• 基本信息
    导师姓名： 余健秀 学科代码： 100100
    性别： 男 学科名称： 基础医学
    培养单位： 基础医学院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： Email Address: Jianxiu.Yu@gmail.com; Jianxiu.Yu@shsmu.edu.cn; 电话：021-54660870 专业领域代码：
    邮编： 200025 邮箱地址： Jianxiu.Yu@Gmail.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    担任中国抗癌协会肿瘤标志专业委员会“非编码与肿瘤研究”专家委员会副组长；担任国际著名杂志杂志Nature, Cancer Research, Oncogene, CMLS, FEBS J, JBC等审稿专家
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81630075PTEN在DNA损伤修复中介导组蛋白H2A/H3修饰调控前列腺癌发生发展国家自然科学基金重点项目 2017-01~2021-12 275万元  课题负责人
    31671345Ago2乙酰化在miRNA途径中的功能与机制国家自然科学基金面上项目 2017-01~2020-12 65万元  课题负责人
    81472571Shp2类泛素（SUMO）化修饰促进ERK信号通路激活而加速肝癌发生发展国家自然科学基金面上项目 2015-01~2018-12 74万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Zhao X#, Wang Y#, He J#, Deng R, Huang X, Guo Y, Li L, Xie R*,  LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells   Mol Carcinog.   2020  59(10):1174-1187 
    Dou J#, Zhang H#, Chen R#, Shu Z, Yuan H, Zhao X, Wang Y, Huang J, Zhou A*,  SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells  Mol Oncol  2020  14(9):2288-2312 
    Liu T#, Zhang H#, Fang J, Yang Z, Chen R, Wang Y, Zhao X, Ge S,, Huang J*.   AGO2 phosphorylation by c-Src kinase promotes tumorigenesis  Neoplasia  2020  22(3):129-141 
    Lin R, Zhan M, Yang L, Wang H, Shen H, Huang S, Huang X, Xu S, Zhang Z, Li W, Liu Q, Shi Y, Chen W,, Wang J*.  Deoxycholic Acid Modulates the Progression of Gallbladder Cancer Through N 6-methyladenosine-dependent microRNA Maturation  Oncogene  2020  39(26):4983-5000 
    Zhang H#, Wang Y#, Dou J#, Guo Y, He J, Li L, Liu X, Chen R, Deng R, Huang J, Xie R, Zhao X*,  Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis  Oncogene  2019  38(9):1410-1431 
    Cui N, Liu T, Guo Y, Dou J, Yang Q, Zhang H, Chen R, Wang Y, Zhao X,, Huang J*.   SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function  Neoplasia  2019  21(7):676-688. 
    Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X*,  SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function  Nucleic Acids Res  2018  46(10) 5195-5208. 
    Chen Q*, Deng R, Zhao X, Yuan H, Zhang H, Dou J, Chen R, Jin H, Wang Y, Huang J,  SUMOylation of EphB1 suppresses neuroblastoma tumorigenesis via inhibiting PKCγ activation.  Cellular Physiology and Biochemistry  2018  45:2283-2292. 
    Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G,, Zhang J*.  Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.   Nature Chem Biol  2017  13(9):994-1001 
    Wang J, Deng R, Cui N, Zhang H, Liu T, Dou J, Zhao X, Chen R, Wang Y,, Huang J*  Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation.   Neoplasia  2017  19(12):961-971 
    Zhao X, Deng R, Wang Y, Zhang H, Dou J, Li L, Du Y, Chen R, Cheng J,  Twist1/Dnmt3a and miR186 establish a regulatory circuit that controls inflammation-associated prostate cancer progression.  Oncogenesis  2017  6(4): e315.  
    Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, Wang Y, Xu M, Jiang B*,  SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis  Mol Cancer  2017  16(1):157 
    Zhu C, Chen C, Chen R, Deng R, Zhao X, Zhang H, Duo J, Chen Q, Jin H, Wang Y, Huang J, Xu M,  K259-SUMOylation of DGCR8 promoted by p14ARF exerts a tumor-suppressive function  J Mol Cell Biol  2016  8(5),456–458 
    Zhao X, Wang Y, Deng R, Zhang H, Dou J, Yuan H, Hou G, Du Y, Chen Q,  miR186 suppresses prostate cancer progression by targeting Twist1  Oncotarget  2016  7(22): 33136-51 
    Xu M, Zhu C, Zhao X, Chen C, Zhang H, Yuan H, Deng R, Dou J, Wang Y, Huang J, Chen Q, Jiang B,  Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors  Oncotarget  2015  6(2): 979-94 
    Chen Q, Zhao X, Zhang H, Yuan H, Zhu M, Sun Q, Lai X, Wang Y, Huang J, Yan J,  MiR-130b suppresses prostate cancer metastasis through down-regulation of MMP2  Molecular Carcinogenesis  2015  54(11):1292-300 
    Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y,  SUMOylation at K707 of DGCR8 controls direct function of primary microRNA  Nucleic Acids Res.   2015  43(16):7945-60 
    Deng R, Zhao X, Qu Y, Chen C, Zhu C, Zhang H, Yuan H, Jin H, Liu X, Wang Y, Chen Q, Huang J,  Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development  Oncotarget  2015  6(11):9355-69 
    Chen C, Zhu C, Huang J, Zhao X, Deng R, Zhang H, Dou J, Chen Q, Xu M, Yuan H, Wang Y,  SUMOylation of TARBP2 regulates miRNA/siRNA efficiency  Nature Communications  2015  6:9899 
    Lai X, Chen Q, Zhu C, Deng R, Zhao X, Chen C, Wang Y,, Huang J*  Regulation of RPTPα-c-Src signalling pathway by miR-218.  FEBS J.  2015  282(14):2722-34 
    Lu S#, Deng R#, Jiang H#, Song H#, Li S, Shen Q, Huang W, Nussinov R,, Zhang J*   The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation.   Structure  2015  23(9):1725-34 
    Qu Y, Chen Q, Lai X, Zhu C, Chen C, Zhao X, Deng R, Xu M, Yuan H, Wang Y,, Huang J*  SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1   Mol Cancer  2014  13(1):95 
    Sun Q, Zhao X, Liu X, Wang Y, Huang J, Jiang B, Chen Q,  miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1.   Prostate  2014  74(16):1613-21 
    Zhu M, Chen Q, Liu X, Sun Q, Zhao X, Deng R, Wang Y, Huang J, Xu M, Yan J,  lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI  FEBS J.   2014  281:3766-3775 
    Liu X, Chen Q, Yan J, Wang Y, Zhu C, Chen C, Zhao X, Xu M, Sun Q, Deng R, Zhang H, Qu Y, Huang J, Jiang B,  MiRNA-296-3p-ICAM-1 axis promotes metastasis of prostate cancer by possible enhancing survival of natural killer cell-resistant circulating tumour cells.  Cell Death Dis.  2013  21;4:e928 
    , Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS*   Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1 and SH2-tyrosine phosphatase Shp2.  J Biol Chem  2013  288(6):3823-30 
    Liu X, Wang Y, Sun Q, Yan J, Huang J, Zhu S,  Identification of microRNA transcriptome involved in human natural killer cell activation  Immunol Lett  2012  143(2):208-17 
    , Zhang D, Liu J, Li J, Yu Y, Wu XR, Huang C  RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and its Inhibiting Cancer Cell Motility  J Biol Chem  2012  287:13752-60 
    Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G,  SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane  Nature Communications  2012  3:911-925 
    , Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E*, Mustelin T.  PTEN regulation by Akt-EGR1-ARF-PTEN axis  EMBO J  2009  28:21-33 
    , Baron V, Mercola D, Mustelin T, Adamson ED  A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells  Cell Death and Differentiation  2007  14:436-446 
    , de Belle I, Liang H, Adamson ED  Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses  Molecular Cell  2004  15: 83-94