• 基本信息
    导师姓名: 聂红 学科代码: 100100
    性别: 学科名称: 基础医学
    培养单位: 基础医学院 三级学科
    导师类型: 博士生导师 专业领域名称:
    联系方式: 021-63846590-776364 专业领域代码:
    邮编: 200025 邮箱地址: hnie0823@126.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海交通大学医学院免疫学与微生物学系副主任
    上海市中医药学会第十届风湿病分会委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81671590CD8+CXCR3+T细胞调控Tfh细胞功能的分子机制及其在系统性红斑狼疮中作用的机制研究国家自然科学基金面上项目 2017-01~2020-12 57万元  课题负责人
    2014CB541803遗传变异调控AS自身免疫紊乱的分子机制研究科技部973课题 2014-01~2018-12 110万元  课题参与人
    14ZZ106IL-7/IL-7R调控类风关滑膜炎症和骨破坏分子机制研究上海市教委创新基金重点项目 2014-01~2016-12 16万元  课题负责人
    81273307阻断IL-7/IL-7R信号通路治疗类风关细胞与分子机制研究国家自然科学基金面上项目 2013-01~2016-12 75万元  课题负责人
    81072470TNFa下调类风关Treg细胞磷酸化Foxp3表达及促进Th17细胞分化机制研究国家自然科学基金面上项目 2011-01~2013-12 30万元  课题负责人
    30872304Qa-1限制性调节性CD8+T细胞系建立、特性及效应机制研究国家自然科学基金面上项目 2009-01~2011-12 26万元  课题负责人
    09YZ102Qa-1限制性调节性CD8+T细胞系建立及其生物学特性研究上海市教委创新基金 2009-01~2011-12 8万元  课题负责人
    2008XJ005抗TNF-a抗体治疗类风关分子机制研究医学院基金 2008-07~2010-06 5万元  课题负责人
    2008HX006EGCG对胶原诱导的关节炎免疫调节机理研究横向课题 2008-01~2009-10 5万元  课题负责人
    06BZ022EGCG和Andro联合用药治疗RA作用机制研究上海市教委发展基金 2007-01~2008-12 6万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Jiang Y, Chen M,, Yuan Y  PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations  Human Vaccines & Immunotherapeutics  2019  1571892 
    Wei W, Wang Y, Sun Q, Jiang C, Zhu M, Song C, Li C, Du G, Deng Y,, Tang G.  Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus  J Oral Pathol Med  2019  doi: 10.1111/jop.12938 
    Xu H, Cai L, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y,  Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-kB signalling pathway in osteoclast differentiation  Immunology  2018  154: 593-603 
    Wang Y, Shang S, Sun Q, Chen J, Du G,, Han X, Tang G  Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus  Oral Surg Oral Med Oral Pathol Oral Radiol.   2018  125(5):459-467 
    Wei J, Wu J, Xu W,, Zhou R, Wang R, Liu Y, Tang G, Wu J.   Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1?signaling pathway  Cell Death Dis  2018  9(6): 599 
    Zheng Y, Huang L, Ge W, Yang M, Ma Y, Xie G, Wang W, Bian B, Li L,, Shen L.   Protein arginine methyltransferase 5 inhibition upregulates Foxp3+ regulatory T cells frequency and function during the ulcerative colitis  Front Immunol  2017  8: 596 
    Han Zhang, Yuanyuan Qi, Yuanyang Yuan, Li Cai, Haiyan Xu, Lili Zhang, Bing Su,  Paeoniflorin ameliorates experimental autoimmune encephalomyelitis via inhibition of dendritic cell function and Th17 cell differentiation.  Sci Rep  2017  7: 41887 
    Li Cai, Haiyan Xu, Han Zhang, Lili Zhang, Guojue Wang,  Blockade of IL-7Rα alleviates collagen-induced arthritis via inhibiting Th1 cell differentiation and CD4+ T cell migration.  Mol Immunol.   2016  79: 83-91 
    Zheng Y, Sun L, Jiang T, Zhang D, He D,  TNFa promotes Th17 cell differentiation through IL-6 and IL-1b produced by monocytes in rheumatoid arthritis  J Immunol Res  2014  385352:1-12 
    Quanye Sun,Yingxia Zheng, Xia Zhang, Xiaojuan Hu, Yuanxia Wang, Shimin Zhang, Dongqing Zhang,  Novel immunoregulatory properties of EGCG on reducing inflammation in EAE  Frontiers in Bioscience, Landmark  2013  18:332-342 
    , Yingxia Zheng, Runsheng Li, Taylor B Guo, Dongyi He, Lei Fang, Xuebin Liu, Lianbo Xiao, Xi Chen, Bing Wan, Y Eugene Chin, Jingwu Z Zhang   Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis  Nat. Med.  2013  19(3): 322-328 
    Qianqian Yin, Chuanxu Liu, Yingli Wu, Shaofang Wu, Yan Wang, Xia Zhang, Xiaojuan Hu, Jianxin Pu, Ying Lu, Huchen Zhou, Honglin Wang,, Handong Sun, Guoqiang Chen.  Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-?B signaling  J Immunol  2013  191(5): 2115-2125 
    Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng,, Min Jin, Huanbai Xu   Stimulation of TLR4 by LMW-HA induces metastasis in human papillary thyroid carcinoma through CXCR7  Clin Dev Immunol  2013  712561:1-9 
    Chaoying Hu, Liu Qian, Yi Miao, Qiuyu Huang, Ping Miao, Ping Wang, Qiwen Yu,, Jiying Zhang, Dongyi He, Rong Xu, Xuehua Chen, Bingya Liu, Dongqing Zhang.  Antigen-presenting effects of effector memory V?9V?2 T cells in rheumatoid arthritis  Cell Mol Immunol  2012  9(3):245-54 
    Chen M, Chen G,, Zhang X, Niu X, Zang YC, Skinner SM, Zhang JZ, Killian JM, Hong J  Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4(+) T Cells in MS  Eur J Immunol  2009  39(9):2525-2536 
    Gong F, Ma Y, Ma A, Yu Q, Zhang J,, Chen X, Shen B, Li N, Zhang D  A lectin from Chinese mistletoe increases gammadelta T cell-mediated cytotoxicity through induction of caspase-dependent apoptosis  Acta Biochim Sin  2007  39:445-452 
    , Jiliang Wu, Miao Zhang, Jian Xu, Minghui Zou  Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo  Diabetes  2006  55(11):3133-3141 
    Jian Hong, Ying Zang,, and Jingwu Z. Zhang  CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis  PNAS  2006  103(13):5024-5029 
    Bin Wan,, Ailian Liu, Guozhang Feng, Dongyi He, Rong Xu, Qi Zhang, Chen Dong, Jingwu Z. Zhang  Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis  J Immunol  2006  177(12): 8844-8850 
    Guangwu Xu,, Ningli Li, Wenxin Zheng, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Jian Hong, and Jingwu Z. Zhang  Role of osteopontin in amplification and perpetuation of rheumatoid synovitis  J Clin Invest  2005  115(4):1060-1067 
    Guangwu Xu, Wei Sun, Dongyi He, Li Wang, Wenxin Zheng,, Liqing Ni, Dongqing Zhang, Ningli Li, Jingwu Zhang  Overexpression of osteopontin in rheumatoid synovial mononuclear cells is associated with joint inflammation, not with genetic polymorphism  J Rheumatol  2005  32(3): 410-416 
    Wei Sun,, Ningli Li, Ying C.Q. Zang, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, S Prasad, RR Robinson, W Ho, E Sercarz, and JZ Zhang  Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis  Genes Immun  2005  6(3):248-261 
    Ningli Li,, Qiwen Yu, Jiying Zhang, Anlun Ma, Baihua Shen, Li Wang, Jun Bai, Xuehua Chen, Tong Zhou, Dongqing Zhang  The role of sFasL in autoimmune disease.  W.J.Gastregon  2004  10(21): 3151-3156