• 基本信息
    导师姓名: 孙晓建 专业代码: 071000
    性别: 专业名称: 生物学
    培养单位: 附属瑞金医院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: 上海市瑞金医院血液学研究所
    邮编: 200025 邮箱地址: xsun@rockefeller.edu
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    洛克菲勒大学临床与转化医学中心(Rockefeller University Center for Clinical and Translational Science)会员
    中国病理生理学会实验血液学专业委员会委员
    洛克菲勒大学访问研究员(Visiting Investigator)
    国际学术杂志《Frontiers in Bioscience》特邀编辑(Managing Editor)
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    20152506白血病干细胞自我更新的转录和表观遗传调控机制的研究 上海市科学技术委员会高峰高原计划(第二轮) 2019-01~2021-01 100万元  课题负责人
    2018YFA0107802髓系白血病干细胞的分化及干预机制的单细胞组学研究国家重点研发计划重点专项课题 2018-07~2022-12 795万元  课题参与人
    81670094造血干细胞的蛋白翻译调控及其与低氧应激关联的研究国家自然科学基金面上项目 2017-01~2020-12 60万元  课题负责人
    20152506白血病干细胞自我更新的转录和表观遗传调控机制的研究上海市科学技术委员会高峰高原计划 2015-10~2018-09 100万元  课题负责人
    81470316AETFC转录因子复合物的翻译后修饰在急性髓系白血病中的作用机制的研究国家自然科学基金面上项目 2015-01~2018-12 75万元  课题负责人
    2013CB966801基于体细胞重编程和转分化技术获得病人特异的造血干细胞的研究国家重大科学研究计划课题 2013-01~2017-12 346万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Xie Y, Gao L, Xu C, Chu L, Gao L, Wu R, Liu Y, Liu T,, Ren R, Tang J, Zheng Y, Zhou Y, Shen S.  ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients  Haematologica  2020  105(4):925-936 
    Liu DJ, Zhang F, Chen Y, Jin Y, Zhang YL, Chen SB, Xie YY, Huang QH, Zhao WL, Wang L, Xu PF, Chen Z, Chen SJ, Li B, Zhang A,  setd2 knockout zebrafish is viable and fertile: differential and developmental-stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals  Cell Discovery  2020  in press 
    Chen BY, Song J, Hu CL, Chen SB, Zhang Q, Xu CH, Wu JC, Hou D, Sun M, Zhang YL, Liu N, Yu PC, Liu P, Zong LJ, Zhang JY, Dai RF, Lan F, Huang QH, Zhang SJ, Nimer SD, Chen Z, Chen SJ,, Wang L.  SETD2 Deficiency Accelerates MDS-associated Leukemogenesis via S100a9 in NHD13 Mice and Predicts Poor Prognosis in MDS  Blood  2020  135(25):2271-2285 
    , Chen SJ, Chen Z  Treating leukemia: differentiation therapy for mIDH2 AML  Cell Research  2019  29(6):427-428 
    Liu N, Song J, Xie Y, Wang XL, Rong B, Man N, Zhang MM, Zhang Q, Gao FF, Du MR, Zhang Y, Shen J, Xu CH, Hu CL, Wu JC, Liu P, Zhang YL, Xie YY, Liu P, Huang J, Huang QH, Lan F, Shen S, Nimer SD, Chen Z, Chen SJ, Roeder RG, Wang L,  Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis  Proceedings of the National Academy of Sciences of the United States of America  2019  116(3):890-899 
    Zhang MM, Liu N, Zhang YL, Rong B, Wang XL, Xu CH, Xie YY, Shen S, Zhu J, Nimer SD, Chen Z, Chen SJ, Roeder RG, Lan F, Wang L, Huang QH,  Destabilization of AETFC through C/EBPalpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation  Leukemia  2019  33(7):1822-1827 
    Xu Y, Man N, Karl D, Martinez C, Liu F, Sun J, Martinez CJ, Martin GM, Beckedorff F, Lai F, Yue J, Roisman A, Greenblatt S, Duffort S, Wang L,, Figueroa M, Shiekhattar R, Nimer S.  TAF1 plays a critical role in AML1-ETO driven leukemogenesis  Nature Communications  2019  10(1):4925 
    Zhang YL, Sun JW, Xie YY, Zhou Y, Liu P, Song JC, Xu CH, Wang L, Liu D, Xu AN, Chen Z, Chen SJ,, Huang QH  Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation  Cell Research  2018  28(4):476-490 
    , Chen Z, Chen SJ  Mutations in DNA Methyltransferases and Demethylases  The Encyclopedia of Cancer, 3rd Edition (edited by Boffetta P and Hainaut P, Academic Press)  2018  528-537 
    Kobayashi M, Chen S, Bai Y, Yao C, Gao R,, Mu C, Twiggs TA, Yu ZH, Boswell HS, Yoder MC, Kapur R, Mulloy JC, Zhang ZY, Liu Y  Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia  Leukemia  2017  31(6):1453-1457 
    Liu D, Huang QH,  Unbiased evidence for single E. coli colony containing diverse plasmids  PubRaw Science  2017  1(7):1-5 
    Man N, Tan Y,, Liu F, Cheng G, Greenblatt S, Martinez C, Karl DL, Ando K, Sun M, Hou D, Chen B, Xu M, Yang FC, Chen Z, Chen S, Nimer SD, Wang L  Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1 dependent manner  Blood  2017  129(20):2782-2792 
    Yang LS, Zhang XJ, Xie YY,, Zhao R, Huang QH  SUMOylated MAFB promotes colorectal cancer tumorigenesis  Oncotarget  2016  7(50):83488-83501 
    张凡, 黄秋花, 陈赛娟,  用斑马鱼模型研究低氧应激在造血和血液疾病中的作用  上海交通大学学报(医学版)  2016  36(8):1237-1241 
    Man N,, Tan Y, Cao MG, Liu F, Cheng G, Hatlen M, Xu H, Shah R, Chastain N, Liu N, Huang G, Zhou Y, Sheng M, Song J, Yang FC, Benezra R, Nimer SD, Wang L  Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin  Blood  2016  127(19):2322-2326 
    , Man N, Tan Y, Nimer S, Wang L  The role of histone acetyltransferases in normal and malignant hematopoiesis  Frontiers in Oncology  2015  5:108 
    Wang L, Man N,, Tan Y, Cao M, Liu F, Hatlen M, Xu H, Huang G, Mattlin M, Mehta A, Rampersaud E, Benezra R, Nimer S  Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression  Blood  2015  126(5):640-650 
    Zhang Y, Xie S, Zhou Y, Xie Y, Liu P, Sun M, Xiao H, Jin Y,, Chen Z, Huang Q, Chen S  H3K36 Histone Methyltransferase Setd2 Is Required for Murine Embryonic Stem Cell Differentiation toward Endoderm  Cell Reports  2014  8(6):1989-2002 
    , Wang Z, Wang L, Jiang Y, Kost N, Soong TD, Chen WY, Tang Z, Nakadai T, Elemento O, Fischle W, Melnick A, Patel DJ, Nimer SD, Roeder RG  A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis  Nature  2013  500(7460):93-97 
    Tang Z, Chen WY, Shimada M, Nguyen UT, Kim J,, Sengoku T, McGinty RK, Fernandez JP, Muir TW, Roeder RG  SET1 and p300 synergy, through coupled histone modifications, in transcriptional activation by p53  Cell  2013  154(2):297-310 
    Wang L, Gural A,, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, DeBlasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD  The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation  Science  2011  333(6043):765-769 
      编码多肽类激素基因的表达调控  临床内分泌学(陈家伦主编,上海科学技术出版社)  2011  第一篇第四章:25-35 
    Hu M,, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z  Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling  Proceedings of the National Academy of Sciences of the United States of America  2010  107(7):2956-2961 
    Xu PF, Zhu KY, Jin Y, Chen Y,, Deng M, Chen SJ, Chen Z, and Liu TX  Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity  Proceedings of the National Academy of Sciences of the United States of America  2010  107(6):2521-2526 
    Park JH,, Roeder RG  The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression  Molecular and Cellular Biology  2010  30(11):2750-2761 
    , Xu PF, Zhou T, Hu M, Fu CT, Zhang Y, Jin Y, Chen Y, Chen SJ, Huang QH, Liu TX, Chen Z  Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes  PloS One  2008  3:e1499 
    Wang L, Zhao WL, Yan JS, Liu P, Sun HP, Zhou GB, Weng ZY, Wu WL, Weng XQ,, Chen Z, Sun HD, Chen SJ  Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner  Cell Death and Differentiation  2007  14(2):306-317 
    , Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z  Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase  Journal of Biological Chemistry  2005  280(42):35261-35271 
    Song HD,, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y, Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT, Chen Z  Hematopoietic gene expression profile in zebrafish kidney marrow  Proceedings of the National Academy of Sciences of the United States of America  2004  101(46):16240-16245