Tang S, Liu F, *Wang X, Zhang W, Liu W, *Cao Y,  Cell yield, chondrogenic potential, and regenerated cartilage type of chondrocytes derived from ear, nasoseptal, and costal cartilage  J Tissue Eng Regen Med  2018  12(4):1123-1132 
    Wang H, Dai T, Li S, Zhou S, Yuan X, You J, Wang C, Mukwaya V,, Liu G,Wei X, *Dou H.  Scalable and cleavable polysaccharide nanocarriers for the delivery of chemotherapy drugs  Acta Biomater  2018  72:206-216 
    Li D, Zhu L, Liu Y, Yin Z, Liu Y, Liu F, He A, Feng S, Zhang Y, Zhang Z, Zhang W, Liu W, Cao Y,  Stable subcutaneous cartilage regeneration of bone marrow stromal cells directed by chondrocyte sheet  Acta Biomater  2017  54:321-332 
    Chen D, Tao R, Tao K, Chen B, Choi SK, Tian Q, Xu Y,, *Sun K  Efficacy Dependence of Photodynamic Therapy Mediated by Upconversion Nanoparticles: Subcellular Positioning and Irradiation Productivity  Small  2017  13(13) 
    Xu Y, Li D, Yin Z, He A, Lin M, Jiang G, Song X, Hu X, Liu Y, Wang J, *Wang X, *Duan L,  Tissue-engineered trachea regeneration using decellularized trachea matrix treated with laser micropore technique   Acta Biomater  2017  58:113-121 
    He A, Liu L, Luo X, Liu Y, Liu Y, Liu F, Wang X*, Zhang Z, Zhang W, Liu W, *Cao Y,  Repair of osteochondral defects with in vitro engineered cartilage based on autologous bone marrow stromal cells in a swine model  Scientific Reports  2017  7:40489 
    Feng C, Luo X, He N, Xia H, Lv X, Zhang X, Li D, Wang F, He J, Zhang L, Lin X, Lin L, Yin H, He J, Wang J, Cao W, Wang R,, *Wang W  Efficacy and persistence of allogeneic adipose-derived mesenchymal stem cells combined with hyaluronic acid in osteoarthritis after intra-articular injection in a sheep model  Tissue Eng Part A  2017  1-36 
    Wang H, Dai T, Zhou S, Huang X, Li S, Sun K,, *Dou H  Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems  Sci Rep  2017  7:40011 
    Chen J,Yuan Z, Liu Y, Zheng R, Dai Y, Tao R, Xia H, Liu H, Zhang Z, Zhang W, Liu W, Cao Y,  Improvement of In Vitro Three-Dimensional Cartilage Regeneration by a Novel Hydrostatic Pressure Bioreactor  Stem Cells Transl Med  2016  6(3):982-991 
    Liao HT, Zheng R, Liu W, Zhang WJ, *Cao Y,  Prefabricated, Ear-shaped Cartilage Tissue Engineering by Scaffold-free Porcine Chondrocytes Membrane  Plast Reconstr Surg  2015  135(2): 313-321 
    Zhu Y, Zhang Y, Liu Y, Tao R, Xia H, Zheng R, Shi Y, Tang S, Zhang W, Liu W, *Cao Y,  Influence of Chm-I knockout on ectopic cartilage regeneration and homeostasis maintenance  Tissue Eng Part A  2015  21(3-4):782-792 
    Dai T, Zhou S, Yin C, Li S, Cao W, Liu W, Sun K, *Dou H, *Cao Y, *Zhou G.  Dextran-based fluorescent nanoprobes for sentinel lymph node mapping  Biomaterials   2014  35(28):8227-35 
    Zhang L, He A, Yin Z, Yu Z, Luo X, Liu W, Zhang W, Cao Y, *Liu Y,  Regeneration of human-ear-shaped cartilage by co-culturing human microtia chondrocytes with BMSCs  Biomaterials  2014  35(18):4878-87 
    Luo X, Liu Y, Zhang Z, Tao R, Liu Y, He A, Yin Z, Li D, Zhang W, Liu W, *Cao Y,  Long-term functional reconstruction of segmental tracheal defect by pedicled tissue-engineered trachea in rabbits  Biomaterials  2013  34(13):3336-44 
    Ding C, Qiao Z, Jiang W, Li H, Wei J,, *Dai K  Regeneration of a goat femoral head using a tissue-specific, biphasic scaffold fabricated with CAD/CAM technology.  Biomaterials  2013  34(28):6706-16 
    Zheng R, Duan H, Xue J, Liu Y, Feng B, Zhao S, Zhu Y, Liu Y, He A, Zhang W, Liu W, *Cao Y,  The influence of Gelatin/PCL ratio and 3-D construct shape of electrospun membranes on cartilage regeneration  Biomaterials  2013  35(1):152-64 
    Zhang Y, Yang F, Liu K, Shen H, Zhu Y, Zhang W, Liu W, Wang S, Cao Y,  The impact of PLGA scaffold orientation on in vitro cartilage regeneration.   Biomaterials.  2012  33(10):2926-35 
    Spiller KL, Liu Y, Holloway JL, Maher SA, Cao Y, Liu W,, Lowman AM  A novel method for the direct fabrication of growth factor-loaded microspheres within porous PVA hydrogels: Controlled release for cartilage tissue engineering.  J Control Release.  2012  157(1):39-45 
    Jiang Y, Liu H, Li H, Wang F, Cheng K,, Zhang W, Ye M, Cao Y, Liu W, Zou H.  A proteomic analysis of engineered tendon formation under dynamic mechanical loading in vitro.   Biomaterials.  2011  32(17):4085-95. 
    Sun H, Liu W,, Zhang W, Cui L, Cao Y.  Tissue engineering of cartilage, tendon and bone.  Front Med.  2011  5(1):61-9. 
    Gong YY, Xue JX, Zhang WJ,, Liu W, Cao Y.  A sandwich model for engineering cartilage with acellular cartilage sheets and chondrocytes.   Biomaterials.  2011  32(9):2265-73. 
    Li Q, Liu T, Zhang L, Liu Y, Zhang W, Liu W, Cao Y,  The role of bFGF in down-regulating α-SMA expression of chondrogenically induced BMSCs and preventing the shrinkage of BMSC engineered cartilage.  Biomaterials.  2011  32(21):4773-81. 
    Liu Y, Zhang L,, Li Q, Liu W, Yu Z, Luo X, Jiang T, Zhang W, Cao Y.  In vitro engineering of human ear-shaped cartilage assisted with CAD/CAM technology  Biomaterials  2010  31(8):2176-83 
    Yue W, Pi QM, Zhang WJ,, Cui L, Liu W, Cao Y.  Platelet endothelial cell adhesion molecule-1, stage-specific embryonic antigen-1, and Flk-1 mark distinct populations of mouse embryonic stem cells during differentiation toward hematopoietic/endothelial cells.  Stem Cells Dev.  2010  19(12):1937-48. 
    Zhu J, Li J, Wang B, Zhang WJ,, Cao Y, Liu W.  The regulation of phenotype of cultured tenocytes by microgrooved surface structure.   Biomaterials.  2010  31(27):6952-6958. 
    Liu X, Sun H, Yan D, Zhang L, Lv X, Liu T, Zhang W, Liu W, Cao Y,  In vivo ectopic chondrogenesis of BMSCs directed by mature chondrocytes.  Biomaterials.  2010  31(36):9406-14 
    Wu Y, Zhu L, Jiang H, Liu W, Liu Y, Cao Y,  Engineering cartilage substitute with a specific size and shape using porous high-density polyethylene (HDPE) as internal support.   J Plast Reconstr Aesthet Surg.  2010  63(4):e370-5. 
    Dai T, Jiang Z,, Zhou G, Kretlow JD, Cao W, Liu W, Cao Y.  Reconstruction of lymph vessel by lymphatic endothelial cells combined with polyglycolic acid scaffolds: a pilot study.  J Biotechnol.  2010  150(1):182-9. 
    Jiang T, Liu W, Lv X, Sun H, Zhang L, Liu Y, Zhang WJ, Cao Y,  Potent in vitro chondrogenesis of CD105 enriched human adipose-derived stem cells.  Biomaterials  2010  31(13):3564-71 
    Zhu L, Wu Y, Jiang H, Liu W, Cao Y,  Engineered cartilage with internal porous high-density polyethylene support from bone marrow stromal cells: A preliminary study in nude mice.   Br J Oral Maxillofac Surg.  2010  48(6):462-5. 
    Luo X,, Liu W, Zhang WJ, Cen L, Cui L, Cao Y  In vitro precultivation alleviates post-implantation inflammation and enhances development of tissue-engineered tubular cartilage.  Biomed Mater.  2009  4(2):025006. 
    Yan D,, Zhou X, Liu W, Zhang WJ, Luo X, Zhang L, Jiang T, Cui L, Cao Y.  The impact of low levels of collagen IX and pyridinoline on the mechanical properties of in vitro engineered cartilage.   Biomaterials.  2009  30(5):814-21. 
    Liu K,, Liu W, Zhang WJ, Cui L, Liu X, Liu TY, Cao Y.  The dependence of in vivo stable ectopic chondrogenesis by human mesenchymal stem cells on chondrogenic differentiation in vitro.   Biomaterials.  2008  29(14):2183-92. 
    Liu K,, Liu W, Zhang WJ, Cui L, Liu X, Liu TY, Cao Y.  In vitro formation of lacuna structure by human dermal fibroblasts co-cultured with porcine chondrocytes on a 3D biodegradable scaffold.   Biotechnol Lett.  2007  29(11):1685-90. 
    , Liu W, Cui L, Wang X, Liu T, Cao Y.  Repair of porcine articular osteochondral defects in non-weightbearing areas with autologous bone marrow stromal cells.   Tissue Eng.  2006  12(11):3209-21 
    Lu M,, Liu W, Wang Z, Zhu Y, Yu B, Zhang W, Cao Y.  Remodeling of buccal mucosa by bladder microenvironment.   Key Eng Mater.  2005  3(6): 288-289