- 基本信息
|
导师姓名：
|
许峰
|
学科代码：
|
100201
|
|
|
性别：
|
男
|
学科名称：
|
内科学
|
|
培养单位：
|
附属第六人民医院
|
三级学科
|
血液病
|
|
导师类型：
|
硕士生导师
|
专业领域名称：
|
内科学 专业学位
|
|
联系方式：
|
xvfeng3619@163.com
|
专业领域代码：
|
105101
|
|
邮编：
|
200233
|
邮箱地址：
|
xvfeng3619@163.com
|
- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 81770122 | 骨髓微环境SLIT2-ROBO1信号失活促进MDS细胞恶性增殖的作用机制及靶向干预研究 | 国家自然科学基金委面上项目 |
2018-01~2021-12
|
55万元
| 课题负责人 |
| 201640267 | MYCN在骨髓增生异常综合征白血病转化中的分子机制研究 | 上海市卫计委面上项目 |
2017-01~2019-12
|
5万元
| 课题负责人 |
| 81300389 | miR-10a通过RYBP调控MDS克隆细胞凋亡抵抗的分子机制 | 国家自然科学基金委青年项目 |
2014-01~2016-12
|
23万元
| 课题负责人 |
- 学术论文
|
Liu L,, Chang CK, He Q, Wu LY, Zhang Z, Li X
|
MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21
|
Cell Death Dis
|
2017
|
8(10):e3126
|
|
, Wu LY, He Q, Wu D, Zhang Z, Song LX, Zhao YS, Su JY, Zhou LY, Guo J, Chang CK, Li X
|
Exploration of the role of gene mutations in myelodysplastic syndromes through a sequencing design involving a small number of target genes
|
Sci Rep
|
2017
|
7:43113
|
|
, Zhu Y, He Q, Wu LY, Zhang Z, Shi WH, Liu L, Chang CK, Li X
|
Identification of microRNA-regulated pathways using an integration of microRNA-mRNA microarray and bioinformatics analysis in CD34+ cells of myelodysplastic syndromes
|
Sci Rep
|
2016
|
6:32232
|
|
, Liu L, Chang CK, He Q, Wu LY, Zhang Z, Shi WH, Guo J, Zhu Y, Zhao YS, Gu SC, Fei CM, Li X.
|
Genomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome
|
Oncotarget
|
2016
|
7(7):8119-30
|
|
, Wu LY, Chang CK, He Q, Zhang Z, Liu L, Shi WH, Guo J, Zhu Y, Zhao YS, Gu SC, Fei CM, Wu D, Zhou LY, Su JY, Song LX, Xiao C, Li X.
|
Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes
|
Nat Commun
|
2015
|
6:8806
|
|
, He Q, Li X, Chang CK, Wu LY, Zhang Z, Liu L, Shi WH, Zhu Y, Zhao YS, Gu SC, Fei CM, Guo J, Wu D, Zhou L
|
Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome
|
Sci Rep
|
2014
|
4:7310
|
|
, Li X, Chang CK, Guo J, Wu LY, He Q, Zhang Z, Zhu Y, Gu SC, Shi WH, Song LX, Su JY, Zhou LY, Zhang X, Wu D
|
Establishment and validation of an updated diagnostic FCM scoring system based on pooled immunophenotyping in CD34+ blasts and its clinical significance for myelodysplastic syndromes
|
PLoS One
|
2014
|
9(2):e88706
|
|
Li X, Xiao ZJ, Chang CK,, Wu LY, He Q, Xu ZF, Song LX, Zhang Z, Zhou LY, Su JY, Zhang X, Guo J.
|
Distinct clinical and experimental characteristics in the patients younger than 60 years old with myelodysplastic syndromes
|
PloS one
|
2013
|
8(2):e57392
|
|
, Guo J, Wu LY, He Q, Zhang Z, Chang CK, Li X
|
Diagnostic application and clinical significance of FCM progress scoring system based on immunophenotyping in CD34+ blasts in myelodysplastic syndromes
|
Cytometry B Clin Cytom
|
2013
|
84(4):267-78
|
|
Li X,, Karoopongse E, Marcondes AM, Lee K, Kowdley KV, Miao CH, Trobridge GD, Campbell JS, Deeg HJ
|
Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin
|
Biol Blood Marrow Transplant
|
2013
|
19(8):1210-9
|
|
, Deeg HJ
|
Current status of allogeneic hematopoietic cell transplantation for MDS
|
Curr Pharm Des
|
2012
|
18(22):3215-21
|
|
, Yang R, Wu L, He Q, Zhang Z, Zhang Q, Yang Y, Guo J, Chang C, Li X
|
Overexpression of BMI1 confers clonal cells resistance to apoptosis and contributes to adverse prognosis in myelodysplastic syndrome
|
Cancer Lett
|
2012
|
317(1):33-40
|
|
, Li X.
|
The role of histone methyltransferase EZH2 in myelodysplastic syndromes
|
Expert Rev Hematol
|
2012
|
5(2):177-85
|
|
, Li X, Wu L, Zhang Q, Yang R, Yang Y, Zhang Z, He Q, Chang C
|
Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring
|
Ann Hematol
|
2011
|
90(6):643-53
|
|
, Li X, Wu L, He Q, Zhang Z, Chang C
|
Flow cytometric scoring system (FCMSS) assisted diagnosis of myelodysplastic syndromes (MDS) and the biological significance of FCMSS-based immunophenotypes
|
Br J Haematol
|
2010
|
149(4):587-97
|
|
,李晓
|
骨髓增生异常综合征的表观遗传学改变
|
中国实验血液学杂志
|
2010
|
18(2):531-5
|
|
,李晓
|
骨髓增生异常综合征表观遗传学治疗进展
|
白血病淋巴瘤杂志
|
2009
|
18(11):690-693
|
|
, Li X, Chang C, He Q, Zhang Z, Zhang Q, Wu L
|
A delayed yet durable response to very short lenalidomide therapy and unexpected clone redistribution in a case of myelodysplastic syndrome with del(5q) and del(20q)
|
Leuk Res
|
2009
|
33(11):e199-202.
|
|