- 基本信息
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导师姓名：
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肖泽宇
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学科代码：
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100700
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性别：
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女
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学科名称：
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药学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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(021)63846590 ext.776415
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专业领域代码：
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邮编：
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邮箱地址：
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xiaozeyu@shsmu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国抗癌协会纳米肿瘤学专委会委员
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中国化学会分子医学专委会委员
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中国化学会女化学工作者委员会委员
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美国化学会Anal Chem 顾问编委
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- 科研项目
| 2022XD033 | 上海市卫生健康学科带头人 | 上海市卫生健康委员会 |
2023-01~2025-12
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45万元
| 课题负责人 |
| 52161160307 | 功能模块化光动力药物用于克服非小细胞肺癌旁路激活耐药及序贯疗效监控 | 国家自然科学基金国际（地区）合作项目 |
2022-01~2024-12
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180万元
| 课题负责人 |
| 2020YFA0210803 | 多模块可编程纳米药物的活体动态可视化研究 | 国家重点研发计划 |
2020-11~2025-10
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212万元
| 课题负责人 |
| 2020 | 新型冠状病毒核酸现场快速检测设备及试剂的研发 | 国家重点研发计划 |
2020-02~2020-04
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100万元
| 课题参与人 |
| 2020 | 家庭简易式新型冠状病毒感染自查技术与试剂盒 | 上海交通大学医工交叉研究基金重点项目 |
2020-02~2021-01
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100万元
| 课题参与人 |
| 21874092 | 拉曼纳米探针用于活性氧异常疾病的医学分析研究 | 国家自然科学基金 |
2019-01~2022-12
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64万元
| 课题负责人 |
| 81741014 | SP-A核酸适体拉曼纳米探针用于胎肺发育及异常的产前诊断研究 | 国家自然科学基金 |
2018-01~2018-12
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20万元
| 课题负责人 |
| 31671003 | 核酸识体纳米药物在组织脏器的三维精准分布及靶向识别 | 国家自然科学基金 |
2017-01~2020-12
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62万元
| 课题负责人 |
| 81471779 | DNA自主装纳米诊疗系统：构建及术中成像介导下前列腺癌细胞清除的问题研究 | 国家自然科学基金 |
2015-01~2018-12
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73万元
| 课题负责人 |
| 2014 | 上海市高层次人才计划 | 上海市教委 |
2015-01~2017-12
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100万元
| 课题负责人 |
| 2014 | 国家高层次青年人才计划 | 中组部 |
2015-01~2017-12
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200万元
| 课题负责人 |
| 2014 | 课题启动经费 | 上海交大医学院 |
2014-08~2019-12
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200万元
| 课题负责人 |
- 学术论文
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Cui K, Li R, Zhang Y, Qiu Y,Zhao N, Cui Y, Wu W, Liu T,
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Molecular Planarization of Raman Probes to Avoid Background Interference for High-Precision Intraoperative Imaging of Tumor Micrometastases and Lymph Nodes
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Nano Lett.
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2022
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in press
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Cui K, Zhang Y, Chen G, Cui Y, Wu W, Zhao N, Liu T,
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Molecular regulation of polymeric Raman probes for ultrasensitive microtumor diagnosis and noninvasive microvessle imaging.
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Small
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2022
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2106925
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Xia F, He A, Zhao H, Sun Y, Duan Q, Abbas S J, Liu J*,,Tan W*
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Molecular Engineering of Aptamer Self-assemblies Increases in Vivo Stability and Targeted Recognition.
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ACS Nano
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2022
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16,1,169-179
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Zhang Y, Cui Y, Li M, Cui K, Li R, Xie W, Liu L,
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DNA-assembled visible nanodandelions with explosive hydrogen-bond breakage achieving uniform intra-tumor distribution (UITD)-guided photothermal therapy.
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Biomaterials
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2022
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282，121381
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Fan C, Zhao N, Cui K, Chen G, Chen Y, Wu W, Li Q, Cui Y, Li R,
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Ultrasensitive Exosome Detection by Modularized SERS Labeling for Postoperative Recurrence Surveillance.
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ACS Sens.
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2021
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6(9):3234-3241
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Gao S, Yu S, Zhang Y, Wu A, Zhang S, Wei G, Wang H*,,Lu W*
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Molecular engineering of near-Infrared-II photosensitizers with steric-hindrance effect for image-guided cancer photodynamic therapy.
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Adv. Func. Mater.
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2021
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31(14), 2008356
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Zhao N, Chen Y, Chen G,
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Artificial cells based on DNA nanotechnology.
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ACS Applied Bio Materials
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2020
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3,3928-3934
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Gao S, Wei G, Zhang S, Zheng B, Xu J, Chen G, Li M, Song S, Fu W,, Lu W*
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Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics.
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Nat Commun.
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2019
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10(1):2206
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Gu X, Qiu Y, Lin M, Cui K, Chen G, Chen Y, Fan C, Zhang Y, Xu L, Chen H, Wan JB, Lu W,
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CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance.
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Nano Lett.
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2019
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19(5):3344-3352
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Xu J, Yu S, Wang X, Qian Y, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, Fu W,,Lu W*
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High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy.
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ACS Nano
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2019
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13,10242-10260
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Qiu Y, Lin M, Chen G, Fan C, Li M, Gu X, Cong S, Zhao Z, Fu L, Fang X,
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Photodegradabl CuS SERS probes for intraoperative residual tumor detection, ablation and self-clearance.
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ACS Appl Mater Interfaces
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2019
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11(26):23436-23444
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Zheng B, Xu J, Chen G, Zhang S,, Lu W*
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Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity.
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Adv. Func. Mater.
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2019
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29(33),1901437
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Wu W,
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A deep learning “ticket” for single-molecule analysis of protein stoichiometry
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Sci China Chem
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2019
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62，1269-1270
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Qiu Y, Zhang Y, Li M, Chen G, Fan C, Cui K, Wan J, Han A, Ye J*,
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Intraoperative detection and eradication of residual microtumors with gap-enhanced Raman tags.
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ACS Nano
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2018
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12(8):7974-7985
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Cui K, Fan C, Chen G, Qiu Y, Li M, Lin M, Wan JB, Cai C,
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para-Aminothiophenol Radical Reaction-Functionalized Gold Nanoprobe for One-to-All Detection of Five Reactive Oxygen Species in Vivo.
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Anal Chem
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2018
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90, 12137-12144
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Li M, Qiu Y, Fan C, Cui K, Zhang Y,
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Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures.
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Acta Pharm Sin B.
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2018
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8(3):381-389
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Zhang Y, Qiu Y, Lin L, Gu H,, Ye J*
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Ultraphotostable Mesoporous Silica-Coated Gap-Enhanced Raman Tags (GERTs) for High-Speed Bioimaging.
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ACS Appl Mater Interfaces
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2017
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9(4):3995-4005
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Qi Q, Lu L, Li H, Yuan Z, Chen GX, Lin M, Ruan Z, Ye X*,, Zhao Q*
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Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction.
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Int J Nanomedicine
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2017
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12:4835-4848
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Lu L, Chen G, Qiu Y, Li M, Liu D, Hu D, Gu X,
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Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies.
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Sci Bull
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2016
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61(9):670-681
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CuS Nanoparticles: clinically favorable materials for photothermal therapy
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Nanomedicine
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2014
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9(3):373-5
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Wu J, Kamaly N, Shi J, Zhao L,, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW, Farokhzad OC
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Development of multinuclear polymeric nanoparticles as robust protein nanocarriers
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Angew Chem Int Ed Engl
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2014
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53(34):8975-9
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, Farokhzad OC
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Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities
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ACS Nano
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2012
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6(5):3670-3676
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, Ji C, Shi J, Pridgen E, Frieder J, Wu J, Farokhzad OC
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DNA self-assembly of targeted near infrared-responsive gold nanoparticles for cancer thermo-chemotherapy
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Angew Chem Int Ed Engl
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2012
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51(47):11853-11857
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, Levy-Nissenbaum E, Alex F, Luptak A, Teply B, Chan J, Shi J, Diggar E, Cheng J, Langer R, et al.
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Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection
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ACS Nano
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2012
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6 (1):696-704
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Kamaly N,,Valencia PM, Radovic-Moreno AF, Farokhzad OC
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Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
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Chem Soc Rev
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2012
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41(7):2971-3010
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Shi J,, Kamaly N, Farokhzad OC
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Self-assembled Targeted Nanoparticles: Evolution of Technologies and Bench to Bedside Translation
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Acc Chem Res
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2011
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44(10):1123-34
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Shi J,, Votruba AR, Viols C, Farokhzad OC
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Differently Charged Hollow Core/shell Lipid-polymer-lipid Hybrid Nanoparticles for Small Interfering RNA Delivery
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Angew Chem Int Ed Engl
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2011
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50(31):7027-7031
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Gao W,, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC
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Progress in siRNA Delivery: A Multifunctional Approach by Polymeric Nanoparticles
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Methods in Mol Biol
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2010
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629(1):53-67
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Zhang W, Jiang Y, Wang Q, Ma X,, Zuo W, Fang X, Chen Y
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Single Molecule Imaging Reveals Transforming Growth Factor-β-induced Type II Receptor Dimerization
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Proc Natl Acad Sci U S A
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2009
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106(37):15679-15683
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Liu Q, Chen B, Wang Q, Shi X,, Lin J, Fang X
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Carbon Nanotubes as Molecular Tansporters for Walled Plant Cells
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Nano Lett
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2009
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9(3):1007-1010
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, Shangguan D, Cao ZC, Fang X, Tan W
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Cell-specific Internalization Study of an Aptamer from Whole Cell Selection
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Chemistry
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2008
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14(6):1769-1775
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Yang R, Jin J, Chen Y, Shao N, Kang H,, Tang Z, Wu Y, Zhu Z, Tan W.
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Identification of Liver Cancer-Carbon Nanotube-Quenched Fluorescent Oligonucleotides: Probes that Fluoresce upon Hybridization
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J.Am.Chem.Soc
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2008
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130(26):8351–8358
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, Zhang W, Yang Y, Xu L, Fang X
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Single-molecule diffusion study of activated EGFR implicates its endocytic pathway
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Biochem Biophys Res Commun
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2008
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369(2):730-734
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, Ma X, Jiang Y, Liao J, Yue J, Fang X
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Single-Molecule Study of Lateral Mobility of Epidermal Growth Factor Receptor 2/HER2 on Activation
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J Phys Chem B
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2008
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112(13):4140-4145
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Shangguan D, Meng L, Cao Z,, Fang X, Li Y, Cardona D, Witek RP, Liu C, Tan W.
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Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells
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Anal Chem
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2008
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80(3):721-728
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Shangguan D, Tang Z, Mallikaratchy P,, Tan W
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Optimization and Modifications of Aptamers Selected from Live Cancer Cell Lines
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Chembiochem
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2007
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8(6):603-606
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Ma X, Wang Q, Jiang Y,, Fang X, Chen Y
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Optimization and Modifications of Lateral Diffusion of TGF-? Type I Receptor Studied by Single-Molecule Imaging
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Biochem Biophys Res Commun
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2007
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356(1):67–71
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Xu W,, Zhang T
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Mechanical Properties of Silicone Elastomer on Temperature in Biomedical Application
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Materials Letters
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2005
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59(17):2153-2155
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