- 基本信息
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导师姓名：
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陈皓
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学科代码：
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100210
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性别：
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男
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学科名称：
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外科学
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培养单位：
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附属瑞金医院
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三级学科
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普外
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导师类型：
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博士生导师
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专业领域名称：
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外科学 专业学位
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联系方式：
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上海交通大学医学院附属瑞金医院10号楼9楼胰腺外科一病区
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专业领域代码：
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105111
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邮编：
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200025
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邮箱地址：
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haochendr@126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会外科分会门脉高压组委员，上海市医学会普外分会门脉高压学组组长
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- 科研项目
| 81470894 | LncRNA-Cox2在肝脏热缺血－再灌注损伤中对TLR4激活调控 | 国家自然科学基金面上项目 |
2015-01~2019-12
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73万元
| 课题负责人 |
| 81070356 | 以 AAV8 为平台转染TLR4 胞内区TIR 竞争性结合多肽基因对小鼠肝脏热缺血－再灌注损伤的保护作用 | 国家自然科学基金面上项目 |
2011-01~2013-12
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32万元
| 课题负责人 |
| 09411952200 | 肝脏缺血－再灌注损伤中霉酚酸对肝脏树突状细胞TLR4表达及调控的影响 | 上海市科委 |
2009-07~2012-07
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25万元
| 主要责任人 |
| 08ZR1414200 | 肝移植受者霉酚酸（MPA）药效学基础和临床研究 | 上海市科委 |
2008-10~2010-10
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10万元
| 主要责任人 |
| 08ZR1414200 | 肝移植受者霉酚酸（MPA）药效学基础和临床研究 | 上海市科委，自然科学基金 |
~2010-09
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10万元
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- 学术论文
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Zengyu Feng, Minmin Shi, Kexian Li, Yang Ma, Lingxi Jiang,, Chenghong Peng.
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Development and validation of a cancer stem cell-related signature for prognostic prediction in pancreatic ductal adenocarcinoma.
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J Transl Med.
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2021
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18(1):360
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Meilin Xue, Minmin Shi, Junjie Xie, Jun Zhang, Lingxi Jiang, Xiaxing Deng, Chenghong Peng, Baiyong Shen, Hong Xu,
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Serum tRNA-derived small RNAs as potential novel diagnostic biomarkers for pancreatic ductal adenocarcinoma.
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Am J Cancer Res.
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2021
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11(3):837
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Shuyu Zhai, Zhiwei Xu, Junjie Xie, Jun Zhang, Xinjing Wang, Chenghong Peng, Hongwei Li,, Baiyong Shen, Xiaxing Deng.
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Epigenetic silencing of LncRNA LINC00261 promotes c-myc-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1.
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Oncogene
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2021
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40(2):277
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Cheng Xiong, Youwei Zhu, Meilin Xue, Yongsheng Jiang, Yiming Zhong, Lingxi Jiang, Minmin Shi,
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Tumor-associated macrophages promote pancreatic ductal adenocarcinoma progression by inducing epithelial-to-mesenchymal transition.
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Aging (Albany NY).
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2021
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13(3):3386
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Zhang B, Song L, Cai J, Li L, Xu H, Li M, Wang J, Shi M,, Jia H, Hou Z.
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The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation.
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J Exp Clin Cancer Res
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2019
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38(1):205
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Wu J, Li H, Shi M, Zhu Y, Ma Y, Zhong Y, Xiong C,, Peng C.
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TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells
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J Exp Clin Cancer Res
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2019
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38(1):348
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Zhong Y, Zhu Y, Dong J, Zhou W, Xiong C, Xue M, Shi M,
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Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver Ischemia/Reperfusion Injury.
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Biomed Res Int
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2019
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2019:8962682.
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Gu J, Xu W, Peng C, Zhu Y, Wang D, Wang X, Li Y, Wei G, Zhang Z, Zhong Y, Zhao S, Shi M, Cheng D, Ying X, Jin J,
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Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer.
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J Cell Biochem
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2019
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120(7):11775
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Wu J, Li H, Shi M, Zhu Y, Ma Y, Zhong Y, Xiong C,, Peng C.
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TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells.
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J Exp Clin Cancer Res
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2019
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38(1):348
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Zhong Y, Zhu Y, Dong J, Zhou W, Xiong C, Xue M, Shi M,
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Identification of Key Transcription Factors AP-1 and AP-1-Dependent miRNAs Forming a Co-Regulatory Network Controlling PTEN in Liver Ischemia/Reperfusion Injury.
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Biomed Res Int
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2019
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Nov 5;2019:8962682
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Huang SW,, Lu ML, Wang JL, Xie RL, Zhao B, Chen Y, Xu ZW, Fei J, Mao EQ, Chen EZ
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Mycophenolate Mofetil Protects Septic Mice via the Dual Inhibition of Inflammatory Cytokines and PD-1
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Inflammation
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2018
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41(3):1008-1020
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Zhu Y, Gu J, Li Y, Peng C, Shi M, Wang X, Wei G, Ge O, Wang D, Zhang B, Wu J, Zhong Y, Shen B,
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MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes
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Cancer Letters
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2018
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412:59-68
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Chen W, Ma L, Li R, Huang S, Xie R, Chen Y, Zhao B, Fei J, Qu H,, Mao E, Chen EZ
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Dc-Sign Expression in Intestinal Epithelial Cells Regulates Sepsis-Associated Acute Intestinal Injury via Activating ERK1/2-NF-κB/P65 Signaling
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Shock
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2018
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52(4):434-442
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Liu C, Wang J, Yuan X, Qian W, Zhang B, Shi M, Xie J, Shen B, Xu H, Hou Z,
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Long noncoding RNA uc.345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression
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Oncotarget
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2016
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7(44):71556-71566
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, 杨卫平, 李宏为
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肝移植时代传统外科手术在肝硬化门静脉高压症中的治疗地位
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外科理论与实践
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2016
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21(5):372-4
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Zhu Y, Shi M,, Gu J, Zhang J, Shen B,, Deng X, Xie J, Zhan X, Peng C
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NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells.
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Oncotarget
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2015
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6(25):21443-51
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Zhu Y, Xu H,, Xie J, Shi M, Shen B, Deng X, Liu C, Zhan X, Peng C.
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Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway.
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Mol Cell Proteomics
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2014
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13(10)：2593-603
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He Meimei, Min Dejin, Chen Erzhen, Shi Minmin, Jiang Songyao, Li Jianfang,
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Inhibiting the TLR4 Toll/IL-1 receptor domain protects against hepatic warm ischemia and reperfusion injury in mice.
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Crit Care Med
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2014
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42(2): e123-31.
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Jianfang L, Junjie X, Mingming S, Jiabin J, Baiyong S, Xiaxing D, Xi Z,
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Up-regulation of toll-like receptors 2 and 4 on peripheral monocytes after major abdominal surgical operation.
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Dig Dis Sci.
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2013
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58(4):942-9.
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Gu Z, Chen B, Song Y, Shen B, Zhu Z, Zhang W, Xie J, Deng X, Peng C, Fan Q,
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Pharmacokinetics of free mycophenolic acid and limited sampling strategy for the estimation of area under the curve in liver transplant patients.
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Eur J Pharm Sci
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2012
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47(4):636-41.
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Xie Junjie, Jiang Songyao, Shi Minmin, Song Yanyan, Shen Baiyong, Deng Xiaxing, Jin Jiabin, Zhan Xi,
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The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility.
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BMC Cancer.
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2012
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12(1):57
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Shi MM, Xu XQ,, Shen BY, Deng XX, Xie JJ, Zhan X, Zhao JQ, Jiang SY.
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Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma.
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PLoS One.
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2011
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6(4):e19466.
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孙广涛, 邱伟华, 施敏敏,
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索拉菲尼对肝癌细胞HepG2自噬的抑制作用.
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外科理论与实践
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2010
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15(1):51-55
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张贵阳, 施敏敏, 张伟霞, 顾志冬, 茅华荣,
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霉酚酸在肝移植受者的药代动力学与药效学相关性研究.
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中国临床药理学杂志
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2010
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26(2):102-105
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Shen B, Chen B, Zhang W, Mao H, Shen C, Deng X, Zhan X,
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Comparison of pharmacokinetics of mycophenolic acid and its metabolites between living donor liver transplant recipients and deceased donor liver transplant recipients.
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Liver Transpl
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2009
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15(11):1473-80
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, Gu Z, Chen B, Mao H, Zhang W, Fan Q
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dels for the prediction of mycophenolic acid area under the curve using a limited-sampling strategy and an enzyme multiplied immunoassay technique in Chinese patients undergoing liver transplantation.
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Clin Ther
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2008
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30(12):2387-2401
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, Anwei M, Bing C, Baiyong S, Weixia Z, Chuan S, Erzhen C, Xiaxing D, Weihua Q, Weiping Y, Chenghong P, Hongwei L.
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Monitoring mycophenolic acid pharmacokinetic parameters in liver transplant recipients: prediction of occurrence of leukopenia.
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Liver Transpl
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2008
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14(8):1165-1173
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, Peng C, Yu Z, Shen B, Deng X, Qiu W, Fei Y, Shen C, Zhou G, Yang W, Li H.
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Pharmacokinetics of mycophenolic acid and determination of area under the curve by abbreviated sampling strategy in Chinese liver transplant recipients.
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Clin Pharmacokinet
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2007
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46(2):175-185
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, Erzheng C, Anwei M, Zhicheng Y, Baiyong S, Xiaxing D, Weixia Z, Chenghong P, Hongwei L.
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Validation of limited sampling strategy for the estimation of mycophenolic acid exposure in Chinese adult liver transplant recipients.
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Liver Transpl
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2007
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13(12):1684-93
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, Peng CH, Shen BY, Deng XX, Shen C, Xie JJ, Dong W, Li HW.
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Multi-factor analysis of initial poor graft function after orthotopic liver transplantation.
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Hepatobiliary Pancreat Dis Int
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2007
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6(2):141-146
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茅安炜,, 余自成, 等
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肝移植受者早期霉酚酸药代动力学临床特点.
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诊断学理论与实践
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2007
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6(4):327-330
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, 彭承宏, 邓侠兴, 等.
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阿霉素诱导热休克蛋白72对大鼠肝脏冷缺血-再灌注损伤的保护作用.
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中华外科杂志
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2006
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44(5):310-313
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, 彭承宏, 沈柏用, 等.
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原位肝移术植中逆行灌注对早期移植肝功能的影响.
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上海交通大学学报(医学版)
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2006
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26(6):615-617
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,邱伟华,邓侠兴,等.
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大鼠肝脏热缺血-再灌注损伤中HSP72对肝细胞的保护作用.
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中国微循环
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2006
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10(5):318-321
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, 沈柏用, 邓侠兴, 等.
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HSP 72 mRNA的表达在肝脏热缺血-再灌注损伤中的意义.
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上海交通大学学报(医学版)
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2006
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26(6):599-60
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, 彭承宏, 沈柏用, 等.
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原位肝移植早期肝功能不良危险因素80例分析.
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中国实用外科杂志
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2005
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25(12):727-729
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