• 基本信息
    导师姓名： 胡承 学科代码： 100201
    性别： 男 学科名称： 内科学
    培养单位： 附属第六人民医院 三级学科 内分泌与代谢病
    导师类型： 博士生导师 专业领域名称：
    联系方式： 专业领域代码：
    邮编： 200233 邮箱地址： alfredhc@sjtu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    Diabetes Metabolism Research Review编委
    中华医学会医学遗传学分会青年委员
    《中华糖尿病杂志》编委
    《中华内分泌代谢杂志》编委
    Plos One编委
    亚洲糖尿病学会AASD学术委员会委员
    中华医学会糖尿病学分会青年委员会副主任委员
    中国医药生物技术协会基因检测技术分会 青委副主委
    《上海交通大学学报（医学版）》编委
    《中国糖尿病杂志》编委
    中华医学会糖尿病学分会转化医学学组 副组长
    上海医学会糖尿病专科委员会委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    823250102型糖尿病遗传与代谢调控国家自然科学基金委员会杰出青年基金 2024-01~2028-12 400万元  课题负责人
    2023ZKZD17GPSM1介导的下丘脑星形胶质细胞与神经元代谢偶联调控机体血糖稳态的机制研究上海市教委重大项目 2023-01~2027-12 300万元  课题负责人
    82270894 下丘脑血管内皮铁稳态在糖脂代谢中作用及机制的研究国家自然科学基金面上项目 2023-01~2026-12 58万元  课题负责人
    21SG11糖尿病新致病基因GPSM1参与脂肪胰岛素抵抗致2型糖尿病的机制研究 上海市曙光计划 2021-09~2024-09 15万元  课题负责人
    YG2021ZD20疑难代谢性疾病精准诊断新技术的建立与应用上海交通大学医工交叉重点项目 2021-01~2023-12 100万元  课题负责人
    20XD1433300中国人糖尿病精准预警、诊断及治疗芯片的研发及应用上海市2020年度“科技创新行动计划”技术带头人项目 2020-10~2023-09 40万元  课题负责人
    81974118IL-22调控FXR影响肝脏胆汁酸及糖脂代谢改善2型糖尿病机制研究国家自然科学基金面上项目 2020-01~2023-12 59万元  课题负责人
    NA青少年的成人起病型糖尿病的遗传学机制上海交通大学-香港中文大学联合科研基金 2019-01~2019-12 25万元  课题负责人
    2017BR008上海市卫生计生系统优秀学科带头人上海市卫健委 2017-07~2020-06 45万元  课题负责人
    91649112CDKN2A基因在胰岛β细胞衰老致2型糖尿病的机制及其致病变异定位国家自然科学基金重大研究计划 2017-01~2019-12 72万元  课题负责人
    2016YFC1304902遗传因素对代谢和胰岛B细胞功能动态变化影响的研究国家重点研发计划 2016-09~2020-12 117万元  课题负责人
    NA长江学者青年学者教育部长江学者奖励计划 2016-03~2019-02 0万元  课题负责人
    81570713中国人2型糖尿病易感位点7q32中致病位点的定位及其机制研究国家自然科学基金面上项目 2016-01~2019-12 69.6万元  课题负责人
    无2型糖尿病及并发症易感基因的发现及风险预测模型的构建上海交通大学医学院高峰高原计划—“临床专职科研队伍” 2016-01~2018-12 100万元  课题负责人
    YG2014MS18基于遗传和临床数据的中国人2型糖尿病预测模型的构建上海交通大学医工交叉项目 2015-01~2016-12 15万元  课题负责人
    Null上海交通大学晨星学者A类上海交通大学 2014-09~2017-08 15万元  课题负责人
    无青年拔尖人才支持计划中央组织部 2014-01~2016-12 240万元  课题负责人
    81322010糖尿病遗传机制与个体化治疗国家自然科学基金优秀青年基金 2014-01~2016-12 100万元  课题负责人
    2012041中国人2型糖尿病的遗传机制研究上海市人才发展资金 2013-01~2015-12 24万元  课题负责人
    12QH1401700肥胖相关基因与中国成人体脂分布及腹型肥胖的关系上海市科技启明星跟踪计划 2012-09~2014-08 20万元  课题负责人
    81170735利用全外显子捕获测序技术寻找中国人2型糖尿病的易感基因国家自然基金委,面上项目 2012-01~2015-12 58万元  课题负责人
    XYQ2011041胰岛功能相关基因与糖尿病微血管病变的关系上海市卫生系统优秀青年医学人才培养计划 2011-07~2013-06 60万元  课题负责人
    09CG07GCK、GCKR和MTNR1B基因与中国人空腹血糖及2型糖尿病的关系上海市晨光计划（A类） 2009-09~2011-08 6万元  课题负责人
    09QA1404400细胞增殖与凋亡基因常见变异与2型糖尿病的关联研究上海市青年科技启明星计划（A类） 2009-07~2011-06 15万元  课题负责人
    30800617中国人2型糖尿病全基因组关联研究中发现易感位点的大样本关联研究国家自然基金委,面上项目 2009-01~2011-12 20万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Liu C, Meng M, Xu B, Xu Y, Li G, Cao Y, Wang D, Qiu J, Yu J, Xu L, Ma X,  Fibroblast growth factor 6 promotes adipocyte progenitor cell proliferation for adipose tissue homeostasis  Diabetes  2023  72(4): 467-482 
    Lai S, Yan D, Xu J, Yu X, Guo J, Fang X, Tang M, Zhang R, Zhang H, Jia W, Luo M,  Genetic variants in epoxyeicosatrienoic acid processing and degradation pathways are associated with gestational diabetes mellitus  Nutr J  2023  22(1):31 
    Yu H, Yu H, Zhang R, Peng D, Yan D, Gu Y, Bao Y, Jia W, Zhang H,  Targeted gene panel sequencing provides advantages over whole-exome sequencing as a first-tier test for diagnosing obesity and diabetes mellitus  J Mol Cell Biol  2023  online 
    Guo M, Zhang J, Ma Y, Zhu Z, Zuo H, Yao J, Wu X, Wang D, Yu J, Meng M, Liu C, Zhang Y, Chen J, Lu J, Ding S,, Ma X, Xu L  AAV-Mediated nuclear localized PGC1α4 delivery in muscle ameliorates sarcopenia and aging-associated metabolic dysfunctions  Aging Cell  2023  e13961 
    Zhang Y, Zhu Y, Wang J, Jin L, Guo M, Chen L, Zhang L, Li Y, Wan B, Zhang R, Jia W,  Neuregulin4 acts on hypothalamic ErBb4 to excite oxytocin neurons and preserve metabolic homeostasis  Adv Sci  2023  10: 2204824 
    Guo M, Yao J, Li J, Zhang J, Wang D, Zuo H, Zhang Y, Xu B, Zhong Y, Shen F, Lu J, Ding S,, Xu L, Xiao J, Ma X  Irisin ameliorates age-associated sarcopenia and metabolic dysfunction  J Cachexia Sarcopenia Muscle  2023  14(1):391-405 
    Li Y, Wang D, Ping X, Zhang Y, Zhang T, Wang L, Jin L, Zhao W, Guo M, Shen F, Meng M, Chen X, Zheng Y, Wang J, Li D, Zhang Q,, Xu L, Ma X.  Local hyperthermia therapy induces browning of white fat and treats obesity  Cell  2022  185(6):949-966.e19. 
    Yin H, Yuan F, Jiao F, Niu Y, Jiang X, Deng J, Guo Y, Chen S, Zhai Q,, Li Y, Guo F  Intermittent leucine deprivation produces long-lasting improvement in insulin sensitivity by increasing hepatic Gcn2 expression  Diabetes  2022  71(2):206-218 
    Wang S, Deng Z, Zhang H, Zhang R, Yan D, Zheng X, Jia W,  The effect of haptoglobin genotype on the association of asymmetric dimethylarginine and DDAH 1 polymorphism with diabetic macroangiopathy  Cardiovascular Diabetology  2022  21:265 
    Xu J, Jin L, Chen J, Zhang R, Zhang H, Li Y, Peng D, Gu Y, Wheeler M,  Common variants in genes involved in islet amyloid polypeptide (IAPP) processing and the degradation pathway are associated with T2DM risk: a Chinese population study  Diabetes Res Clin Prac  2022  109235 
    Fang X, Jin L, Lu W, Lai S, Zhang R, Zhang H, Jiang F, Luo M,  Common single-nucleotide polymorphisms Combined with a Genetic Risk Score Provide New Insights Regarding the Etiology of Gestational Diabetes Mellitus  Diabetic Medicine  2022  39: e14885 
    Yan J, Zhang Y, Yu H, Zong Y, Wang D, Zheng J, Jin L, Yu X, Liu C, Zhang Y, Jiang F, Zhang R, Fang X, Xu T, Li M, Di J, Lu Y, Ma X, Zhang J, Jia W,  GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages  Nature Communications  2022  13: 7260 
    Bai N, Lu X, Jin L, Alimujiang M, Ma J, Hu F, Xu Y, Sun J, Xu J, Zhang R, Han J#,, Yang Y  CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue  Mol Metab  2022  63: 101531 
    Xu J, Jin L, Sun Y, Chen X, Zhou R, Zhang R, Gu Y,  12(S)- Hydroxyeicosatetraenoic acid is significantly increased in diabetic kidney disease and associated with renal function decline  Diabetes Metab Res Rev  2022  38(6): e3554 
    Li Y*, Jin L*, Jiang F, Yan J, Lu Y, Yang Q, Zhang Y, Zhang H, Yu HR, Zhang YM, He Z, Zhang R, Yang JJ,  Mutations of NRG4 contribute to the pathogenesis of non-alcoholic fatty liver disease and related metabolic disorders  Diabetes  2021  db210064 
    Li Y, Jin L, Yan J, Zhang H, Zhang R,  A causal relationship between CD28 and diabetic kidney disease in Chinese type 2 diabetes patients: a Mendelian randomization analysis  Mediators of Inflammation  2021  5521050 
    , Jia W  Multi-omics profiling: the way towards precision medicine in metabolic diseases  J Mol Cell Biol  2021  18;mjab051 
    Li Y, Jin L, Yan J, Huang Y, Zhang H, Zhang R,  Tsukushi and TSKU genotype in obesity and related metabolic disorders  J Endocrinol Invest  2021  doi: 10.1007/s40618-021-01572-x 
    Luo M, Tang M, Jiang F, Jia Y, Chin RKH, Liang W#,  Intrahepatic cholestasis of pregnancy and associated adverse maternal and fetal outcomes: a retrospective case-control study  Gastroenterology Research and Practice  2021  6641023 
    Lu W, Luo M, Fang X, Zhang R, Li S, Tang M, Yu X,  Discovery of metabolic biomarkers for gestational diabetes mellitus in a Chinese population  Nut Metab  2021  18(1):79 
    Li Y, Jin L, Yan J, Zhang H, Zhang R,  A causal relationship between CD28 and diabetic kidney disease in Chinese type 2 diabetes patients: a Mendelian randomization analysis  Mediators of Inflammation  2021  5521050 
    Xu B, Liu C, Zhang H, Zhang R, Tang M, Huang Y, Jin L, Xu L,, Jia W#  Skeletal muscle-targeted delivery of Fgf6 protects mice from diet-induced obesity and insulin resistance  JCI Insight  2021  6(19):e149969 
    Jie Xu , Nadeeja Wijesekara, Romario Regeenes, Dana Al Rijjal, Anthony L Piro, Youchen Song, Anne Wu, Alpana Bhattacharjee, Ying Liu, Lucy Marzban, Jonathan V Rocheleau, Paul E Fraser, Feihan F Dai,, Michael B Wheeler  Pancreatic β cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis  JCI Insight  2021  6(10):e143037. 
    Liu C, Zhou B, Meng M, Zhao W, Wang D, Yuan Y, Zheng Y, Qiu J, Li Y, Li G, Xiong X, Bian H, Zhang H, Wang H, Ma X,, Xu L, Lu Y.  FOXA3 induction under ER stress via XBP1s promotes PER1/SREBP1c transcription and contributes to non-alcoholic fatty liver disease  J Hepatol  2021  S0168-8278(21)00090-8 
    Huang Y, Zhang H, Wang C, Zhou J, Li Y,  DNA methylation suppresses liver Hamp expression in response to iron deficiency after bariatric surgery  Surg Obes Relat Dis  2020  16(1):109-118 
    Lu Y*, Wang E*, Chen Y*, Zhou B, Zhao J, Xiang L, Qian Y, Jiang J, Zhao L, Xiong X, Lu Z, Wu D, Liu B, Yan J, Zhang R, Zhang H,, Li X.#  Obesity-induced Excess of 17-hydroxyprogesterone Promotes Hyperglycemia Through Activation of Glucocorticoid Receptor  J Clin Invest  2020  130(7):3791-3804 
    Zong Y, Yan J, Jin L, Xu B, He Z, Zhang R,, Jia W#  Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population  Hereditas  2020  157:22 
    Huang Y, Jin L, Yu H, Jiang G, Tam C, Jiang S, Zheng C, Jiang F, Zhang R, Chan J, Ma R, Jia W,, Liu Z#  SNPs in PRKCA-HIF1A-GLUT1 are associated with diabetic kidney disease.  Eur J Clin Inv  2020  50:e13264 
    Wang C, Zhang H, Liu H, Bao Y, Di J#,  The genus Sutterella is a potential contributor of glucose metabolism improvement after Roux-en-Y gastric bypass surgery on type 2 diabetes  Diabetes Res Clin Prac  2020  162:108116 
    Tang M*, Luo M*, Lu W, Zhang R, Liang W, Gu J, Yu X, Zhang X,  Nerve growth factor is closely related to glucose metabolism, insulin sensitivity and insulin secretion: a case-control study in Chinese pregnant w  Nut Metab  2020  17: 98 
    Li Y, Zhang H, Tu Y, Wang C, Di J, Yu H, Zhang P, Bao Y, Jia W, Yang J,  Monogenic obesity mutations lead to less weight loss after bariatric surgery: a 6-year follow-up study  Obes Surg   2019  29(4):1169-1173 
    Wang J, Yan D, Zhao A, Jia W,, Zhang Z, Jia W  Discovery of potential biomarkers for osteoporosis using LC-MS/MS metabolomic methods  Osteoporosis Int  2019  30(7), 1491-1499 
    Tang M, Luo M, Lu W, Wang S, Zhang R, Liang W, Gu J, Yu X, Zhang X,  Serum growth differentiation factor 15 is associated with glucose metabolism in the third trimester in Chinese pregnant women  Diabetes Res Clin Pract  2019  156:107823 
    Zhang H, Chang Y, Zheng Q, Zhang R,, Jia W.  Altered intestinal microbiota associated with colorectal cancer.  Front Med  2019  13(4):461-470 
    , Jia W  Therapeutic medications against diabetes: What we have and what we expect  Adv Drug Delivery Rev  2019  139:3-15 
    Wang S, Wang J, Zhang R, Zhao A, Zheng X, Yan D, Jiang F, Jia W,, Jia W  Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach  Cardiovascular Diabetology   2019  18:8 
    Wang S, Zhang R, Wang T, Jiang F,, Jia W  Association of the genetic variant rs2000999 with haptoglobin and diabetic macrovascular diseases in Chinese patients with type 2 diabetes  J Diabetes Complications  2019  33(2):178-181 
    Yu W, Zhu H, Chen X, Gu X, Zhang X, Shen F, Jia W,  Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes  J Diabetes Res  2019  2019:9387358 
    Sun Y, Xu F, Yan D, Kahaer M, Zhang X, Guo Y,, Jia W, Luo L  Association between SLC2A9 genetic variants and risk of hyperuricemia in the Uygur population  Curr Med Sci  2019  39(2):243-249 
    Yu H, Wang T, Zhang R, Yan J, Jiang F, Li S, Jia W#,  Alcohol consumption and its interaction with genetic variants are strongly associated with the risk of type 2 diabetes: a prospective cohort study  Nutr Metab (Lond)  2019  16:64 
    Liu H, Zhang H, Wang X,, Zhang X#  Alterations of DNA methylation profile in proximal jejunum potentially contribute to the beneficial effects of gastric bypass in a diabetic rat model  Surg Obes Relat Dis  2019  15(8):1291-1298 
    He Z, Yang J, Zhang R, Li H, Wu L, Jiang F, Jia W,  Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population  J Dig Dis  2019  20(4):189-195 
    Huang Y, Huang Y, Zhang R, Jin L, Zhang H,  Serum haptoglobin levels are associated with renal function decline in type 2 diabetes mellitus patients in a Chinese Han population  Diabetes Res Clin Pract  2019  156:107865 
    He Z, Zhang R, Jiang F, Zhang H, Zhao A, Xu B, Jin L, Wang T, Jia W,  FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression  Clin Epigenetics  2018  10:113 
    , Jia W  Diabetes in China: epidemiology, genetic risk factors and their clinical utility in personalized medication  Diabetes  2018  2018, 67(1): 3-11 
    Wang S, Zhang R, Hou X, Jiang F, Wang J, He Z, Jiang F,, Jia W  Association between serum somatostatin levels and glucose-lipid metabolism in the Jino ethnic minority and Han Chinese population  Sci China Life Sci  2018  61(11):1382-1388 
    Liu H, Zhang H, Wang X, Yu X,, Zhang X.   The family Coriobacteriaceae is a potential contributor to the beneficial effects of Roux-en-Y gastric bypass on type 2 diabetes  Surg Obes Relat Dis  2018  14(5):584-593 
    Wang T, Zhang R, Ma X, Wang S, He Z, Huang Y, Xu B, Li Y, Zhang H, Jiang F, Bao Y,, Jia W  Causal Association of Overall Obesity and Abdominal Obesity with Type 2 Diabetes: A Mendelian Randomization Analysis.Obesity (Silver Spring).  Obesity (Silver Spring)  2018  26(5):934-942 
    Wang S, Wang J, Zhang R, Wang T, Yan D, He Z, Jiang F,, Jia W  Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients  Cardiovasc Diabetol  2018  17(1):14 
    Zhao J, Liu X, Yu X, Wang T, Jiao Y, Lu J, Xiong X, Jiang J, Zhang H, Yang Y, Tang Q, Gao X, Lu Y, Liu B,, Li X.  F-box and WD repeat domain- containing 7 promotes degradation of Fetuin A to protect mice from insulin resistance  Diabetes  2018  67(5):818-830 
    Yan D, Wang J, Hou X, Bao Y, Zhang Z,, Jia W  Association of serum uric acid with osteoporosis and bone turnover markers in a Chinese population  Acta Pharmacol Sin  2018  39(4):626-632 
    Li Q, Yu H, Chen M, Jiang F, Zhou J, Bao YQ,, Jia W  Waist circumference-dependent peripheral monocytes change after gliclazide treatment for Chinese type 2 diabetic patients  J Huazhong Univ Sci Technolog Med Sci  2017  37(2):204-9 
    Wang J, Yan D, Bao Y,, Zhang ZL, Jia W.  Association of fat distribution with osteoporosis and bone turnover markers in the Chinese population  Osteoporosis Int  2017  28(9):2645–2652 
    Wang J, Yan D, Hou X, Bao Y,, Zhang ZL, Jia W  Association of bone turnover markers with glucose metabolism in the Chinese population  Acta Pharmacol Sin  2017  38(12):1611-1617 
    Peng D, Wang J, Zhang R, Jiang F, Wang T, Chen M, Yan J, Wang S, Yan D, He Z, Bao Y,, Jia W  CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.  Sci Rep  2017  7(1):8812 
    Wang T, Ma X, Tang T, Higuchi K, Peng D, Zhang R, Chen M, Yan J, Wang S, Yan D, He Z, Jiang F, Bao Y, Jia W, Ishida K,  The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations  Nutr Diabetes  2017  7(5):e278. 
    Li Q, Tang T, Jiang F, Zhang R, Chen M, Yin J, Bao Y, Cheng X,, Jia W.  Polymorphisms of the KCNQ1 are associated with the therapeutic effects of sulfonylureas in Chinese patients with type 2 diabetes.  Acta Pharmacol Sin  2017  38(1):80-89 
    Yan J, Jiang F, Zhang R, Xu T, Zhou Z, Ren W, Peng D, Liu Y,, Jia W  Whole-exome sequencing identifies a novel INS mutation causative of Maturity-Onset Diabetes of the Yong 10  J Mol Cell Biol  2017  9(5):376-383 
    Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, Long J, Wu Y, Wang YX, Takeuchi F, Wu JY, Jung KJ,, Akiyama K, Zhang Y, Moon S, Johnson TA, Li H, Dorajoo R, He M, Cannon ME, Roman TS, Salfati E, Lin KH, Guo X, Sheu WH, Absher D, Adair LS, Assimes TL, Aung T, Cai Q, Chang LC, Chen CH, Chien LH, Chuang LM, Chuang SC, Du S, Fan Q, Fann CS, Feranil AB, Friedlander Y, Gordon-Larsen P, Gu D, Gui L, Guo Z, Heng CK, Hixson J, Hou X, Hsiung CA, Hu Y, Hwang MY, Hwu CM, Isono M, Juang JJ, Khor CC, Kim YK, Koh WP, Kubo M, Lee IT, Lee SJ, Lee WJ, Liang KW, Lim B, Lim SH, Liu J, Nabika T, Pan WH, Peng H, Quertermous T, Sabanayagam C, Sandow K, Shi J, Sun L, Tan PC, Tan SP, Taylor KD, Teo YY, Toh SA, Tsunoda T, van Dam RM, Wang A, Wang F, Wang J, Wei WB, Xiang YB, Yao J, Yuan JM, Zhang R, Zhao W, Chen YI, Rich SS, Rotter JI, Wang TD, Wu T, Lin X, Han BG, Tanaka T, Cho YS, Katsuya T, Jia W, Jee SH, Chen YT, Kato N, Jonas JB, Cheng CY, Shu XO, He J, Zheng W, Wong TY, Huang W, Kim BJ, Tai ES, Mohlke KL, Sim X  Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels  Hum Mol Genet  2017  26(9):1770-1784 
    Deng Z, Gu Y, Hou X, Zhang L, Bao Y,, Jia W  Association between uric acid, cancer incidence and mortality in patients with type 2 diabetes: Shanghai diabetes registry study  Diabetes Metab Res Rev  2016  32(3):325-32 
    Yan J, Peng D, Jiang F, Zhang R, Chen M, Wang T, Yan D, Wang S, Hou X, Bao Y,, Jia W  Impaired pancreatic beta cell compensatory function is the main cause of type 2 diabetes in individuals with high genetic risk: a 9-year prospective cohort study in the Chinese population  Diabetologia  2016  59(7): 1458-62 
    Li Q, Tang T, Jiang F, Zhang R, Chen M, Yin J, Bao Y, Cheng X,, Jia W  Polymorphisms of the KCNQ1 are associated with the therapeutic effects of sulfonylureas in Chinese patients with type 2 diabetes  Acta Pharmacol Sin  2016  epub 
    , Jia W  Linking MTNR1B variants to diabetes: the role of circadian rhythms.  Diabetes  2016  65(6): 1490-2 
    Wang T, Ma X, Tang T, Jin L, Peng D, Zhang R, Chen M, Yan J, Wang S, Yan D, He Z, Jiang F, Cheng X, Bao Y, Liu Z,, Jia W  Overall and central obesity with insulin sensitivity and secretion in a Han Chinese population: A mendelian randomization analysis  Int J Obes  2016  40(11):1736-1741 
    Yan D, Wang J, Jiang F, Zhang R, Sun X, Wang T, Wang S, Peng D, He Z, Bao Y,, Jia W  Association between serum uric acid related genetic loci and diabetic kidney disease in the Chinese type 2 diabetes patients  J Diabetic Complications  2016  30(5):798-802 
    Jiang G,, Tam CH, Lau ES, Wang Y, Luk AO, Yang X, Kong AP, Ho JS, Lam VK, Lee HM, Wang J, Zhang R, Tsui SK, Ng MC, Szeto CC, Jia W, Fan X, So WY, Chan JC, Ma RC  Genetic and clinical variables identify predictors for chronic kidney disease in type 2 diabetes  Kidney Int  2016  89(2):411-20 
    He Z,, Jia W  MiRNAs in Non-alcoholic Fatty Liver Disease  Front Med  2016  10(4):389-396 
    Liu X,, Bao M, Li J, Liu X, Tan X, Zhou Y, Chen Y, Wu S, Chen S, Zhang R, Jiang F, Jia W, Wang X, Yang X, Cai J  Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension  Sci Rep  2016  6:30811 
    Liu Y, Prentice KJ, Eversley JA,, Batchuluun B, Leavey K, Hansen JB, Wei DW, Cox B, Dai FF, Jia W, Wheeler MB  Rapid elevation in CMPF may act as a tipping point in diabetes development  Cell Rep  2016  S2211-1247(16)30214-5 
    Wang T, Ma X, Peng D, Zhang R, Sun X, Chen M, Yan J, Wang S, Yan D, He Z, Jiang F, Bao Y,, Jia W.  Effects of obesity related genetic variations on visceral and subcutaneous fat distribution in a Chinese population  Sci Rep  2016  6:20691 
    Chen M, Zhang R, Jiang F, Wang J, Peng D, Yan J, Wang S, Wang T, Bao Y,, Jia W  Joint effects of diabetic-related genomic loci on the therapeutic efficacy of oral anti-diabetic drugs in Chinese type 2 diabetes patients  Sci Rep  2016  6: 23266. 
    Yan D, Wang J, Jiang F, Zhang R, Wang T, Wang S, Peng D, He Z, Chen H, Bao Y,, Jia W.  A causal relationship between uric acid and diabetic macrovascular disease in Chinese type 2 diabetes patients: a Mendelian randomization analysis.  Int J Cardiol  2016  214:194-9. 
    Yan Y, Zhou Z, Kong F, Feng S, Li X, Wang S, Sha Y, Zhang G, Liu H, Zhang H,, Zhang X  Roux-en-Y gastric bypass surgery suppresses hepatic gluconeogenesis and increases intestinal gluconeogenesis in a T2DM rat model  Obes Surgery  2016  epub 
    Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A,, Moon S, Long J, Kwak SH, Rasheed A, Saxena R, Ma RC, Okada Y, Iwata M, Hosoe J, Shojima N, Iwasaki M, Fujita H, Suzuki K, Danesh J, J?rgensen T, J?rgensen ME, Witte DR, Brandslund I, Christensen C, Hansen T, Mercader JM, Flannick J, Moreno-Macías H, Burtt NP, Zhang R, Kim YJ, Zheng W, Singh JR, Tam CH, Hirose H, Maegawa H, Ito C, Kaku K, Watada H, Tanaka Y, Tobe K, Kawamori R, Kubo M, Cho YS, Chan JC, Sanghera D, Frossard P, Park KS, Shu XO, Kim BJ, Florez JC, Tusié-Luna T, Jia W, Tai ES, Pedersen O, Saleheen D, Maeda S, Kadowaki T  Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes  Nat Commun  2016  7:10531 
    Todd JN, Poon W, Lyssenko V, Groop L, Nichols B, Wilmot M, Robson S, Enjyoji K, Herman MA,, Zhang R, Jia W, Ma R, Florez JC, Friedman DJ  Variation in Glucose Homeostasis Traits Associated With P2RX7 Polymorphisms in Mice and Humans.  J Clin Endocrinol Metab  2015  100(5):E688-96 
    Hwang JY, Sim X, Wu Y, Liang J, Tabara Y,, Hara K, Tam CH, Cai Q, Zhao Q, Jee S, Takeuchi F, Go MJ, Hee Ong RT, Ohkubo T, Kim YJ, Zhang R, Yamauchi T, So WY, Long J, Gu D, Lee NR, Kim S, Tomohiro K, Oh J, Liu J, Umemura S, Kim YJ, Jiang F, Maeda S,   Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.  Diabetes  2015  64(1):291-8 
    Yan J,, Jiang F, Zhang R, Wang J, Tang S, Peng D, Chen M, Bao Y, Jia W  Genetic variants of PLA2G6 are associated with Type 2 diabetes mellitus and triglyceride levels in a Chinese population  Diabetic Med  2015  32(2):280-286 
    Chen M,, Zhang R, Jiang F, Wang J, Peng D, Tang S, Sun X, Yan J, Luo Y, Bao Y, Jia W  A variant of the PSMD6 gene is associated with the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.  Sci Rep  2015  5:10701 
    Wang T, Jia W,  Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies.  Front Med  2015  9(2):146-61 
    Gao T, Jin K, Chen P, Jin H, Yang L, Xie X, Yang M,, Yu X  Circulating betatrophin correlates with triglycerides and postprandial glucose among different glucose tolerance statuses-A case-control study.   PLoS One  2015  10(9) 
    Zhang S, Yang L, Chen P, Jin H, Xie X, Yang M, Gao T,, Yu X.   Circulating adipocyte fatty acid binding protein levels are associated with irisin in the middle-aged general Chinese population.  PLoS One  2015  11(1):  
    Sun X, Zhang R, Jiang F, Tang S, Chen M, Peng D, Yan J, Wang T, Wang S, Bao Y,, Jia W  Common variants related to serum uric Acid concentrations are associated with glucose metabolism and insulin secretion in a Chinese population.  Plos one  2015  10(1):e0116714 
    Lu J, Hou X, Zhang L,, Zhou J, Pang C, Pan X, Bao Y, Jia W  Associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults and type 2 diabetes.  Diabetes Metab Res Rev  2015  31(4):411-20 
    Peng D, Wang J, Zhang R, Tang S, Jiang F, Chen M, Yan J, Sun X, Wang S, Wang T, Yan D, Bao Y,, Jia W  C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes.  BMC Endocrine Disorders  2015  15(1):8 
    Ni Y, Zhao L, Yu H, Ma X, Bao Y, Rajani C, Loo LWM, Shvetsov YB, Yu H, Chen T, Zhang Y, Wang C,, Su M, Xie G, Zhao A, Jia W, Jia W.   Circulating unsaturated fatty acids delineate the metabolic status of obese individuals.  EBioMedicine  2015  2(10):1513-22 
    Peng D, Wang J, Zhang R, Jiang F, Tang S, Chen M, Yan J, Sun X, Wang S, Wang T, Yan D, Bao Y,, Jia W  Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.  Diabetologia  2015  58(6): 1231-8 
    Yan D, Tu Y, Jiang F, Zhang R, Sun X, Wang T, Wang S, Bao Y,, Jia W  Uric acid is independently associated with diabetic kidney disease: a cross-sectional study in a Chinese population.  PLoS One  2015  10(6): e0129797 
    Peng D, Wang J, Zhang R, Tang S, Jiang F, Chen M, Yan J, Sun X, Wang S, Wang T, Yan D, Bao Y,, Jia W.  C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes.  BMC Endocrine Disorders  2015  15(1):8 
    Jiang F, Wang J, Zhang R, Chen M, Peng D, Sun X, Yan J, Luo Y, Tang S,, Jia W  Effects of active and passive smoking on development of cardiovascular disease as assessed by carotid intima-media thickness examination in patients with type 2 diabetes mellitus.  Clin Exp Pharmacol Physiol   2015  42(5):444-50 
    Lu J, Hou X, Zhang L, Jiang F,, Bao Y, Jia W  Association between body mass index and diabetic retinopathy in Chinese patients with type 2 diabetes.  Acta Diabetol  2015  52(4):701-8 
    Tang S, Zhang R, Jiang F, Wang J, Chen M, Peng D, Yan J, Wang S, Bao Y,, Jia W  Circulating irisin levels are associated with lipid and uric acid metabolism in a Chinese population  Clin Exp Pharmacol Physiol  2015  42(9): 896-901 
    Chen M,, Jia W  Pharmacogenomics of glinides  Pharmacogenomics  2015  16(1):45-60 
    Peng D, Jiang F, Zhang R, Tang S, Chen M, Yan J, Sun X, Luo Y,, Jia W  Association of TLR4 genetic polymorphisms with susceptibility to type 2 diabetes mellitus in the Chinese population  Journal of Diabetes  2014  7(4): 485-492 
    Sun X, Yu W,  Genetics of type 2 diabetes in the Chinese individuals.  Biomed Res Int  2014  2014(2014):926713- 
    Chen M,, Zhang R, Jiang F, Wang J, Peng D, Tang S, Sun X, Yan J, Luo Y, Bao Y, Jia W  Association of PAX4 genetic variants with oral antidiabetic drugs efficacy in Chinese type 2 diabetes patients  The Pharmacogenomics Journal  2014  14(5):488-492 
    Zhao Y, Hong N, Wu B, Liu X, Tang S, Yang J,, Jia W.   A novel mutation in Leptin gene is associated with severe obesity in Chinese individuals.   Biomed Res Int  2014  2014(2014):912052- 
    Sun X, Jiang F, Zhang R, Tang S, Chen M, Peng D, Yan J, Wang T, Wang S, Bao Y,, Jia W  Serum uric acid levels are associated with polymorphism in the SLC2A9, SF1 and GCKR genes in a Chinese population  Acta Pharmacol Sin  2014  35(11):1421-1427 
    Ma RC,, Tam CH, Zhang R, Kwan P, Leung TF, Thomas GN, Go MJ, Hara K, Sim X, Ho JS, Wang C, Li H, Lu L, Wang Y, Li JW, Wang Y, Lam VK, Wang J, Yu W, Kim YJ, Ng DP, Fujita H, Panoutsopoulou K, Day-Williams AG, Lee HM, Ng AC, Fang YJ, Kong AP, Jiang F,   Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4  Diabetologia  2013  56(6):1291-305 
    Cho YS, Chen CH,, Long J, Ong RTH, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RCW, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu F, Kim HL, Kim S, Kim YJ, Lee JJM, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nak  Meta-analysis of genome-wide association studies identifies 8 new loci for type 2 diabetes in east Asians  Nat Genet  2012  44(1):67-72 
    Yu W, Ma RC,, So WY, Zhang R, Wang C, Tam CH, Ho JS, Lu J, Jiang F, Tang S, Ng MC, Bao Y, Xiang K, Jia W, Chan JC  Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes  Diabetologia  2012  55(10):2655-9 
    Yu W,, Jia W  Genetic advances of type 2 diabetes in Chinese populations.  J Diabetes  2012  4(3):213-20 
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    , Zhang R, Wang C, Ma X, Wang J, Bao Y, Xiang K, Jia W  Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese population  BMC Med Genet  2011   
    Kim YJ, Go MJ,, Hong CB, Kim YK, Lee JY, Hwang JY, Oh JH, Kim DJ, Kim NH, Kim S, Hong EJ, Kim JH, Min H, Kim Y, Zhang R, Jia W, Okada Y, Takahashi A, Kubo M, Tanaka T, Kamatani N, Matsuda K, Park T, Oh B, Kimm K, Kang D, Shin C, Cho NH, Kim HL, Han B  New multiple genetic loci for metabolic traits identified from large scale East Asian genome-wide association studies  Nat Genet  2011  43(10):990-995 
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    Ma RCW, Tam CHT, Wang Y, Luk AO,, Yang X, Lam V, Chan AWH, Ho JSK, Chow CC, Tong PCY, Jia W, Ng MCY, So WY, Chan JCN  Genetic variants of the protein kinase C-β 1 gene and development of end-stage renal disease in patients with type 2 diabetes  JAMA  2010  304(8):881-889 
    Bao Y, Ma X, Li H, Zhou M,, Wu H, Tang J, Hou X, Xiang K, Jia W  Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological survey  BMJ  2010  340:c2249 
    , Zhang R, Wang C, Wang J, Ma X, Hou X, Lu J, Yu W, Jiang F, Bao Y, Xiang K, Jia W  Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese  PLOS ONE  2010  5(11):- 
    , Wang C, Zhang R, Ng MC, Bao Y, Wang C, So WY, Ma RC, Ma X, Chan JC, Xiang K, Jia W  Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population  Diabetologia  2010  53(2): 290-298 
    , Zhang R, Wang C, Yu W, Lu J, Ma X, Wang J, Jiang F, Tang S, Bao Y, Xiang K, Jia W.  The effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion  PLOS ONE  2010  5(7):- 
    , Zhang R, Wang C, Ma X, Wang C, Fang Q, Bao Y, Xiang K, Jia W  A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose levels in the Chinese population  Diabetologia  2009  52(3):451-456 
    Wang C,, Zhang R, Bao Y, Ma X, Qin W, Shao X, Lu J, Lu J, Lu H, Xiang K, Jia W  Common variants of hepatocyte nuclear factor 1B are associated with type 2 diabetes in a Chinese population  Diabetes  2009  58(4):1023-1027 
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    , Zhang R, Wang C, Wang J, Ma X, Lu J, Qin W, Hou X, Wang C, Bao Y, Xiang K, Jia W  PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population  PLoS ONE  2009  4(10): e7643 
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    , Jia W, Zhang R, Wang C, Lu J, Wu H, Fang Q, Ma X, Xiang K  Effect of RBP4 gene variants on circulating RBP4 concentration and Type 2 diabetes in Chinese population  Diabetic Med  2008  25(1):11-18 
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