• 基本信息
    导师姓名: 郭雪君 学科代码: 100201
    性别: 学科名称: 内科学
    培养单位: 附属新华医院 三级学科 呼吸系病
    导师类型: 博士生导师 专业领域名称: 内科学 专业学位
    联系方式: snowgen@126.com 专业领域代码: 105101
    邮编: 200092 邮箱地址: snowgen@126.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市呼吸内科质量控制中心专家委员会委员
    《Chest》(中文版)执行编委
    中国医师协会呼吸专业委员会委员
    上海医学会呼吸病专业委员会哮喘学组组长
    国际呼吸杂志编委
    上海市微生物学会真菌专业委员会委员
    上海康复医学工程研究会呼吸康复医学研究分会副主任委员
    中华哮喘杂志编委
    海峡医药卫生交流协会呼吸病专业委员会常委
    中华医学会呼吸病分会委员
    上海呼吸病研究所慢性气道疾病临床基地副主任
    《Lancet Respiratory Medicine》(中文版)编委
    中国呼吸病与危重监护杂志 编委
    上海交通大学医学院哮喘临床诊治中心主任
    中国医师协会中西医结合医师分会呼吸病专业委员会常委
    上海医学会呼吸病专业委员会副主任委员
    中华医学会呼吸病分会哮喘病学组委员
    上海交通大学医学院慢性气道疾病临床诊治中心副主任
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81770022芳香烃受体调控MSC功能在中性粒细胞哮喘气道炎症中的作用及机制研究国家自然基金,面上项目 2018-01~2021-12 50万元  课题负责人
    16CR2042B基于计算机人工智能识别系统建立及超声支气管镜和/或微创胸腔镜病理组织活检精准诊断肺结节的临床研究上海申康医院发展中心 2017-07~2019-12 60万元  课题负责人
    14401970500姜黄素对COPD治疗中吸入激素抵抗现象的改善作用上海市科技创新计划重点项目 2014-10~2017-09 25万元  课题负责人
    81170027Notch1信号在骨髓间充质干细胞对COPD上皮细胞修复中的调控作用国家自然基金,面上项目 2014-01~2017-12 75万元  课题负责人
    81170027哮喘中T细胞活化衔接子对调节性T细胞调控研究国家自然科学基金 2012.-01~2015-12 55万元  课题负责人
    30971302哮喘中Notch1对T细胞分化作用的调控研究国家自然科学基金 2010-01~2012-12 31万元  课题负责人
    10jc1411300组蛋白乙酰化、甲基化和DNA甲基化在COPD发病机制中的作用上海市基础研究重点项目 2010.-10~2013-09 30万元  课题负责人
    09JC1410700骨髓间充质干细胞对COPD慢性炎症损伤干预作用及机制探讨上海市基础研究重点项目 2009-10~2011-09 30万元  课题参与人
    09ZZ114T细胞Notch信号胞内外调控因子在哮喘时T细胞分化中的作用上海市教委科研创新重点项目 2009-01~2011-12 15万元  课题负责人
    08020590137呼吸道病毒感染与慢性阻塞性肺疾病(COPD)急性加重的关系中华医学会临床医学科研专项资金 2009-01~2011-12 10万元  课题负责人
    04JC14048T细胞活化衔接子和转录因子Aiolos在哮喘发病机制中作用研究上海市基础研究重点项目 2004-10~2007-09 70万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Ye W, Gu W,, Yi P, Meng Y, Han F, Yu L, Chen Y, Zhang G, Wang X  Detection of pulmonary ground-glass opacity based on deep learning computer artificial intelligence  Biomed Eng Online  2019  18(1):6 
    Cui Z, Liu Z, Zeng J, Chen L, Wu Q, Mo J, Zhang G, Song L, Xu W, Zhang S,  Eugenol inhibits non-small cell lung cancer by repressing expression of NF-B-regulated TRIM59  Phytother Res  2019  33(5):1562-1569 
    Cui Z, Liu Z, Zeng J, Zhang S, Chen L, Zhang G, Xu W, Song L,  TRIM59 promotes gefitinib resistance in EGFR mutant lung adenocarcinoma cells  Life Sci  2019  224: 23-32 
    Peng J, Li XM, Zhang GR, Cheng Y, Chen X, Gu W,  TNF-TNFR2 Signaling Inhibits Th2 and Th17 Polarization and Alleviates Allergic Airway Inflammation  Int Arch Allergy Immunol  2019  178(3):281-290 
    Wenjing Ye,, Tianyun Yang, Fengfeng Han  Systematic review of inhaled corticosteroid withdrawal effects in chronic obstructive pulmonary disease, and comparison with two “real-life” studies  J Thorac Dis  2018  10(7):2904-2914  
    Wenjing Ye, Weiguo Xu,, Juan Peng, Fengfeng Han, Xiaoming Li, Wenbin Guan, Liwei Yu, Jinyuan Sun, Zhilei Cui, Lin Song, Yue Zhang, Yanmin Wang, Tianyun Yang, Xiahui Ge,Di Yao, Song Liu  Differences in Airway Remodeling and Airway Inflammation between Moderate-Severe Asthma Clinical Phenotypes  J Thorac Dis  2017  9(9):2904-2914 
    Y Cheng,W Gu,G Zhang,X Li,  Activation of Notch1 signaling alleviates dysfunction of bone marrow-derived mesenchymal stem cells induced by cigarette smoke extract  International Journal of COPD  2017  12 :3133 
    XM Li,X Chen,W Gu,YJ Guo,Y Cheng,  Impaired TNF/TNFR2 signaling enhances Th2 and Th17 polarization and aggravates allergic airway inflammation  Am J Physiol Lung Cell Mol Physiol  2017  313 (3) :L592 
    Xi Chen, Xiao-ming Li, Wen Gu, Di Wang, Yi Chen,  LAT alleviates Th2/Treg imbalance in an OVA-induced allergic asthma mouse model through LAT-PLC-gamma1 interaction  International immunopharmacology  2017  44:9-15 
    Gu W, Cui R, Ding T, Li X, Peng J, Xu W,, Guo X  Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma  Respirology  2017  22(3):533-541 
    Sibin Guan, Weiguo Xu, Fengfeng Han, Wen Gu, Lin Song, Wenjing Ye, Qian Liu,  Ginsenoside Rg1 Attenuates Cigarette Smoke-Induced Pulmonary Epithelial-Mesenchymal Transition via Inhibition of the TGF-β1/Smad Pathway  BioMed Research International  2017  ID 7171404,1-12 
    Gu W, Cui R, Ding T, Li X, Peng J, Xu W, Han F,  Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma  Respirology  2016  22(3):533–541  
    王帝,?崔志磊,  姜黄素mPEG-PLGA纳米粒对香烟提取物刺激巨噬细胞RAW264.7所致激素抵抗现象逆转作用的研究  中国呼吸与危重监护杂志  2016  15(1):68-74 
    Xiao-ming Li, Juan Peng, Wen Gu,  TCDD-induced activation of aryl hydrocarbon receptor inhibits Th17 polarization and regulates non-eosinophilic airway inflammation in asthma  PLoS ONE  2016  2016; 11(3): e0150551 
    张悦,,?韩锋锋,?皮卫峰,?孙晋渊  31例原发性肺肉瘤样癌临床分析  国际呼吸杂志  2016  2016;1: 6-11 
    Gan L, Li C,, Guo X  Curcumin modulates the effect of histone modification on the expression of chemokines by type II alveolar epithelial cells in a rat COPD model  International Journal of COPD  2016  11:2765-2773 
    Xiahui Ge, Fengfeng Han,  Comparison of Endobronchial Ultrasound-guided Fine Needle Aspiration and Video-assisted Mediastinoscopy for Mediastinal Staging of Lung Cancer  Lung  2015  DOI: 10.1007/s00408-015-9761-3 
    Wen Gu, Lin Song, Xiao-Ming Li, Di Wang,  Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways  Scientific Reports  2015  5:8733 
    Jingjing Feng, Yunwen Hu, Zhigang Song, Yi Liu,, Zhijun Jie  Interleukin-23 facilitates Th1 and Th2 cell differentiation in vitro following respiratory syncytial virus infection  Journal of Medical Virology  2015  87(4). DOI: 10.1002/jmv.24126  
    Min Zhou, Zhi-lei Cui,, Lian-pin Ren, Min Yang, Zhi-wen Fan, Rui-chao Han, Wei-guo Xu  Blockade of Notch Signalling by γ-Secretase Inhibitor in Lung T Cells of Asthmatic Mice Affects T Cell Differentiation and Pulmonary Inflammation  Inflammation  2015  38(3): 1281-1288  
    Xi Chen,  Acetylation of lysine 9 on histone H3 is associated with increased pro-inflammatory cytokine release in a cigarette-smoke induced rat model through HDAC1 depression  Inflammation Research  2015  64( 7): 513-526  
    栾春雨,  姜黄素提高糖皮质激素对慢性阻塞性肺疾病大鼠的抗炎作用研究  中国呼吸与危重监护杂志  2014  13(4):337-342 
    Peng X, Cui Z, Gu W, Xu W,  Low level of LAT-PLC-γ1 interaction is associated with Th2 polarized differentiation: A contributing factor to the etiology of asthma  Cell Immunol  2014  290(1):131-137 
    Lin Song, Xiaojun Guan, Xi Chen, Zhilei Cui,Fengfeng Han,,Weiguo Xu  Mesenchymal Stem Cells Reduce Cigarette Smoke-Induced Inflammation and Airflow Obstruction in Rats via TGF-β1 Signaling  COPD: Journal Of Chronic Obstructive Pulmonary Disease  2014  Posted online on 25 Apr 2014:000-000 
    CY Li, J Peng, LP Ren, LX Gan, XJ Lu, Q Liu, W Gu,  Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma  J Transl Med  2013  11(1): 26 
    Z-L Cui, W Gu, T Ding, X-H Peng,X Chen, C-Y Luan, R-C Han, W-G Xu,  Histone modifications of Notch1 promoter affect lung CD4+ T cell differentiation in asthmatic rats  Int J Immunopathol Pharmacol  2013  26(2):371-382 
    韩锋锋,,郏琴,张悦,王妍敏,李惠民,管雯斌  外源性变应性肺泡炎的临床病理特征和影像学表现  临床肺科杂志  2013  18(6):984-987 
    Xiahui Ge, Fengfeng Han , Yanxi Huang , Yue Zhang ,Tianyun Yang, Chong Bai,  Is obstructive sleep apnea associated with cardiovascular and all-cause mortality?  Plos One  2013  8(7):e69432. doi:10.1371/journal.pone.00 
    冯净净,胡芸文,宋志刚,揭志军,  呼吸道合胞病毒感染小鼠Th17细胞亚群的变化  中国呼吸与危重监护杂志  2013  12(1):49-54 
    Wei-Feng Pi,, Li-Ping Su,Wei-Guo Xu  Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions  International Journal of Molecular Medicine  2013  32(5):1101-1109 
    Xiao-Jun Guan, Lin Song, Feng-Feng Han,Zhi-Lei Cui, Xi Chen,, Wei-Guo Xu  Mesenchymal Stem Cells Protect Cigarette Smoke-Damaged Lung and Pulmonary Funtion Partly via VEGF-VEGF Receptors  Journal of Cellular Biochemistry  2013  114(2):323-335 
    陈茜,郭雪君,  烟熏法建立的慢性阻塞性肺疾病鼠肺功能和病理的动态变化  中国呼吸与危重监护杂志  2013  33(11):825-829 
    任涟萍,陈光喻,孙晋渊,孙依萍,  红细胞分布宽度对冠脉病变合并阻塞性睡眠呼吸障碍低通气综合征的预测作用  中国呼吸与危重监护杂志  2013  12(4):365-368 
    HAN Feng-feng,YANG Tian-yun,SONG Lin,ZHANG Yue,LI Hui-min,GUAN Wen-bin,?LIU Qian,  Clinical and pathological features and imaging manifestations of bronchial anthracofibrosis: the findings in 15 patients  Chinese Medical Journal  2013  126(14):2641-2645 
    Z-L.CUI, F-F.HAN,X-H. PENG, X.CHEN, C-Y. LUAN, R-C. HAN, W-G. XU and X-J. GUO*  Yes-associated protein 1 promotes adenocarcinoma growth and metastasis through activation of the receptor tyrosine kinase Axl  International Journal of Immunopathology and Pharmacology  2012  25(4):989-1001 
    Ling Yang,Yin-Shi Guo,Jin-Qi Jiang,,Yi-Ping Xu,Ye Tian,Ying Xiong,Li Han  The Effect of Stimuli on Basophil-Mediated Atopic Responses During Asthmatic Lying-In Women and in Newborns  Hybridoma  2012  31(4):255-261 
    周敏,  γ-促分泌酶抑制剂阻断Notch信号对支气管哮喘模型小鼠气道炎症的影响  国际呼吸杂志  2012  32(3):167-171 
    Weifeng Pi,,Liping Su,Weiguo Xu  BMP-2 Up-Regulates PTEN Expression and Induces Apoptosis of Pulmonary Artery Smooth Muscle Cells under Hypoxia  PLoS ONE  2012  7(5)e35283:1-10 
    任莲萍,  CD133+A549肺癌细胞的分选及其肿瘤干细胞和间质化相关基因的表达  上海交通大学学报(医学版)  2012  32 (6):736-738 
    Wen Gu, Weiguo Xu, Tao Ding,  Fringe Controls Na?ve CD4+T Cells Differentiation through Modulating Notch Signaling in Asthmatic Rat Models  PLoS ONE  2012  7(10): e47288. doi:10.1371/journal.pone. 
    丁涛,,顾问,李成业,甘丽杏  哮喘大鼠肺CD4+T细胞Notch1基因启动子甲基化的研究  中国呼吸与危重监护杂志  2011  10 (5):446-450 
    管小俊,宋琳,,徐卫国.   肺内输入骨髓间充质干细胞对肺气肿大鼠慢性炎症的调控  中国呼吸与危重监护杂志  2011  10(6):521-526 
    Song L, Xu JF, Qu JM, Sai Y, Chen CM, Yu L, Li DC,  Linker for activation of T cells A therapeutic role for mesenchymal stem cells in acute lung injury independent of hypoxia-induced mitogenic factor  J Cell Mol Med  2011  16(2):376-385 
    顾问,,丁涛  siRNA干扰Notch信号通路胞外分子β1,3-N-乙酰糖基转移酶对哮喘时T细胞分化的影响  中国呼吸与危重监护杂志  2011  10 (4):321-327 
    , SZ WANG and KS HARROD.  Regulatory T cells and Notch-ligands in RSV infection  Respirology  2011  16(2):67 
    Qian Liu,Wei-Guo Xu,Yong Luo,Feng-Feng Han,Xiao-Hong Yao,Tian-Yun Yang,Yue Zhang, Wei-Feng Pi,and Xue-Jun Guo  Cigarette Smoke Induced Skeletal Muscle Atrophy is Associated with Up-Regulation of USP-19 via p38 and ERK MAPKs  Journal of Cellular Biochemistry  2011  112 (9):2307–2316