• 基本信息
    导师姓名: 张雷 学科代码: 100302
    性别: 学科名称: 口腔临床医学
    培养单位: 口腔医学院 三级学科
    导师类型: 硕士生导师 专业领域名称: 口腔医学 专业学位
    联系方式: 上海市制造局路639号1号楼15楼 专业领域代码: 105200
    邮编: 200011 邮箱地址: oral66@126.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市医学会医学美学与美容专委会 青年委员
    中国整形美容协会精准与数字医学分会颅颌面整复专委会 常务委员
    中华口腔医学会口腔颌面创伤及正颌专委会 委员、学术秘书
    中国整形美容协会精准与数字医学分会 理事
    上海市口腔医学会口腔颌面放射专委会 常务委员
    上海市口腔医学会口腔颌面外科专委会 委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    YBKB202110偏突颌畸形的生物样本库建立上海交通大学医学院附属第九人民医院生物样本库项目 2021-09~2024-08 25万元  课题负责人
    21140900103自发性早衰老小鼠的骨与关节衰老相关表型分析与骨衰老的ceRNA机制研究上海市科委实验动物研究领域项目 2021-06~2024-06 30万元  课题负责人
    20ZR1432200MicroRNA-130b-YAP轴在增龄性颌骨再生中的作用及机制研究上海市自然科学基金 2020-07~2023-06 20万元  课题负责人
    JYLJ201823浓缩型生长因子影响PAOO术后牙周组织增量的前瞻性随机对照研究上海交通大学医学院附属第九人民医院临床研究助推计划 2018-07~2021-06 20万元  课题负责人
    31571018基于人源性组织异种移植瘤(PDTX)模型的新型miRNA纳米载体构建及其治疗效应研究国家自然科学基金 2016-01~2019-12 70万元  课题参与人
    81271114GDF15过表达促进骨髓间充质干细胞成血管和成骨作用的分子机制与骨再生研究国家自然科学基金 2013-01~2016-12 70万元  课题参与人
    81202133WNT信号通路拮抗因子甲基化异常作为口腔黏膜下纤维性变癌变早期检测分子标志物的研究国家自然科学基金 2013-01~2015-12 20万元  课题参与人
    81271122Dlx2基因过表达通过调控TGF-β信号通路参与第一鳃弓畸形发生国家自然科学基金 2013-01~2016-12 70万元  课题参与人
    81202131酪氨酸激酶类受体c-Met调控口腔鳞癌干细胞特性的实验研究国家自然科学基金 2013-01~2015-12 20万元  课题参与人
    81202132人乳头状瘤病毒通过上调IL-13表达影响TGF-β/Smad信号通路促口咽癌发生的机制研国家自然科学基金 2013-01~2015-12 20万元  课题参与人
    XYQ2011029Yes相关蛋白对AP-1家族基因的调控及其在口腔上皮细胞癌变中的作用机制研究上海市卫生系统优秀青年人才培养计划 2012-01~2014-12 30万元  课题负责人
    jdy10040YAP基因通过调控Fra-1影响口腔粘膜癌变的机制研究上海高校选拔培养优秀青年教师科研专项基金 2011-01~2012-12 3万元  课题负责人
    81001206YAP基因通过调控Wnt/β-catenin信号通路影响口腔上皮细胞癌变的机制研究国家自然科学基金 2011-01~2013-12 20万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Cao J, Shen S, Liu Z, Wu J, Shi J,, Zhu M*, Wang X  Reconstruction of Dentomaxillofacial Deformity Secondary to Mandibular Defect Using Concomitant Orthognathic Surgery and Fibula Free Flap.  Plast Reconstr Surg.  2023  151(1):179-183 
    Jiawen Si, Chenglong Zhang, Ming Tian, Tengfei Jiang,, Hongbo Yu, Jun Shi and Xudong Wang.  Intraoral Condylectomy with 3D-Printed Cutting Guide versus with Surgical Navigation An Accuracy and Effectiveness Comparison  Journal of Clinical Medicine.  2023  12(11):3816 
    Lei Qi, Weiwen Ge, Cancan Pan, Weidong Jiang, Dan Lin *,  Compromised osteogenic effect of exosomes internalized by senescent bone marrow stem cells via endocytoses involving clathrin, macropinocytosis and caveolae.  Front Bioeng Biotechnol  2023  10:1090914 
    Yitong Wang, Jinjie Cui, Jiajie Chen, Jiayu Wan, Yakun Liang, Ming Qi, Xudong Wang*,, Kaili Lin  Novel bone tumor cell targeting nanosystem for chemo-photothermal therapy of malignant bone tumors.   Chemical Engineering Journal  2022  136905 
    Qi L, Ge W, Cao N, Wang S, Qian Y, Wang X,  Effects of autologous concentrated growth factor on gingival thickness in periodontal accelerated osteogenic orthodontics: a 6-month randomized controlled trial.   BMC Oral Health  2021  21(1):604 
    Biao Li , Hongpu Wei , Tengfei Jiang , Yifeng Qian, Tianjia Zhang, Hongbo Yu,, Xudong Wang  Randomized Clinical Trial of the Accuracy of Patient-Specific Implants versus CAD/CAM Splints in Orthognathic Surgery.  Plast Reconstr Surg  2021  148(5):1101-1110 
    Qi L, Cao N, Ge W, Jiang T, Fan L,  A new method for individual condylar osteotomy and repositioning guides used in patients with severe deformity secondary to condylar osteochondroma.   Orphanet J Rare Dis  2021  16(1):59  
    Lei Qi, Lu Liu,Yue Hu, Jie Li, Jiayi Li, Ningning Cao, Fangxing Zhu, Chaoji Shi*,  Concentrated Growth Factor Promotes Gingival Regeneration Through the Akt/Wnt/β-Catenin and YAP Signaling Pathways.  Artif Cells Nanomed Biotechnology  2020  48(1):920-932 
    Lei Qi, Yifeng Qian, Fangxing Zhu, Ningning Cao, Hai xia Lu, Lei Zhang  Association between periodontal disease and tooth loss and mortality in an elderly Chinese population  Aging Clin Exp Res  2020  32(11):2375-2382 
    Qi L, Shi CJ, Li J, Xu S, Han Y, Li J,  Yes-associated protein promotes cell migration via activating Wiskott-Aldrich syndrome protein family member 1 in oral squamous cell carcinoma.   J Oral Pathol Med  2019  48(4):290-298 
    , Liu ZX, Li B, Yu HB, Shen SG, Wang XD  Evaluation of computer-assisted mandibular reconstruction with vascularized fibular flap compared to conventional surgery.   Oral Surg Oral Med Oral Pathol Oral Radiol.  2016  121(2):139-48 
    Dong C, Ye DX, Zhang WB, Pan HY, Zhang ZY,  Overexpression of c-fos promotes cell invasion and migration via CD44 pathway in oral squamous cell carcinoma  J Oral Pathol Med  2015  44(5):353-60 
    Dong C, Wei KJ, Zhang WB, Sun H, Pan HY,  LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral squamous cell carcinoma.   J Oral Pathol Med  2015  44(6):475-81 
    , Shen S, Yu H, Shen SG, Wang X.  Computer-Aided Design and Computer-Aided Manufacturing Hydroxyapatite/Epoxide Acrylate Maleic Compound Construction for Craniomaxillofacial Bone Defects.  J Craniofac Surg  2015  26(5):1477-81 
    Sun S, Liu S, Duan SZ,, Zhou H, Hu Y, Zhou X, Shi C, Zhou R, Zhang Z.  Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas.   Cancer Res.  2014  74(24):7546-59 
    , Hao Sun, Hong-bo Yu, Hao Yuan, Guo-fang Shen, Xu-dong Wang.  Computer-Assisted Orthognathic Surgery Combined With Fibular Osteomyocutaneous Flap Reconstruction to Correct Facial Asymmetry and Maxillary Defects Secondary to Maxillectomy in Childhood.  The Journal of Craniofacial Surgery   2013  24(3):886-889 
    Li B,, Zhao Z, Shen G, Wang X.   Minimally invasive endoscopic resection of benign tumours of the accessory parotid gland: an updated approach.   Br J Oral Maxillofac Surg  2013  51(4):342-6 
    Dai Jiewen, Wang Jia, Lu Jingting, Zou Duohong, Sun Hao, Dong Yuefu, Yu Hongbo,, Yang Tong, Zhang Xiuli, Wang Xudong, Shen Guofang.  The effect of co-culturing costal chondrocytes and dental pulp stem cells combined with exogenous FGF9 protein on chondrogenesis and ossification in engineered cartilage.  Biomaterials  2012  33(31):7699-7711 
    , Ye DX, Pan HY, Wei KJ, Wang LZ, Wang XD, Shen GF, Zhang ZY  Yes-associated protein promotes cell proliferation by activating Fos Related Activator-1 in oral squamous cell carcinoma.  Oral Oncol.   2011  47(8):693-7 
    , Pan HY, Zhong LP, Wei KJ, Yang X, Li J,zhang ZY.  Fos Related Activator-1 Is Overexpressed in oral Squamous Cell Carcinoma and Associated with Tumor Lymph Node Metastasis.  J Oral Pathol Med  2010  39(6):470-6 
    , Yang X, Pan HY, Zhou XJ, Li J, Chen WT,zhang ZY.  Expression of growth differentiation factor 15 is positively correlated with histopathological malignant grade and in vitro cell proliferation in oral squamous cell carcinoma.  Oral Oncology  2009  45(7):627-632 
    , Yang X, Zhong LP, Zhou XJ, Pan HY, Wei KJ, Zhang ZY  Decreased expression of Annexin A1 correlates with pathologic differentiation grade in oral squamous cell carcinoma.  J Oral Pathol Med.  2009  38(4):362-370