• 基本信息
    导师姓名: 皋源 学科代码: 100218
    性别: 学科名称: 急诊医学
    培养单位: 附属仁济医院 三级学科
    导师类型: 博士生导师 专业领域名称: 急诊医学 专业学位
    联系方式: 021-68383162 专业领域代码: 105107
    邮编: 200127 邮箱地址: gaoyuanzhuren@126.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海医师协会重症医师分会副会长
    中国医师协会重症医学分会委员
    中华医学会肠外肠内营养学会重症学组委员
    中国病理生理学会危重病医学专业委员会常务委员
    中华医学会重症医学分会常务委员
    上海医学会危重病专委会候任主任委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    82372186液-液相分离诱导肺泡上皮细胞铁自噬-铁死亡及铁蛋白-EV分泌活化肺 成纤维细胞促进机械通气相关性肺纤维化的机制国家自然科学基金面上项目 2024-01~2027-12 49万元  课题负责人
    82172150机械牵张微环境诱导肺泡上皮细胞内质网应激促进DAMP-EV分泌加速机械通气相关性肺纤维化的机制国家自然科学基金面上项目 2022-01~2025-12 55万元  课题负责人
    SHDC12020122免疫细胞导向的临床外表型指导Sepsis患者治疗的应用上海市科委 2021-07~2024-12 57万元  课题负责人
    PY11200-01基于M1/M2/Mreg 的Sepsis临床分型体系的炎性免疫调控治疗对患者预后的影响上海交通大学医学院附属仁济医院 2021-07~2024-12 10万元  课题负责人
    GWV-3.1上海市感染(传染)病临床诊治中心及其网络体系建设上海市科委 2020-07~2022-12 121万元  课题负责人
    YG2019ZDB04使用光声显微成像系统定量监测微循环状态早期识别脓毒症患者的价值研究上海交通大学 2019-01~2022-12 30万元  课题负责人
    81870052机械牵张微环境诱导肺成纤维细胞代谢重编程致糖代谢态稳态失衡:机械通气促进脓毒症相关性肺纤维化的机制研究国家自然科学基金面上项目 2019-01~2022-12 57万元  课题负责人
    18411951100脓毒症患者病原体早期识别及免疫状态评估的临床观察性研究上海市科委 2018-07~2021-06 50万元  课题负责人
    2016ZB0206-01卫计委重要薄弱学科-急诊与危重病学上海市卫生局 2017-01~2020-01 25万元  课题负责人
    81670057 Thy-1表达缺失诱导整合素αvβ3变构及活化:脂多糖抑制肺成纤维细胞自噬的机制国家自然科学基金面上项目 2017-01~2020-12 57万元  课题负责人
    15411950405DCD供肝功能预测指标的建立及供肝保护技术的评价上海市科委医学和农业领域科技支撑项目 2015-07~2018-09 20万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Han Zhong#, Ming-Li Zhu#, Yue-Tian Yu#, Wen Li, Shun-Peng Xing, Xian-Yuan Zhao, Wei-Jun Wang, Zhi-Chun Gu*,  Management of Bivalirudin Anticoagulation Therapy for Extracorporeal Membrane Oxygenation in Heparin-Induced Thrombocytopenia: A Case Report and a Systematic Review.  Front Pharmacol.  2020  11:565013. 
    Hu X#, Xu Q#, Wan H, Hu Y, Xing S, Yang H,, He Z*  PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis.  Lab Invest.  2020  100(6):801-811. 
    Xiao Zhou#, Keji Zhang, Zhengyu He, Yuxiao Deng*,  Downregulated miR-150 in bone marrow mesenchymal stem cells attenuates the apoptosis of LPS-stimulated RAW264.7 via MTCH2-dependent mitochondria transfer.  Biochem Biophys Res Commun.  2020  4;526(3):560-567. 
    Jiangchen Peng# ,Yujie Li# ,Jiemin Wang ,Mingli Zhu* ,  Incidence of chronic kidney disease after orthotopic liver transplantation in a Chinese cohort.  Clin Exp Nephrol  2020  24(9):806-812 
    Wan H#, Xie T#, Xu Q, Hu X, Xing S, Yang H,, He Z*.  Thy-1 depletion and integrin β3 upregulation-mediated PI3K-Akt-mTOR pathway activation inhibits lung fibroblast autophagy in lipopolysaccharide-induced pulmonary fibrosis.  Lab Invest.  2019  99(11):1636-1649. 
    Xie T#, Xu Q#, Wan H, Xing S, Shang C,, He Z*.  Lipopolysaccharide promotes lung fibroblast proliferation through autophagy inhibition via activation of the PI3K-Akt-mTOR pathway.  Lab Invest.  2019  99(5):625-633. 
    Zhao X#, Qi H#, Zhou J, Xu S,  Treatment With Recombinant Interleukin-15 (IL-15) Increases the Number of T Cells and Natural Killer (NK) Cells and Levels of Interferon-γ (IFN-γ) in a Rat Model of Sepsis.  Med Sci Monit.  2019  25:4450-4456. 
    Yuetian Yu#, Chunyan Liu#, Zhongheng Zhang, Hui Shen, Yujie Li, Liangjing Lu.Yuan Gao*.  Bronchoalveolar lavage fluid dilution in ICU patients: what we should know and what we should do  Crit Care  2019  24;23(1) 
    Zhao X#, Qi H#, Zhou J, Xu S,  P27 Protects Cardiomyocytes from Sepsis via Activation of Autophagy and Inhibition of Apoptosis.  Med Sci Monit.  2018  24:8565-8576. 
    Yu Y#, Shen H, Zhu C, Guo R,, Lu L*.  Infections Caused by Extended-Spectrum β-Lactamase Producing Escherichia Coli in Systemic Lupus Erythematosus Patients: Prevalence, Risk Factors, and Predictive Model.  Biomed Res Int.  2018  2018:8296720. 
    Yu Y#, Zhu C#, Liu C,  Amphotericin B nebulisation for invasive pulmonary aspergillosis prophylaxis: the conflict of ideality and reality.  Int J Antimicrob Agents.  2017  49(2): 263-264.  
    Yu Y#, Zhu C#, Liu C*,  Effect of Prior Atorvastatin Treatment on the Frequency of Hospital Acquired Pneumonia and Evolution of Biomarkers in Patients with Acute Ischemic Stroke: A Multicenter Prospective Study.  Biomed Res Int.  2017  2017:5642704. 
    Yu Y#, Zhu C#, Liu C,  How to remove the grey area between ventilator-associated pneumonia and ventilator-associated tracheobronchitis?  Crit Care.  2017  21:165. 
    Xing S#, Wen D#, Zhu L, Wang J, Li Z, Yang L*,  Magnet guidance reduces misplacement of subclavian vein catheter in internal jugular vein.  Intensive Care Med.  2017  43(5):711-712. 
    Yu Y#, Zhu C#, Qian X,, Zhang Z*.  Adult patient with pulmonary agenesis: focusing on one-lung ventilation during general anesthesia.  J Thorac Dis.  2016  8(1):E124-129. 
    Yu Y#, Zhu C#,  Bronchoalveolar lavage fluid galactomannan as a diagnostic biomarker for IPA: still a long way to go.  Crit Care.  2016  20:280. 
    Xing S, Nie F, Xu Q, Deng Y, Li W, Yang Z, Zhao X, Zhu P, Wang X,, He Z  HDAC is essential for epigenetic regulation of Thy-1 gene expression during LPS/TLR4-mediated proliferation of lung fibroblasts.  Lab Invest  2015  95(10):1105-1116 
    Li W, Xu Q, Deng Y, Yang Z, Xing S, Zhao X, Zhu P, Wang X, He Z,  High-mobility group box 1 accelerates lipopolysaccharide-induced lung fibroblast proliferation in vitro: involvement of the NF-kappaB signaling pathway.  Lab Invest  2015  95(6):635-647 
    He Z, Deng Y, Li W, Chen Y, Xing S, Zhao X, Ding J,, Wang X  Overexpression of PTEN suppresses lipopolysaccharide-induced lung fibroblast proliferation, differentiation and collagen secretion through inhibition of the PI3-K-Akt-GSK3beta pathway.  Cell Biosci  2014  4(1):2-2 
    He ZY, Wang XR, Deng YX, Li W, Chen YM, Xing SP, Zhao XY, Ding J,  Epigenetic regulation of Thy-1 gene expression by histone modification is involved in lipopolysaccharide-induced lung fibroblast proliferation  J Cell Mol Med  2013  17(1):160-167