- 基本信息
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导师姓名：
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刘勇
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学科代码：
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100214
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性别：
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男
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学科名称：
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肿瘤学
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培养单位：
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附属第一人民医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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肿瘤学 专业学位
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联系方式：
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上海市虹口区海宁路100号上海市第一人民医院肿瘤放疗科
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专业领域代码：
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105121
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邮编：
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200080
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邮箱地址：
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drliuyrt@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海市抗癌协会放射治疗专委会常委
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上海市科学技术专家库成员
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日本放射线肿瘤学会会员(JASTRO)
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中华医学会放射治疗分会学组委员
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上海市医师协会肿瘤放疗科医师分会委员
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上海市学位委员会论文评审专家
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教育部学位与研究生教育发展中心论文评审专家
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上海医学会肿瘤放射治疗专科青委会副主任委员
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日本放射线影响学会会员(JRR)
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上海市核学会肿瘤放疗与影像专委会副主任委员
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- 科研项目
| 2022XD039 | 上海市卫生健康学科带头人计划 | 上海市卫健委 |
2023-01~2025-12
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45万元
| 课题负责人 |
| 82073478 | 维生素D通过Nrf2减少程序性坏死缓解放射性直肠损伤的机制研究 | 国家自然科学基金 |
2021-01~2024-12
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56万元
| 课题负责人 |
| SHDC12019X03 | 基于调强局部同期加量的脑转移放疗研究 | 上海申康中心 |
2019-12~2022-11
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30万元
| 课题负责人 |
| 19411950903 | 国产化同步加速器的质子治疗装置对胰腺癌放射生物影响的研究 | 上海市科委 |
2019-09~2022-06
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30万元
| 课题负责人 |
| 81872547 | 外泌体miR-122-5p在乏氧促进的放射性直肠损伤中的作用及机制研究 | 国家自然科学基金 |
2019-01~2022-12
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57万元
| 课题负责人 |
| 20181713 | 精准放射治疗及其转化研究 | 上海交大医学院高峰高原“双百人计划” |
2018-09~2021-10
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100万元
| 课题负责人 |
| 18ZR1430800 | 外泌体miR-122-5p在乏氧促进的放射性直肠损伤中的作用及机制研究 | 上海市自然科学基金 |
2018-05~2021-04
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20万元
| 课题负责人 |
| 2018 | “卓越医师”计划 | 上海市第一人民医院 |
2018-01~2019-12
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8万元
| 课题负责人 |
| YG2016MS24 | 纳米材料靶向乏氧细胞增敏放疗抑制鼻咽癌转移的应用技术研究 | 上海交大医工交叉研究基金 |
2017-01~2019-12
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21万元
| 课题负责人 |
| 040517-02004 | 端粒酶逆转录酶对放射性直肠损伤的影响与机制的研究 | 上海市第一人民医院临床重点专科基金 |
2016-01~2018-12
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50万元
| 课题负责人 |
| 31370838 | 乏氧诱导的MiR-210对放射性直肠纤维化的影响与机制研究 | 国家自然科学基金 |
2014-01~2017-12
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80万元
| 课题负责人 |
| 13PJ1401600 | 端粒酶逆转录酶对放射性直肠纤维化的影响与机制的研究 | 上海市浦江人才 |
2013-09~2015-08
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20万元
| 课题负责人 |
| N130204 | 血管内皮生长因子通路相关的血管调节对于盆腔肿瘤放射抑制效果和直肠损伤的影响 | 教育部留学归国基金 |
2013-08~2016-07
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3万元
| 课题负责人 |
| 81202148 | 端粒酶逆转录酶对放射性直肠纤维化的影响与机制的研究 | 国家自然科学基金 |
2013-01~2015-12
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23万元
| 课题负责人 |
| 20114Y157 | 血浆游离DNA检测在直肠癌个体化放疗中的应用 | 上海市卫生局科研基金 |
2012-01~2014-12
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2万元
| 课题负责人 |
| 985IIIYPT06 | 质子重离子生物学效应评估用放射生物学研究平台建设 | 复旦大学“985工程”三期放射医学研究 |
2011-01~2013-12
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40万元
| 子课题负责人 |
| 22791188 | 血管增生抑制剂，伽玛线照射的并用对于肿瘤内硼素化合物分布的影响的研究 | 日本文部省，日本学术振兴会 |
2010-06~2011-01
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10万元
| 课题负责人 |
- 学术论文
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Ziyu Le#,Dongmei Wu#,Xuming Chen#,Lei Wang,Yi Xu,Guoqi Zhao,Chengxiu Zhang,Ying Chen,Ye Hu,Shengyu Yao,Tingfeng Chen,Jiangping Ren*,Guang Yang*,
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A radiomics approach for predicting acute hematologic toxicity in patients with cervical or endometrial cancer undergoing external-beam radiotherapy
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Radiotherapy and Oncology
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2023
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on line
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Changchang Zhang#,Wenzhi Tu#,Xuming Chen,Bing Xu,Xin Li,Chaolei Hu,Mingwu Shen,Shaoli Song,Chunjuan Jiang,Shengyu Yao,Andrij Pich*,,Xiangyang Shi*
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Intelligent design of polymer nanogels for full-process sensitized radiotherapy and dual-mode computed tomography/magnetic resonance imaging of tumors
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Theranostics
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2022
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12(7): 3420-3437
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Nuo Yu#,Wenzhi Tu#,Pu Qiu,Qian Ren,Xuming Chen,Meifang Zhu,,Zhigang Chen*
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Full-route advances via biomimetic and biodegradable ultrasmall-innano architectures with radiation-photo synergy
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Nano Today
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2022
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43,101427
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Huanliang Chen#,Wenzhi Tu#,Yue Lu#,Yingzi Zhang,Yiqing Xu,Xuming Chen,Meiling Zhu*,
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Low-dose X-ray irradiation combined with FAK inhibitors improves the immune microenvironment and confers sensitivity to radiotherapy in pancreatic cancer
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Biomedicine & Pharmacotherapy
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2022
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151,113114
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Yiqing Xu#,Wenzhi Tu#,Di Sun,Xuming Chen,Yulong Ge,Shengyu Yao,Bing Li*,Zhenbo Zhang*,
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Nrf2 alleviates radiation-induced rectal injury by inhibiting of necroptosis
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Biochemical and Biophysical Research Communications
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2021
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554C:49-55
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Xuming Chen#, Shanlin Sun#, Narisu Bai#, Kun Han#, Qianqian Liu, Shengyu Yao, Hao Tang, Chupeng Zhang, Zhipeng Lu, Qian Huang, Guoqi Zhao, Yi Xu, Tingfeng Chen, Xiaohui Xie*,
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A deep learning-based auto-segmentation system for organs-at-risk on whole-body computed tomography images for radiation therapy
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Radiotherapy and Oncology
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2021
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160:175-184
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Yunchao Xiao#,Yu Fan#,Wenzhi Tu,Yuesheng Ning,Meifang Zhu,, Xiangyang Shi*
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Multifunctional PLGA Microfibrous Rings Enable MR Imaging-Guided Tumor Chemotherapy and Metastasis Inhibition Through Prevention of Circulating Tumor Cell Shedding
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Nano Taday
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2021
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38:101123
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Yulong Ge#,Wenzhi Tu#,Junjun Li,Xuming Chen,Ying
Chen,Yi Xu,Yiqing Xu,Yaming Wang*,
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MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1
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Toxicology and Applied Pharmacology
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2020
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399:115054
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Yu Fan#,Wenzhi Tu#,Mingwu Shen,Xuming Chen,Yuesheng Ning, Junjun Li,Tingfeng Chen,Han Wang,Fangfang Yin,,Xiangyang Shi*
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Targeted Tumor Hypoxia Dual-Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer-Based Nanosensitizers
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Advanced Functional Materials
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2020
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30(13):1909285
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Shengyu Yao#,Yin Zhang,Tingfeng Chen,Guoqi Zhao,Zhekai Hu, Xiaokai Lu,
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Dosimetric Comparison Between Jaw Tracking and No Jaw Tracking in Intensity-Modulated Radiation Therapy
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Technology in Cancer Research &Treatment
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2019
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18:1-6
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Hao Tang#, Xuming Chen#, Yang Liu, Zhipeng Lu, Junhua You, Mingzhou Yang, Shengyu Yao, Guoqi Zhao, Yi Xu, Tingfeng Chen,, Xiaohui Xie*
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Clinically applicable deep learning framework for organs at risk delineation in CT images
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Nature Machine Intelligence
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2019
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1:480–491
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Jun-Jun Li#, Wen-Zhi Tu#, Xu-Ming Chen, Hou-Yu Ying, Ying Chen, Yu-Long Ge, Jing Wang, Yi Xu, Ting-Feng Chen, Xiao-Wei Zhang, Jin-Jun Ye*,
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FAK alleviates radiation-induced rectal injury by decreasing apoptosis
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Toxicology and Applied Pharmacology
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2018
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360:131-140
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乐紫妤#,
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体部立体定向放疗的放射生物学研究进展
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中华放射肿瘤学杂志
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2018
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27 (9): 864-868
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葛玉龙#,涂文志,
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质子肿瘤放射生物学的研究进展
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中华放射肿瘤学杂志
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2018
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27(8): 784-788
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, G Zhao, Y Xu, T Zhang, Z Chen, G Yan, W Tu, Y Hu, Y Chen, X He, X Li, H Chen, S Yao, Z Hu, X Chen, T Chen*
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Phase II study of adjuvant chemo-radiotherapy using docetaxel/cisplatin/5-fluorouracil before and after intensity-modulated radiotherapy with concurrent docetaxel in patients with completely (R0) resected gastric carcinoma
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Am. J. Clin. Oncol.
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2018
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41(7):619-625
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Z Le#, X Niu, Y Chen, X Ou, G Zhao, Q Liu, W Tu,
C Hu, L Kong*,
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Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy
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Oncotarget
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2017
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8(38):63026-63037
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, G Zhao, Y Xu, X He, X Li, H Chen, Q Wu, S Yao, G Yan, T Chen*
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Multicenter phase II study of peri-irradiation chemotherapy plus intensity-modulated radiotherapy with concurrent weekly docetaxel for inoperable or medically unresectable nonmetastatic gastric cancer
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Int. J. Radiat. Oncol. Biol. Phys.
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2017
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98:1096-1105
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Q Liu#, Y Sun, Y Lv, Z Le, Y Xin, P Zhang,
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TERT alleviates irradiation-induced late rectal injury by reducing hypoxia-induced ROS levels through the activation of NF-κB and autophagy
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Int. J. Mol. Med.
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2016
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38:785-793
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Liu Y#,, Bu W*, Xiao Q, Sun Y, Zhao K, Fan W, Liu J, Shi J*
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Radiation-/hypoxia-induced solid tumor metastasis and regrowth inhibited by hypoxia-specific upconversion nanoradiosensitizer
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Biomaterials
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2015
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49:1-8.
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乐紫妤#,
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重离子肿瘤放射生物学的研究进展
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中华放射肿瘤学杂志
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2015
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24: 600-604
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Sun Y#, Xing X#, Liu Q, Wang Z, Xin Y, Zhang P, Hu C*,
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Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1α/miR-210/Bcl-2 pathway in colon cancer cells
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Int. J. Oncol.
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2015
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46:750-6.
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Sun W#, Sun Y#, Zhu M, Wang Z, Zhang H, Xin Y, Jiang G, Guo X, Zhang Z*,
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The role of plasma cell-free DNA detection in predicting preoperative chemoradiotherapy response in rectal cancer patients
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Oncol. Rep.
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2014
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31: 1466-1472
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Liu J#,, Bu W*, Bu J, Sun Y, Du J, Shi J*.
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Ultrasensitive nanosensors based on upconversion nanoparticles for selective hypoxia imaging in vivo upon near-infrared excitation
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J. Am. Chem. Soc.
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2014
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136:9701-9
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, Suzuki M, Masunaga S, Chen YW, Kashino G, Tanaka H, Sakurai Y, Kirihata M, Ono K*
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Effect of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor.
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J. Radiat. Res.
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2013
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54: 260-267
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,陈一瑋,小野公二,蒋国梁
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细胞水平的放疗：硼中子俘获疗法介绍
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中华临床医师杂志
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2011
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5: 6699-6702
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