- 基本信息
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导师姓名：
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张爱军
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学科代码：
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100211
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性别：
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男
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学科名称：
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妇产科学
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培养单位：
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附属瑞金医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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专业领域代码：
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邮编：
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邮箱地址：
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zhaj1268@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海市中西医学会生殖医学专业委员会副主任委员
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中国性学会生殖医学专业委员会委员
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中华医学会生殖医学分会青年委员
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中国医师协会男科学分会男性生殖医学专家委员会委员
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上海基因健康专家委员会常务委员
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中国医疗保健国际交流促进会生殖医学分会委员
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上海市中西医结合学会生殖医学专业委员实验学组组长
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中国医药教育协会生殖内分泌专业委员会委员
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中华医学会生殖医学分会实验室管理学组委员
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基因健康专业委员会常务委员
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中国医师协会生殖医学专业委员会委员
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《诊断学理论与实践》杂志编委
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《中华生殖与避孕》杂志编委
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《Journal of Assisted Reproduction and Genetics》、《中华临床医师杂志》、《上海交通大学学报（医学版）》杂志审稿专家
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- 科研项目
| 82071596 | CDYL/Kisspeptin/KISS1R信号通路异常致卵巢储备功能下降的机制研究 | 国家自然科学基金面上项目 |
2021-01~2024-12
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55万元
| 课题负责人 |
| SHDC2020CR1008A | 阴道用乳酸杆菌胶囊预处理改善菌群失调的PCOS患者FET结局的多中心随机对照研究 | 申康重大临床研究项目 |
2020-10~2022-09
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100万元
| 子课题负责人 |
| / | 滋肾育胎丸在提高POI患者IVF临床妊娠率中作用的前瞻性、多中心、随机、平行对照研究 | 横向课题临床研究 |
2019-12~2022-12
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48万元
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| 81873857 | CD44/c-Src调控PECAM1低表达影响反复着床失败患者子宫内膜容受性的分子机制 | 国家自然科学基金面上项目 |
2019-01~2022-12
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57万元
| 课题负责人 |
| YG2017ZD11 | 自体生殖干细胞线粒体移植在改善人 | 多学科交叉培育（医工） |
2018-01~2020-12
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75万元
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| SHDC12015122 | 无精子症生育力重建：精子获取与冻融 | 上海申康发展中心 |
2016-01~2018-12
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80万元
| 子课题负责人 |
| 81370763 | ASH1L和JMJD3在人卵子成熟和种植前胚胎发育中的作用及调控机制 | 国家自然科学基金 |
2014-01~2017-12
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70万元
| 课题负责人 |
| 11ZR1422700 | 人颗粒细胞对卵子体外成熟及发育相关miRNA与组蛋白甲基化的影响 | 上海市科委自然科学基金 |
2011-01~2013-12
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10万元
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| 2010266 | 促排卵周期中人未成熟卵子发育潜能与组蛋白甲基化状态的研究 | 上海市卫生局 |
2011-01~2012-12
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3万元
| 课题负责人 |
| 04ZR14103 | PGD应用于Y染色体微缺失在家系中垂直传播的初探研究 | 上海市科委自然科学基金 |
2005-01~2007-12
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5万元
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- 学术论文
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Dan Zhang, Mi Han, Mingjuan Zhou, Mengyu Liu, Yan Li, Bufang Xu,
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Down-regulation of S100P induces apoptosis in endometrial epithelial cell during GnRH antagonist protocol
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Reprod Biol Endocrinol.
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2021
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2;19(1):99.
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Yan Li, Dan Zhang, Bailing Jin, Lan Xia,
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Proteomic Analysis of Uterine Tissues During Peri-Implantation Period in Mice with Experimentally Induced Adenomyosis that Treated with anti-Ngf: Implications for Cell-Cell Adhesion and Metabolic Processes
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Reprod Sci.
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2021
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28(1):207-217
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Chen Q, Zhou XW, Zhang AJ,
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ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma.
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J Exp Clin Cancer Res
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2021
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7;40(1):23.
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Xiaowei Zhou, Bufang Xu, Dan Zhang, Xiaoping Jiang, Peter C. K. Leung, Xiaoyu Xia,
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Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity
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Front Cell Dev Biol.
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2020
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8：105
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Qian Chen,Ying Ni,Mi Han,Wen-Jie Zhou,
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Integrin-linked kinase improves uterine receptivity formation by activating Wnt/β-catenin signaling and up-regulating MMP-3/9 expression
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Am J Transl Res.
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2020
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12(6):3011-3022
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Qian Chen,Yong Fan, Xiaowei Zhou, Zheng Yan, YanPing Kuang*,, Chen Xu*
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GnRH antagonist alters the migration of endometrial epithelial cells by reducing CKB
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Reproduction
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2020
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159(6):733-743
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Bufang Xu, Mingjuan Zhou, Meiyu Cheng, Dan Zhang, Xian Wu, Chenchen Si, Lan Xia, Huihui Xu, Jian Li, Hsun-Ming Chang,, Aijun Zhang
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Transvaginal ovarian drilling followed by controlled ovarian stimulation from the next day improves ovarian response for the poor responders with polycystic ovary yndrome during IVF treatment: A pilot study
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Reprod Biol Endocrinol.
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2020
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24;18(1):7.
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Xiaobin Zhu, Ying Ni, Meiyu Cheng, Qian Chen,
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Evaluation of a fluorescence flow cytometry reagent for anti-Müllerian hormone detection
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Acta Biochim Biophys Sin (Shanghai).
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2020
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29;52(12):1427-1429.
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Xia L, Zhao S, Xu H, Wu X,, Niu Z.
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Miscarriage rate is high with frozen-thawed blastocysts arising from poor-quality cleavage stage embryos
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ront Endocrinol (Lausanne)
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2020
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16;11:561085.
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Mingjuan Zhou, Huihui Xu, Dan Zhang, Chenchen Si, Xiaowei Zhou , Hui Zhao, Qiang Liu, Bufang Xu,
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Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization
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J Adv Res.
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2020
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9;30:15-25
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Xiao-Bin Zhu, Qian Chen, Wei-Min Fan, Zhi-Hong Niu, Bu-Fang Xu ,
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Sperm DNA fragmentation in Chinese couples with unexplained recurrent pregnancy loss
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Asian J Androl
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2020
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22(3):296-301.
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Huihui Xu, Mingjuan Zhou, Yi Cao, Dan Zhang, Mi Han, Xinxing
Gao, Bufang Xu,
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Genome-wide analysis of long noncoding RNAs, microRNAs, and mRNAs forming a competing endogenous RNA network in repeated implantation failure
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Gene
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2019
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/
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Dan Zhang, Lan Xia, Huihui Xu, Qian Chen, Bailing Jin,
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Flexible Low-Dose GnRH Antagonist Protocol Is Effective in Patients With Sufficient Ovarian Reserve in IVF
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Frontiers in Endocrinology
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2019
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9:767-7
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Xiaoyu Xia#, Xiaowei Zhou#, Yanmei Quan#, Yanqin Hu, Fengying Xing, Zhengzheng Li, Bufang Xu*, Chen Xu* and Aijun Zhang*
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Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice
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Cell Death and Disease
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2019
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10:229-13
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Wen-Jie Zhou, Jie Zhang, Hui-Li Yang, Ke Wu, Feng Xie, Jiang-Nan Wu, Yan Wang, Li Yao, Yan Zhuang,Jiang-Dong Xiang,, Yin-Yan He* and Ming-Qing Li*
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Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism
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Cell Communication and Signaling
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2019
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17:99-15
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Jin Bailing, Niu Zhihong, Xu Bufang, Chen Qian,
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comparison of clinical outcomes among dual ovarian stimulation, mild stimulation and luteal phase stimulation protocols in women with poor ovarian response
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Gynecol Endocrinol
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2018
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34(8) :694-697
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F Guo, C Si, M Zhou, J Wang, D Zhang, Leung PCK, B Xu,
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Decreased PECAM1-mediated TGF-β1 expression in the mid-secretory endometrium in women with recurrent implantation failure
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《Human Reproduction》
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2018
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33 (5) :832-843
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B Xu, M Zhou, J Wang, D Zhang, F Guo, Si C, Leung PCK,
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Increased AIF-1-mediated TNF-α expression during implantation phase in IVF cycles with GnRH antagonist protocol
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《Human Reproduction》
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2018
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33 (7):1270-1280
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Bufang Xu, Jingwen Wang, Lan Xia, Dan Zhang, Xian Wu,
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GnRH antagonist negatively affects endometrial receptivity in in vitro fertilization (IVF) cycles, however, its underlying mechanism remains unclear.
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《Scientific Reports》
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2017
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3(7):39912
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N.Zhihong,F.Yun,Z.Pinggui,Z.Sulian,
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Cytokine profiling in the Eutopin Endometrium of Adenomyosis During the Implantation Window after Ovarian Stimulation
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Reproductive Sciences
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2016
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23(1):124-133
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李雁,叶瑶,徐步芳,
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抗神经生长隐私抗体用于改善子宫腺肌病小鼠宫腔内环境的研究
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生殖与避孕
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2015
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35(6):353-358
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Qian Chen,,Feng Yu,Jing Gao,Yue Liu,Chenli Yu,Xu Zhou,Chen Xu
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Label-Free Proteomics Uncovers Energy Metabolism and Focal Adhesion Regulations Responsive for Endometrium Receptivity
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proteome research
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2015
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14,1831-1842
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Bu-fang Xu,Guang-yan Wang,Wei-min Fan,Qian Chen,
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Which is the Best Protocol of Ovarian Stimulation Prior to Artificial Insemination by Donor Sperm. Journal of Reproduction & Contraception
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Journal of Reproduction & Contraception
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2014
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25(1):41-48
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Ling Wu, Bufang Xu, Weimin Fan, Xiaobin Zhu, Guangyan Wang,,
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Adiponectin protects Leydig cells against pro-inflammatory cytokines by suppressing the nuclear factor-kappaB signaling pathway
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FEBS Journal
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2013
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280(16):3920-7
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Wu L,, Sun Y, Zhu X, Fan W, Lu X, Yang Q, Feng Y
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Sirt1 exerts anti-inflammatory effects and promotes steroidogenesis in Leydig cells
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Fertil Steril
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2012
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98(1):194-9
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, Bufang Xu, Yijuan Sun, Xiaowei Lu, Ruihuan Gu, Qian Chen, Yun Feng, Chen Xu
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The effect of human cumulus cells on the maturation and developmental potential of immature oocytes in ICSI cycles.
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J Assist Reprod Genet
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2012
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29:313-9
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朱晓斌,冯云,吴玲,樊卫民,陆小溦,孙贻娟,谷瑞环,
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自精保存在辅助生殖技术中的意义
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中国优生与遗传杂志
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2012
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20(3):118-9
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Bufang Xu, Xiaoxi Sun, Lu Li, Ling Wu,, Yun Feng
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Pinopodes, leukemia inhibitory factor, integrin-b3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss
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Fertil Steril
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2012
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98(2):389-95
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朱晓斌,冯云,杨青青,陆小溦,樊卫民,吴铃,李志超,
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染色体异常对IVF-ET妊娠结局的影响
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中国男科学杂志
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2012
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26(10):29-32
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Sun Y, Feng Y,, Lu X, Niu Z, Gu R
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Frozen-thawed embryo transfer cycles in China: clinical outcomes of two and three multicellular embryos transfers
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J Assist Reprod Genet
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2012
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29(5):417-21
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, Bufang Xu, Yijuan Sun, Xiaowei Lu, Ruihuan Gu, Ling Wu, Yun Feng, Chen Xu
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Dynamic changes of histone H3 trimethylated at positions K4 and K27 in human oocytes and pre-implantation embryos
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Fertil Steril
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2012
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98(4):1009-16
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徐步芳, 孙贻娟,陆小溦,朱晓斌,冯云,
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精子DNA碎片率对常规体外受精-胚胎移植结局的影响
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中国男科学杂志
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2011
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25(8):23-26
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谷瑞环,孙贻娟,陆小溦,冯云,
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第二极体排出时间在预测体外受精结局中的价值
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中华临床医师杂志
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2011
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5(14):4127-32
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徐步芳,冯云,王枫钊,牛志宏,陈骞,
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胚胎移植日子宫内膜运动波对冻融胚胎移植周期妊娠结局的预测价值
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中华临床医师杂志
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2011
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5(14):32-5
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朱晓斌, 冯云, 纪冬梅, 刘建兵, 徐步芳,
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Y染色体微缺失检测及生激素水平研究在非梗阻性无精子症患者睾丸穿刺中的意义
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中国男科学杂志
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2010
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24(2):35-38
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纪冬梅, 冯云, 李铮, 朱晓斌,
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810例严重少（无）精子症患者Y染色体微缺失筛查与分析
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中国优生与遗传杂志
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2010
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18(2):36-38
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Qian CHEN,, Yun FENG, Xiao-wei LU, Dong-mei JI, Zhi-peng XU
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Effect of the P1 Medium and the ECM Medium on Embryo
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Journal of Reproduction & Contraception
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2009
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20(2):22-7
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孙贻娟,,冯 云, 张慧琴,牛志宏,陆小溦
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不同胚胎选择体系对体外受精-胚胎移植妊娠结局的影响
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生 殖 与 避 孕
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2009
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29(1):26-30
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Niu Z, Feng Y,, Sun Y, Zhang H
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Progesterone levels on oocyte retrieval day can predict the quantity of viable embryos but not pregnancy outcome of intracytoplasmic sperm injection
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Gynecol Endocrinol
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2008
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24(8):452-8
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李雁, 冯云, 孙贻娟, 牛志宏,
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人卵母细胞与体细胞的电融合效率
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上海交通大学学报( 医学版)
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2007
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27:837-840
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