- 基本信息
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导师姓名：
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聂红
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学科代码：
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100100
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性别：
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女
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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021-63846590-776364
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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hnie0823@126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海交通大学医学院免疫学与微生物学系副主任
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上海市中医药学会第十届风湿病分会委员
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- 科研项目
| 20ZR1448900 | PRMT5促进宫颈癌PD-L1表达及抑制肿瘤浸润T细胞功能的细胞和分子机制 | 上海市科委 |
2022-07~2023-06
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20万元
| 课题负责人 |
| 2019YFA0111003 | 利用新型 CAR-T 治疗复发难治 T 细胞淋巴瘤的临床研究 | 国家重点研发计划 |
2019-11~2023-12
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126万元
| 课题参与人 |
| 81671590 | CD8+CXCR3+T细胞调控Tfh细胞功能的分子机制及其在系统性红斑狼疮中作用的机制研究 | 国家自然科学基金面上项目 |
2017-01~2020-12
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57万元
| 课题负责人 |
| 2014CB541803 | 遗传变异调控AS自身免疫紊乱的分子机制研究 | 科技部973课题 |
2014-01~2018-12
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110万元
| 课题参与人 |
| 14ZZ106 | IL-7/IL-7R调控类风关滑膜炎症和骨破坏分子机制研究 | 上海市教委创新基金重点项目 |
2014-01~2016-12
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16万元
| 课题负责人 |
| 81273307 | 阻断IL-7/IL-7R信号通路治疗类风关细胞与分子机制研究 | 国家自然科学基金面上项目 |
2013-01~2016-12
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75万元
| 课题负责人 |
| 81072470 | TNFa下调类风关Treg细胞磷酸化Foxp3表达及促进Th17细胞分化机制研究 | 国家自然科学基金面上项目 |
2011-01~2013-12
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30万元
| 课题负责人 |
| 30872304 | Qa-1限制性调节性CD8+T细胞系建立、特性及效应机制研究 | 国家自然科学基金面上项目 |
2009-01~2011-12
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26万元
| 课题负责人 |
- 学术论文
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Xu H, Cai L, Li Z, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y,
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Dual effect of IL-7/IL-7R signalling on the osteoimmunological system: a potential therapeutic target for rheumatoid arthritis
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Immunology
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2021
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164(1):161-172
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Yuan Y,
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Protein arginine methyltransferase 5: a potential cancer therapeutic target
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Cell Oncol (Dordr)
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2021
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44(1):33-44
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Wang Z, Li Z, Wang G, Sun Y, Yuan Y,
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Salubrinal alleviates collagen-induced arthritis through promoting P65 degradation in osteoclastogenesis
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Int J Mol Sci
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2021
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22(7):3501
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Duan W, Sun Y, Wu M, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T,, Cheng J
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Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis
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Eur J Med Chem
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2021
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226:113878
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Jiang Y, Yuan Y, Chen M, Li S, Bai J, Zhang Y, Sun Y, Wang G, Xu H, Wang Z, Zheng Y,
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PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression
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Theranostics
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2021
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11(18):9162-9176
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Jiang Y, Chen M,, Yuan Y
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PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations
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Human Vaccines & Immunotherapeutics
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2019
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1571892
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Yang L, Chen S, Zhao Q, Sun Y,
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The Critical role of Bach2 in shaping the balance between CD4+ T cell subsets in immune-mediated diseases
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Mediators Inflamm
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2019
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2609737
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Wei W, Wang Y, Sun Q, Jiang C, Zhu M, Song C, Li C, Du G, Deng Y,, Tang G.
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Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus
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J Oral Pathol Med
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2019
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doi: 10.1111/jop.12938
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Xu H, Cai L, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y,
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Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-kB signalling pathway in osteoclast differentiation
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Immunology
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2018
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154: 593-603
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Wang Y, Shang S, Sun Q, Chen J, Du G,, Han X, Tang G
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Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus
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Oral Surg Oral Med Oral Pathol Oral Radiol.
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2018
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125(5):459-467
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Wei J, Wu J, Xu W,, Zhou R, Wang R, Liu Y, Tang G, Wu J.
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Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1?signaling pathway
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Cell Death Dis
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2018
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9(6): 599
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Zheng Y, Huang L, Ge W, Yang M, Ma Y, Xie G, Wang W, Bian B, Li L,, Shen L.
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Protein arginine methyltransferase 5 inhibition upregulates Foxp3+ regulatory T cells frequency and function during the ulcerative colitis
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Front Immunol
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2017
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8: 596
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Han Zhang, Yuanyuan Qi, Yuanyang Yuan, Li Cai, Haiyan Xu, Lili Zhang, Bing Su,
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Paeoniflorin ameliorates experimental autoimmune encephalomyelitis via inhibition of dendritic cell function and Th17 cell differentiation.
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Sci Rep
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2017
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7: 41887
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Li Cai, Haiyan Xu, Han Zhang, Lili Zhang, Guojue Wang,
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Blockade of IL-7Rα alleviates collagen-induced arthritis via inhibiting Th1 cell differentiation and CD4+ T cell migration.
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Mol Immunol.
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2016
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79: 83-91
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Zheng Y, Sun L, Jiang T, Zhang D, He D,
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TNFa promotes Th17 cell differentiation through IL-6 and IL-1b produced by monocytes in rheumatoid arthritis
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J Immunol Res
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2014
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385352:1-12
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Quanye Sun,Yingxia Zheng, Xia Zhang, Xiaojuan Hu, Yuanxia Wang, Shimin Zhang, Dongqing Zhang,
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Novel immunoregulatory properties of EGCG on reducing inflammation in EAE
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Frontiers in Bioscience, Landmark
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2013
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18:332-342
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, Yingxia Zheng, Runsheng Li, Taylor B Guo, Dongyi He, Lei Fang, Xuebin Liu,
Lianbo Xiao, Xi Chen, Bing Wan, Y Eugene Chin, Jingwu Z Zhang
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Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis
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Nat. Med.
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2013
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19(3): 322-328
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Qianqian Yin, Chuanxu Liu, Yingli Wu, Shaofang Wu, Yan Wang, Xia Zhang, Xiaojuan Hu, Jianxin Pu, Ying Lu, Huchen Zhou, Honglin Wang,, Handong Sun, Guoqiang Chen.
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Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-?B signaling
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J Immunol
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2013
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191(5): 2115-2125
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Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng,, Min Jin, Huanbai Xu
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Stimulation of TLR4 by LMW-HA induces metastasis in human papillary thyroid carcinoma through CXCR7
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Clin Dev Immunol
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2013
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712561:1-9
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