• 基本信息
    导师姓名： 张晓玲 学科代码： 100210
    性别： 女 学科名称： 外科学
    培养单位： 附属新华医院 三级学科 骨外
    导师类型： 博士生导师 专业领域名称：
    联系方式： 上海市杨浦区双辽路768号新华医院科研中心二期323室 专业领域代码：
    邮编： 200092 邮箱地址： xlzhang@sibs.ac.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市中西医结合骨质疏松委员会委员（2018-2023）
    国际华人肌骨骼研究学会（International Chinese Musculoskeletal Research Society，ICMRS）理事（2012-2015），女委员会（Woman Committee）主席（2013-2015），中国委员会主席（2019-2021）
    国际矫形与创伤外科学会（SICOT）常委（2014-2020）
    中华医学会骨科分会基础学组委员（2014-2020）
    中国中西医结合学会骨伤科分会委员（2019-2024）
    中国医师协会骨科医师分会委员（2014-2020）
    中国生物材料学会生物材料先进制造分会委员（2016-2020）
    中国生理学会基质生物学专业委员会委员（2016-2020）
    Journal of Orthopaedic Translation国际编委会委员（2013-2020）
    Chinese Journal of Clinicians （International）编委
    中国研究型医院学会运动医学专业委员会委员（2019-2024）
    中国组织工程研究与临床康复杂志编委
    Case Reports in Orthopedic Research（S.Karger AG（瑞士卡尔格）集团期刊，瑞士著名医学和科技出版集团）主编（2017-2022）
    中华关节外科杂志通信编委
    科技部国家科技专家
    教育部学位评议专家
    国家自然基金评审专家
    中国博士后基金评审专家
    中国老年学学会骨质疏松委员会委员（2019-2014）
    上海市科技奖励评审专家
    上海市科学技术专家
    全国卫生产业企业管理协会精准医疗分会常务理事（2019-2024）
    中国研究型医院学会骨科创新与转化专业委员会(COIT)委员/骨科基础研究学组常务委员（2017-2022）
    上海市生物工程学会委员（2018-2023）
    Molecular Therapy （Nature 系列杂志）, Scientific Report, Aging Cell, Current gene therapy, Osteoporosis international, Current drug targets, Plos One, Cytotherapy, Acta Pharmacologica Sinica, Cell Adhesion & Migration, Gene, Acta Biochimica et Biophysica Sinica, Inflammation research, Therapeutic Advances in Musculoskeletal Disease, Clinical and Experimental Immunology等多种国内外专业杂志审稿人
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    2020YFC2002800增龄相关主要器官健康状况的调控和临床干预策略国家重点研发计划项目 2020-07~2023-06 2724万元  课题负责人
    HYZHXM01021空间微重力环境对成体干细胞的生物学效应及关键信号分子研究空间站工程航天医学实验领域项目 2020-01~2023-12 40万元  课题负责人
    201903D321097空间微重力环境对成体干细胞的生物学效应及关键信号分子研究山西省重点研发计划项目 2019-12~2021-11 10万元  课题负责人
    19XD1434100骨关节炎靶向药物研发上海市科技人才计划项目 2019-05~2022-04 40万元  课题负责人
    81830078关节区域免疫微环境特征及影响衰老性骨关节炎退变的机制国家自然科学基金重点项目 2019-01~2023-12 293万元  课题负责人
    81772347IL-12及IL-23调控间充质干细胞介导的骨修复的作用及机制国家自然科学基金面上项目 2018-01~2021-12 55万元  课题负责人
    16430723500PIP5K1β在骨重建中的作用机制及作为骨质疏松治疗靶点的研究上海市科委国际科技合作项目 2016-07~2019-06 30万元  课题负责人
    20161314骨修复材料与机体免疫微环境的相互作用及调节机制上海交通大学医学院高峰高原计划项目 2016-07~2019-06 100万元  课题负责人
    81572123软骨干细胞分化调控及复合温敏性原位成型水凝胶修复关节软骨国家自然科学基金面上项目 2016-01~2019-12 60万元  课题负责人
    14431900900靶向于TNF-α抑制转录因子SATB2成骨机制的骨质疏松药物筛选上海市科委科技支撑项目 2014-07~2017-09 40万元  课题负责人
    2013ZYJB0501膝关节骨关节炎的干预控制研究上海市卫生系统重要疾病联合攻关项目 2014-01~2016-12 250万元  子课题负责人
    13430710700靶向阳离子纳米载体输送DNA及siRNA治疗骨质疏松的研究上海市科委国际科技合作项目 2013-06~2015-06 50万元  课题负责人
    2013SMC-A-6MicroRNA-146 调控骨关节炎软骨退变机制及干预策略上海交通大学晨星青年学者奖励计划SMC-晨星优秀青年教师 A类 2013-01~2015-12 15万元  课题负责人
    12411951100力学负荷下腰椎终板软骨钙化机制的研究及干预新策略上海市科委医学重点项目 2012-10~2015-09 25万元  课题负责人
    11QH1401600Wnt/β-catenin信号在软骨内骨化中的调控上海市科委启明星跟踪计划项目 2011-04~2013-03 15万元  课题负责人
    10SG22骨髓间充质干细胞成骨分化的表观遗传学调控上海市教委（教育发展基金会）曙光计划项目 2011-01~2012-12 15万元  课题负责人
    XDA01030502骨组织构建基础与临床应用中国科学院战略性先导科技专项 2011-01~2015-12 500万元  子课题负责人
    KSCX2-EW-Q-1-07C/EBP-alpha在骨髓间充质干细胞成骨成脂分化中的表观遗传学调控中国科学院知识创新工程重要方向项目 2011-01~2013-12 80万元  课题负责人
    YG2010MS48基于可降解聚精胺纳米基因输送系统的骨再生治疗研究上海交通大学“医工交叉研究基金”项目 2010-06~2012-05 8万元  课题负责人
    2010B065破骨细胞骨吸收关键蛋白Ac45功能研究上海市科委白玉兰项目 2010-06~2011-05 2万元  课题负责人
    1013J3间充质干细胞免疫调节、分化调控的机制及临床应用研究中科院方向性项目 2010-01~2010-12 30万元  课题负责人
    2010CB945600组织干细胞的干性维持、分化控制和免疫调节研究科技部重大研究计划（973） 2010-01~2014-08 2600万元  子课题负责人
    30910369聚合物纳米粒介导 SiRNA 关节基因转移的应用基础研究国家自然基金国际合作 2009-07~2009-12 4万元  课题负责人
    30811120440构筑叶酸靶向非病毒纳米基因输送体系治疗关节炎的研究国家自然科学基金国际(地区)合作交流项目NSFC-CIHR（中加） 2009-01~2011-12 45万元  子课题负责人
    30871435C/EBP-alpha在骨髓间充质干细胞成骨分化中的表观遗传学调控国家自然基金面上项目 2009-01~2011-12 33万元  课题负责人
    08411950400骨关节炎的临床分期标准和阶梯化治疗方案研究上海市科学技术委员会重点科技支撑计划 2008-10~2011-09 25万元  子课题负责人
    08410701800构筑新型靶向阳离子聚合物纳米基因输送体系治疗关节炎的研究上海市科委国际合作项目 2008-09~2010-09 25万元  课题负责人
    30700402去铁胺对BMP2 诱导的骨髓间充质干细胞向成骨细胞分化的调控国家自然科学基金青年项目 2008-01~2010-12 15万元  课题负责人
    07QA14062去铁胺对骨髓间充质干细胞向成骨细胞分化的调控上海市启明星人才基金 2007-09~2009-09 13万元  课题负责人
    04ZR14064IL-1Ra和IL-10联合基因治疗在骨性关节炎中的作用及分子机制上海市科委,自然基金 2004-11~2007-11 5万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Boyi Zhang, Qilai Long, Shanshan Wu, Qixia Xu, Shuling Song, Liu Han, Min Qian, Xiaohui Ren, Hanxin Liu, Jing Jiang, Jianming Guo,, Xing Chang, Qiang Fu*, Eric W-F Lam, Judith Campisi, James L. Kirkland, Yu Sun*.  KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype  Nature Aging  2021  1:454–472 
    Zhu H, Hu Y, Wang C,, He D*.  CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis.   Cell Death Dis.  2020  11(4):284 
    Hu G#, Zhang N#, Li J, Wang J, Wu W, Li J, Tong W, Zhao X, Dai L,  Tumor Necrosis Factor Receptor Associated Factor 3 Modulates Cartilage Degradation through Suppression of Interleukin 17 Signaling.   Am J Pathol  2020  190(8):1701-1712 
    Zhao DY, Jiang WB, Wang Y, Wang CD,, Li QF*, Han D*.  Three-Dimensional-Printed Poly-L-Lactic Acid Scaffolds with Different Pore Sizes Influence Periosteal Distraction Osteogenesis of a Rabbit Skull.  Biomed Res Int.  2020  7381391 
    Xu J, Li J, Hu Y, Dai K, Gan Y, Zhao J, Huang M,  IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders.  Theranostics.  2020  10(9): 3925-3938 
    Shan S#, Fang B#, Zhang Y#, Wang C, Zhou J, Niu C, Gao Y, Zhao D, He J, Wang J,, Li Q*.  Mechanical stretch promotes tumoricidal M1 polarization via the FAK/NF-κB signaling pathway.  FASEB J.  2019  33(12):13254-13266 
    Zhao J, Huang M, Zhang X, Xu J, Hu G, Zhao X, Cui P,  MiR-146a deletion protects from bone loss in OVX mice by suppressing RANKL/OPG and M-CSF in bone microenvironment.  J Bone Miner Res.   2019  jbmr.3832 
    Tong W#, Zeng Y#, Chow DHK, Yeung W, Xu J, Deng Y, Chen S, Zhao H,, Ho KK, Qin L*, Mak KK*.  Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade.  Ann Rheum Dis.  2019  78(4):551-561 
    Huang MJ#, Zhao JY#, Xu JJ, Li J, Zhuang YF,  lncRNA ADAMTS9-AS2 Controls Human Mesenchymal Stem Cell Chondrogenic Differentiation and Functions as a ceRNA.  Mol Ther Nucleic Acids.  2019  18:533-545 
    Geng Y, Zhao X, Xu J, Zhang X, Hu G, Fu SC, Dai K, Chen X, Patrick YS,  Overexpression of mechanical sensitive miR-337-3p alleviates ectopic ossification in rat tendinopathy model via targeting IRS1 and Nox4 of tendon derived stem cells.  J Mol Cell Biol.   2019  pii: mjz030 
    Xu J, Liu J, Gan Y, Dai K, Zhao J, Huang M, Huang Y, Zhuang Y,  High-dose TGF-β1 impairs mesenchymal stem cell-mediated bone regeneration via Bmp2 inhibition.   J Bone Miner Res.  2019  jbmr.3871 
    Liu JL, Li J, Xu JJ, Xiao F, Cui PL, Qiao ZG, Chen XD, Tao WD,  MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via Dual-suppressing RhoA/ROCK1 Signaling Pathway.  Mol Pharmacol.  2019  95(4):451-461 
    Cui P, Zhao X, Liu J, Chen X, Gao Y, Tao K, Wang C*,  miR-146a interacting with lncRNA EPB41L4A-AS1 and lncRNA SNHG7 inhibits proliferation of bone marrow-derived mesenchymal stem cells.  J Cell Physiol.  2019  jcp.29217 
    Zhao X#, Cui P#, Hu G, Wang C, Jiang L, Zhao J, Xu J,  PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation.   J Mol Cell Biol.   2019  pii: mjz028 
    Li D#, Wang H#, Li Z, Wang C, Xiao F, Gao Y, Zhang X, Wang P, Peng J, Cai G, Zuo B, Shen Y, Qi J, Qian N, Deng L, Song W,, Shen L*, Chen X*.  The inhibition of RANKL expression in fibroblasts attenuate CoCr particles induced aseptic prosthesis loosening via the MyD88-independent TLR signaling pathway.  Biochem Biophys Res Commun.  2018  503(2):1115-1122 
    Xiao F#, Wang C#, Wang C#, Gao Y,, Chen X*.  BMPER Enhances Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells.  Cell Physiol Biochem.  2018  45(5):1927-1939 
    Cui Y, Zhao X, Mei L, Pei J, Wang S, Shao Y, Tao Y,, Jiang L*.  Osteon Myospalacem Baileyi attenuates osteoclast differentiation trough RANKL induced NFAT pathways.  J Ethnopharmacol.  2018  213: 65-71 
    Xu Y#, Xu S#, Gao Z, Xiao L, Xiao F, Xu H*,  Degree of endplate chondrocyte degeneration in different tension regions during mechanical stimulation.   Mol Med Rep.  2018  17(3):4415-4421 
    Wang C#, Xiao F#, Gan Y, Yuan W, Zhai Z, Jin T, Chen X,  Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine.  Cell Physiol Biochem.   2018  46(1):133-147 
    Chijian Zuo#, Xiaoying Zhao#, Yu Shi, Wen Wu, Ning Zhang, Jiake Xu, Chuandong Wang, Guoli Hu,  TNF-α inhibits SATB2 expression and osteoblast differentiation through NK-kB and MAPK pathways.  Oncotarget.  2018  9(4):4833-4850 
    Huang M, Zhao J, Huang Y, Dai L,  Meta-analysis of urinary C-terminal telopeptide of type II collagen as a biomarker in osteoarthritis diagnosis.  J Orthop Translat.  2018  13:50-57 
    Li D#, Wang C#, Li Z#, Wang H#, He J, Zhu J, Zhang Y, Shen C, Xiao F, Gao Y, Zhang X, Li Y, Wang P, Peng J, Cai G, Zuo B, Yang Y, Shen Y, Song W,, Shen L*, Chen X*.  Nano-sized Al2O3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts.  Cell Death Dis.  2018  9(8):840 
    Gao Y#, Xiao F#, Wang C, Wang C, Cui P,, Chen X*.  Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells.  J Cell Biochem.  2018  119(8):6986-6996 
    Gao Y#, Xiao F#, Wang C, Wang C, Cui P,, Chen X*.   Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells.  J Cell Biochem.  2018  119(8):6986-6996 
    Wang C#, Xiao F#, Qu X, Zhai Z, Hu G, Chen X#,  Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro.  Front Pharmacol.  2017  8:407 
    Wang C#, Yuan W#, Xiao F#, Gan Y, Zhao X, Zhai Z, Zhao X, Zhao C, Cui P, Jin T, Chen X,  Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration.  Front Pharmacol.   2017  8:572 
    Zhao X, Mei L, Pei J, Liu Z, Shao Y, Tao Y,, Jiang L*.  Sophoridine from Sophora Flower Attenuates Ovariectomy Induced Osteoporosis through the RANKL-ERK-NFAT Pathway.  J Agric Food Chem.   2017  65(44):9647-9654 
    Hu G, Zhao X, Wang C, Geng Y, Zhao J, Xu J, Zuo B, Zhao C, Wang C,  MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4.  Cell Death Dis.  2017  8(10):e3140 
    Wang CL#, Wang H#, Xiao F#, Wang CD, Hu GL, Zhu JF, Shen C, Zuo B, Cui YM, Li D, Gao Y,, Chen XD*.  Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.  Biochem Bioph Res Co.  2017  485(2):400-408 
    Wang C#, Shan S#, Wang C#, Wang J, Li J, Hu G, Dai K, Li Q#,  Mechanical stimulation promote the osteogenic differentiation of bone marrow stromal cells through epigenetic regulation of Sonic Hedgehog.  Exp Cell Res.  2017  352(2):346-356 
    Niu C#, Xiao F#, Yuan K, Hu X, Lin W, Ma R,, Huang Z*.  Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide- Induced Alveolar Bone Resorption.  Front Pharmacol.  2017  8:626 
    Niu C, Yuan K, Ma R, Gao L, Jiang W, Hu X, Lin W,, Huang Z*.  Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway.  Mol Med Rep.  2017  16(4):4879-4886 
    Zhang X#, Wang C#, Zhao J, Xu J, Geng Y, Dai L, Huang Y, Fu S, Dai K*,  miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2.  Cell Death Dis.  2017  8(4):e2734 
    Wang Y, Xu J, Zhang X, Wang C, Huang Y, Dai K*,  TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis.  Cell Death Dis.  2017  8(3):e2715 
    Tao He#, Yan Huang#, Chen Zhang, Denghui Liu, Chao Cheng, Weidong Xu* and Xiaoling Zhang*.  Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis.  Oncotarget.  2017  8(57):96993-97008 
    Huang Y#, Wu C#,, Chang J*, Dai K*.  Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration.  Acta Biomater.   2017  pii: S1742-7061(17)30558-5 
    Jiang L#, Zhao X#, Pei J, Mei L, Cui Y, Wang S, Shao Y,, Tao Y*.  Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways.  J Funct Foods.  2017  37:594-602 
    Xu HG*, Gao Z, Ma MM, Xu JJ, Xiao L, Wang H, Zhang T, Liu X, Xu YM,  P120-catenin mediates intermittent cyclic mechanical tension-induced inflammation in chondrocytes.   J Cell Biochem.  2017  118(12):4508-4516 
    Huang Y#, Wang J#, Yang F, Shao Y,, Dai K*.  Modification and evaluation of micro-nano structured porous bacterial cellulose scaffold for bone tissue engineering.  Mater Sci Eng C Mater Biol Appl.  2017  75:1034-1041 
    Wang CL#, Xiao F#, Wang CD, Zhu JF, Shen C, Zuo B, Wang H, Li D, Wang XY, Feng WJ, Li ZK, Hu GL,, Chen XD*.  Gremlin2 Suppression Increases the BMP-2-Induced Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Via the BMP-2/Smad/Runx2 Signaling Pathway.  J Cell Biochem.  2017  118(2):286-297 
    Wang CD#, Wang J#, Li J, Hu GL, Shan SZ, Li QF* Zhang XL*.   KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis.  Cell Death Dis.  2016  7(8):e2335 
    Xu HG*, Ma MM, Zheng Q, Shen X, Wang H, Zhang SF, Xu JJ, Wang CD,  P120-catenin protects endplate chondrocytes from intermittent cyclic mechanical tension induced degeneration by inhibiting the expression of RhoA/ROCK-1 signaling pathway.   Spine.  2016  41(16):1261-71 
    Wang J#, Wang CD#, Zhang N, Tong WX, Zhang YF, Shan SZ,, Li QF*.  Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1.  Cell Death Dis.  2016  7:e2221 
    Xu HG*, Zheng Q, Song JX, Li J, Wang H, Liu P, Wang J, Wang CD,  Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk.  Osteoarthritis Cartilage.  2016  24(1):158-68 
    Chen D#, Liu Y#, Yang H, Chen D,, Fermandes JC, Chen Y*.  Connexin 43 promotes ossification of the posterior longitudinal ligament through activation of the ERK1/2 and p38 MAPK pathways.  Cell Tissue Res.  2016  363(3):765-73 
    Xu J, Wang Y, Li J, Zhang X, Geng Y, Huang Y, Dai K*,  IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells.  Cell Death Differ.  2016  23(12):1941-1951 
    Tong W, Geng Y, Huang Y, Shi Y, Xiang S, Zhang N, Qin L, Shi Q, Chen Q, Dai K,  In Vivo Identification and Induction of Articular Cartilage Stem cells by Inhibiting NF-κB Signaling in osteoarthritis.  Stem cells.  2015  33(10):3125-37 
    Zhang Y#, Wang J#, Cheng X, Yi B,, Li Q*.  Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway.  Eur J Histochem.  2015  59(2):2467 
    Zuo B#, Zhu JF#, Li J, Wang CD, Zhao XY, Cai GQ, Li Z, Peng J, Wang P, Shen C, Huang Y, Xu J,, Chen XD*.  microRNA-103a functions as a mechno-sensitive microRNA to inhibit bone formation through targeting Runx2.  J Bone Miner Res.  2014  30(2):330-45 
    Du Z, Xiang S, Zang Y, Zhou Y, Wang C, Tang H, Jin T,  Polyspermine imine, a pH Responsive Polycationic siRNA Carrier Degradable to Endogenous Metabolites.  Mol Pharm.  2014  11(10):3300-3306 
    X HG*, Yu YF, Zheng Q, Zhang W, Wang CD, Zhao XY, Tong WX, Wang H, Liu P,  Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification.  Bone.  2014  66():232-239 
    Tong HJ, Liu HQ, Wang YY, Yang F, Shi Q, Fernandes JC, Dai KR,  A novel in vitro system for intracellular delivery of nonviral DNA.  Journal of Orhtopaedic Translation.  2014  2():157-164 
    Wang J, Zhou J, Zhang N,, Li Q*.  A heterocyclic molecule kartogenin induces collagen synthesis of human dermal fibroblasts by activating the smad4/smad5 pathway.  Biochem Biophys Res Commun.  2014  450(1):568-574 
    Huang X, Xu J, Huang M, Li J, Dai L, Dai K*,  Histone deacetylase 1 promotes TGF-β1-mediated early chondrogenesis through down-regulating canonical Wnt signaling.  Biochem Biophys Res Commun.  2014  453(4):810-816 
    Zhao X, Qu Z, Tickner J, Xu J*, Dai K,  The Role of SATB2 in Skeletogenesis and Human Disease.  Cytokine Growth Factor Rev.  2014  25(1):35-44 
    Zhang L, Yang C*, Li J, Zhu Y,  High extracellular magnesium inhibits mineralized matrix deposition and modulates intracellular cacium signaling in human bone marrow-derived mesenchymal stem cells.  Biochem Biophys Res Commun.  2014  450(4):1390-1395 
    He T*, Wu W, Huang Y,, Tang T, Dai K.  Multiple biomarkers analysis for the early detection of prosthetic aseptic loosening of hip arthroplasty.  Int Orthop.  2013  37(6):1025-1031 
    Li J, Zhang N, Huang X, Xu J, Fernandes JC, Dai K*,  Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation.  Cell Death Dis.  2013  4:e832 
    Tong H, Wang C, Huang Y, Shi Q, Fernandes JC, Dai K, Tang G*,  Polyethylenimine600-β-cyclodextrin: a promising nanopolymer for nonviral gene delivery of primary mesenchymal stem cells.  Int J Nanomedicine.  2013  8:1935-46 
    Tang Z, Xie Y*, Yang F, Huang Y, Wang C, Dai K, Zheng X,  Porous Tantalum Coatings Prepared by Vacuum Plasma Spraying Enhance BMSCs Osteogenic differentiation and bone regeneration in vitro and in vivo.  PLoS One.  2013  8(6):e66263 
    Fernandes JC, Qiu X, Winnik FM, Benderdour M,, Dai K, Shi Q*.  Linear polyethylenimine produced by partial acid hydrolysis of poly(2-ethyl-2-oxazoline) for DNA and siRNA delivery in vitro.  Int J Nanomedicine.  2013  8():4091-4102 
    Lui PP, Lee YW, Wong YM,, Dai K, Rolf CG*.  Expression of Wnt pathway mediators in metaplasic tissue in animal model and clinical samples of tendinopathy.   Rheumatology (Oxford)  2013  52(9):1609-1618 
    Xu HG*, Li ZR, Wang H, Liu P, Xiang SN, Wang CD,  Intermittent Cyclic Mechanical Tension-induced Down-regulation of Ectonucleotide Pyrophosphatase Phosphodiesterase 1 Gene Expression is Mainly Dependent on TGF-β1 in End-plate Chondrocytes.  Orthop Surg.  2013  5(1):40-45 
    Xu HG*, Li ZR, Wang H, Liu P, Xiang SN, Wang CD,  Expression of ectonucleotide pyrophosphatase-1 in end-plate chondrocytes with transforming growth factor beta 1 siRNA interference by cyclic mechanical tension.  Chin Med J (Engl)  2013  126(20): 3886-90 
    Cao L, Liu G, Gan Y, Fan Q, Yang F,, Tang T, Dai K*.  The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats.  Biomaterials.  2012  33(20):5076-84 
    Zuo C, Huang Y, Bajis R, Sahih M, Li YP, Dai K,  Osteoblastogenesis regulation signals in bone remodeling  Osteoporos Int.  2012  23(6):1653-63 
    Xiang S#, Su J#, Tong H, Yang F, Tong W, Yuan W, Wu F, Wang C, Jin T*, Dai K,  Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy.  Biomaterials.  2012  33(27):6520-32 
    Xu HG*, Zhang XH, Wang H, Liu P, Wang LT, Zuo CJ, Tong WX,  Intermittent Cyclic Mechanical Tension (ICMT) Induced Calcification and Down-regulation of ankh Gene Expression of End-plate Chondrocytes.  Spine.  2012  37(14):1192-7 
    Shi Y#, Fu Y#, Tong W, Geng Y, Lui PP, Tang T,, Dai K*.  Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway.  J Cell Biochem.  2012  113(10):3133-42 
    Wu Y,, Zhang P, Fang B*, Jiang L.  Intermittent Traction Stretch Promotes the Osteoblastic Differentiation of Bone Mesenchymal Stem Cells by the ERK1/2-Activated Cbfa1 Pathway.  Connect Tissue Res.  2012  53(6):451-459 
    Xiang S, Tong H, Shi Q, Fernandes JC, Jin T, Dai K,  Uptake mechanisms of non-viral gene delivery.  J Control Release.  2012  158(3):371-8 
    Huang Y,, Du K, Yang F, Shi Y, Huang J, Tang T, Chen D, Dai K*.  Inhibition of β-catenin signaling in chondrocytes induces delayed fracture healing in mice.   J Orthop Res.  2012  30(2):304-10 
    Li J, Huang J, Dai L, Yu D, Chen Q,, Dai K*.   MiR-146a, an interleukin-1beta responsive microRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4.  Arthritis Res Ther.  2012  14(2):R75 
    Fernandes JC, Qiu X, Winnik FM, Benderdour M,, Dai K, Shi Q*.  Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: optimization studies.  Int J Nanomedicine.   2012  7():5833-5845 
    Li X,, Shen G, Tang G*.  Effects of tensile forces on serum deprivation-induced osteoblast apoptosis: expression analysis of caspases, Bcl-2, and Bax.  Chin Med J (Engl).  2012  125(14):2568-2573 
    Jreyssaty C, Shi Q*, Wang H, Qiu X, Winnik FM,, Dai K, Benderdour M, Fernandes JC.  Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles In Vitro.  ISRN Pharm.  2012  2012:369270 
    Shi Y, Li H,, Fu Y, Huang Y, Lui PP, Tang T, Dai K*.  Continuous cyclic mechanical tension inhibited Runx2 expression in mesenchymal stem cells through RhoA-ERK1/2 pathway.   J Cell Physiol.  2011  226(8):2159-69 
    Lin Z#, Solomon KL#,, Pavlos NJ, Abel T, Willers C, Dai K, Xu J, Zheng Q*, Zheng M*.  In vitro evaluation of natural marine sponge collagen as a scaffold for bone tissue engineering.  Int J Biol Sci.  2011  7(7):968-77 
    Shi Q*, Wang H, Tran C, Qiu X, Winnik FM,, Dai K, Benderdour M, Fernandes JC.  Hydrodynamic delivery of chitosan-folate-DNA nanoparticles in rats with adjuvant-induced arthritis.  J Biomed Biotechnol.  2011  2011:148763 
    Shi Q,, Dai KR, Benderdour M, Fernandes JC*.  siRNA therapy for cancer and non-lethal diseases such as arthritis and osteoporosis.  Expert Opin Biol Ther.  2011  11(1):5-16 
    Yang F, Xie Y, Li H, Tang T,, Gan Y, Zheng X*, Dai K*.  Human bone marrow-derived stromal cells cultured with a plasma sprayed CaO-ZrO2-SiO2 coating.  J Biomed Mater Res B Appl Biomater.  2010  95(1):192-201 
    Yang C, Yuan G, Zhang J, Tang Z,, Dai K*.  Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation.   Biomed Mater.  2010  5(4):045005 
    , Tang T, Shi Q, Fernandes JC, Dai K*.   The immunologic properties of undifferentiated and osteogenic differentiated mouse mesenchymal stem cells and its potential application in bone regeneration.  Immunobiology.  2009  214(3):179-86 
    Huang Y#, Jin X#,, Sun H, Tu J, Tang T, Chang J*, Dai K*.   In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration  Biomaterials.  2009  30(28):5041-8 
    Zhu J,, Wang C, Peng X, Zhang X*.  Periprosthetic strain magnitude-dependent upregulation of type I collagen synthesis in human osteoblasts through an ERK1/2 pathway.  Int Orthop.  2009  33(5):1455-60 
    Fan Q, Tang T,, Dai K*.   The role of CCAAT/enhancer binding protein (C/EBP) alpha in osteogenesis of C3H10T1/2 cells induced by BMP-2.  J Cell Mol Med .  2009  13(8B):2489-505 
    Tong H, Qin S, Fernandes JC, Li L, Dai K,  Progress and prospects of chitosan and its derivatives as non-viral gene vectors in gene therapy.   Curr Gene Ther.  2009  9(6):495-502 
    Hou H,, Tang T, Dai K*, Ge R.  Enhancement of bone formation by genetically-engineered bone marrow stromal cells expressing BMP-2, VEGF and angiopoietin-1.   Biotechnol Lett.  2009  31(8):1183-9 
    Sun H, Dai K*, Tang T,  Regulation of osteoblast differentiation by slit2 in osteoblastic cells.  Cells Tissues Organs.  2009  190(2):69-80 
    Tu J#, Wang H#, Li H, Dai K, Wang J*,  The in vivo bone formation by mesenchymal stem cells in zein scaffolds.  Biomaterials  2009  30(26):4369-76 
    Zhang P, Han D, Tang T,, Dai K*.  The destruction evaluation in different foot joints: new ideas in collagen-induced arthritis rat model.   Rheumatol Int.  2009  29(6):607-13 
    Han D, Sun X,, Tang T, Dai K*.   Ectopic osteogenesis by ex vivo gene therapy using beta tricalcium phosphate as a carrier.  Connect Tissue Res.  2008  49(5):343-50 
    Zhang P, Han D, Tang T,, Dai K*.  Inhibition of the Development of Collagen-Induced Arthritis in Wistar Rats through Vagus Nerve Suspension: A 3-month Observation.   Inflamm Res.  2008  57(7):322-8 
    Zhang C, Tang T, Ren W,, Dai K*.   Influence of mouse genetic background on wear particle-induced in vivo inflammatory osteolysis.   Inflamm Res.  2008  57(5):211-5 
    Dai KR,, Shi Q, Fernandes JC*.   Gene therapy of arthritis and orthopaedic disorders: current experimental approaches in China and in Canada.  Expert Opin Biol Ther.  2008  8(9):1337-46 
    Fernandes JC, Wang H, Jreyssaty C, Benderdour M, Lavigne P, Qiu X, Winnik FM,, Dai K, Shi Q*.  Bone-protective effects of nonviral gene therapy with folate-chitosan DNA nanoparticle containing interleukin-1 receptor antagonist gene in rats with adjuvant-induced arthritis.  Mol Ther.  2008  2008 Jul;16(7):1243-51 
    Qu ZH,, Tang TT, Dai KR*.  Promotion of osteogenesis through beta-catenin signaling by desferrioxamine.  Biochem Biophys Res Commun.  2008  370(2):332-7 
    Qu ZH, Wang HJ, Tang TT,, Wang JY, Dai KR*.  Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation.  Acta Biomater.  2008  4(5):1360-8 
    , Zhang C, Tang T, Qu Z, Lou J, Dai K*.  Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and   J Orthop Res.  2008  26(3):314-21 
    Sun X, Gan Y, Tang T,, Dai K*.   In vitro proliferation and differentiation of human mesenchymal stem cells cultured in autologous plasma derived from bone marrow.   Tissue Eng Part A.  2008  14(3):391-400 
    Li H, Dai K*, Tang T,, Yan M, Lou J.   Bone regeneration by implantation of adipose-derived stromal cells expressing BMP-2.  Biochem Biophys Res Commun.  2007  356(4):836-42 
    Zhang C, Tang TT, Ren WP,, Dai KR*.  Inhibiting wear particles-induced osteolysis with doxycycline.  Acta Pharmacol Sin.  2007  28(10):1603-10 
    , Yu C, Xushi, Zhang C, Tang T, Dai K.  Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo.   Biochem Biophys Res Commun.  2006  341(1):202-8 
    Dai KR*, Xu XL, Tang TT, Zhu ZA, Yu CF, Lou JR,  Repairing of goat tibial bone defects with BMP-2 gene-modified tissue-engineered bone.   Calcif Tissue Int.  2005  77(1):55-61 
    Yue, B, Lu,, Dai, KR, Zhang, XL, Yu, CF, Lou, JR, Tang, TT*.  BMP2 gene therapy on the repair of bone defects of aged rats.  Calcif Tissue Int.  2005  77(6): 395-403 
    , Mao Z, Yu C*.  Suppression of early experimental osteoarthritis by gene transfer of interleukin 1 receptor antagonist and interleukin 10.   Journal of Orthopaedic Research.  2004  22(4):742-750