• 基本信息
    导师姓名： 孙晓建 学科代码： 100100
    性别： 男 学科名称： 基础医学
    培养单位： 附属瑞金医院 三级学科
    导师类型： 博士生导师 专业领域名称：
    联系方式： 上海市瑞金医院血液学研究所 专业领域代码：
    邮编： 200025 邮箱地址： xsun@rockefeller.edu
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    洛克菲勒大学临床与转化医学中心（Rockefeller University Center for Clinical and Translational Science）会员
    中国病理生理学会实验血液学专业委员会委员
    洛克菲勒大学访问研究员（Visiting Investigator）
    国际学术杂志《Frontiers in Bioscience》特邀编辑（Managing Editor）
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    20152506白血病干细胞自我更新的转录和表观遗传调控机制的研究 上海市科学技术委员会高峰高原计划（第二轮） 2019-01~2021-01 100万元  课题负责人
    2018YFA0107802髓系白血病干细胞的分化及干预机制的单细胞组学研究国家重点研发计划重点专项课题 2018-07~2022-12 795万元  课题参与人
    81670094造血干细胞的蛋白翻译调控及其与低氧应激关联的研究国家自然科学基金面上项目 2017-01~2020-12 60万元  课题负责人
    20152506白血病干细胞自我更新的转录和表观遗传调控机制的研究上海市科学技术委员会高峰高原计划 2015-10~2018-09 100万元  课题负责人
    81470316AETFC转录因子复合物的翻译后修饰在急性髓系白血病中的作用机制的研究国家自然科学基金面上项目 2015-01~2018-12 75万元  课题负责人
    2013CB966801基于体细胞重编程和转分化技术获得病人特异的造血干细胞的研究国家重大科学研究计划课题 2013-01~2017-12 346万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Li JF, Cheng WY, Lin XJ, Wen LJ, Wang K, Zhu YM, Zhu HM, Chen XJ, Zhang YL, Yin W, Zhang JN, Yi X, Zhang F, Weng XQ, Wang SY, Jiang L, Wu HY, Ren JQ, Lin XJ, Qiao N, Dai YT, Fang H, Tan Y,, Lv G, Yan XY, Chen SN, Chen Z, Jin J, Wu DP, Ren RB, Chen SJ, Shen Y  Aging and comprehensive molecular profiling in acute myeloid leukemia  Proceedings of the National Academy of Sciences of the United States of America  2024  121(10):e2319366121 
    Feng CZ, Li NZ, Hu XB, Xie YY, Huang QH, Zhang J, Chen Z, Chen SJ, Wang F,  The LIFR-targeting small molecules EC330/EC359 are potent ferroptosis inducers  Genes & Diseases  2023  10(3):735-738 
    Liu MK, Liu F, Dai YT, Weng XQ, Cheng LL, Fan LQ, Liu H, Jiang L,, Fang H, Wang L, Zhao WL  Case Report: Molecular and microenvironment change upon midostaurin treatment in mast cell leukemia at single-cell level  Frontiers in Immunology  2023  14:1210909 
    Liu D, Xu C, Liu Y, Ouyang W, Lin S, Xu A, Zhang Y, Xie Y, Huang Q, Zhao W, Chen Z, Wang L, Chen S, Huang J, Wu ZB,  A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors  Frontiers of Medicine  2023  17(3):458-475 
    Hou S, Wang X, Guo T, Lan Y, Yuan S, Yang S, Zhao F, Fang A, Liu N, Yang W, Chu Y, Jiang E, Cheng T,, Yuan W  PHF6 maintains acute myeloid leukemia via regulating NF-κB signaling pathway  Leukemia  2023  37(8):1626-1637 
    Fei MY, Wang Y, Chang BH, Xue K, Dong F, Huang D, Li XY, Li ZJ, Hu CL, Liu P, Wu JC, Yu PC, Hong MH, Chen SB, Xu CH, Chen BY, Jiang YL, Liu N, Zhao C, Jin JC, Hou D, Chen XC, Ren YY, Deng CH, Zhang JY, Zong LJ, Wang RJ, Gao FF, Liu H, Zhang QL, Wu LY, Yan J, Shen S, Chang CK,, Wang L  The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment  Blood  2023  142(10):903-917 
    Li XY, Wu JC, Liu P, Li ZJ, Wang Y, Chen BY, Hu CL, Fei MY, Yu PC, Jiang YL, Xu CH, Chang BH, Chen XC, Zong LJ, Zhang JY, Fang Y,, Xue K, Wang L, Chen SB, Jiang SY, Gui AL, Yang L, Gu JJ, Yu BH, Zhang QL, Wang L  Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma. Leukemia  Leukemia  2023  37(1):164-177 
    Zeng QY, Zhang F, Zhang JH, Hei Z, Li ZH, Huang MH, Fang P, Wang ED,, Zhou XL  Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development  Journal of Biological Chemistry  2023  299(5):104704 
      激素及基因表达的分子机制  临床内分泌学 第2版（陈家伦、宁光 主编，上海科学技术出版社）  2022  第一篇第四章:23-36 
    Dai YT, Zhang F, Fang H, Li JF, Lu G, Jiang L, Chen B, Mao DD, Liu YF, Wang J, Peng LJ, Feng C, Chen HF, Mu JX, Zhang QL, Wang H, Ariffin H, Moy TA, Wang JH, Lou YJ, Chen SN, Wang Q, Liu H, Shan Z, Matsumura I, Miyazaki Y, Yasuda T, Dou LP, Yan XJ, Yan JS, Yeoh AE, Wu DP, Kiyoi H, Hayakawa F, Jin J, Wang SY,, Mi JQ, Chen Z, Huang JY, Chen SJ  Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases  Proceedings of the National Academy of Sciences of the United States of America  2022  119(15):e2120787119 
    Chen Q, Cevher MA, Jiang Q, Wang S,, Roeder RG, Chen M  LYL1 facilitates AETFC assembly and gene activation by recruiting CARM1 in t(8;21) AML  Proceedings of the National Academy of Sciences of the United States of America  2022  119(42):e2213718119 
    Fang Y, Zhang MC, Xu PP, Zhang SJ, Wang L, Cheng S, Fu D, Chang CK,, Zhao Y, Tang YJ, Tian X, Yi HM, Liu F, Zhao WL  Integrative genome-wide chromatin accessibility and transcriptome profiling of diffuse large B-cell lymphoma  Clinical and Translational Medicine  2022  12(7):e975 
    Zhang YF, Wang XL, Xu CH, Liu N, Zhang L, Zhang YM, Xie YY, Zhang YL, Huang QH, Wang L, Chen Z, Chen SJ, Roeder RG, Shen S, Xue K,  A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation  Frontiers in Cell and Developmental Biology  2022  10:992714 
    Hu CL, Chen BY, Li Z, Yang T, Xu CH, Yang R, Yu PC, Zhao J, Liu T, Liu N, Shan B, Zhang Q, Song J, Fei MY, Zong LJ, Zhang JY, Wu JC, Chen SB, Wang Y, Chang B, Hou D, Liu P, Jiang Y, Li X, Chen X, Deng CH, Ren YY, Wang R, Jin J, Xue K, Zhang Y, Du M, Shi J, Wu LY, Chang CK, Shen S, Chen Z, Chen SJ, Liu X,, Zheng M, Wang L  Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia  Cell Research  2022  32(12):1105-1123 
    Hao C, Shao X, Song J, Peng M, Lao Y, Mack R, Zhang L, Wei W, Liu N, Wang T, Wu Y, Feng L, Yin L, Wang S,, Zhang J, Li B  SIRT2 regulates proliferation and chemotherapy response of MLL-ENL-driven acute myeloid leukemia  Biochemical and Biophysical Research Communications  2022  596:36-42 
    Wang N, Qin W, Zheng Z, Zhao M, Xiong J, Fang H, Sun R, Wang Y, Li C, Dong L,, Wang L, Xu P, Cheng S, Xu H, Zhang F, Zhao W  Hepatitis B virus-associated follicular lymphoma presents T-cell inflamed phenotype and response to lenalidomide  Cancer Communications  2022  42(2):170-174 
    Cheng WY, Li JF, Zhu YM, Lin XJ, Wen LJ, Zhang F, Zhang YL, Zhao M, Fang H, Wang SY, Lin XJ, Qiao N, Yin W, Zhang JN, Dai YT, Jiang L,, Xu Y, Zhang TT, Chen SN, Zhu HH, Chen Z, Jin J, Wu DP, Shen Y, Chen SJ  Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia  Proceedings of the National Academy of Sciences of the United States of America  2022  119(49):e2211429119 
    Zhang F, Zeng QY, Xu H, Xu AN, Liu DJ, Li NZ, Chen Y, Jin Y, Xu CH, Feng CZ, Zhang YL, Liu D, Liu N, Xie YY, Yu SH, Yuan H, Xue K, Shi JY, Liu TX, Xu PF, Zhao WL, Zhou Y, Wang L, Huang QH, Chen Z, Chen SJ, Zhou XL,  Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis  Cell Discovery  2021  7(1):98 
    Xu S, Wang S, Xing S, Yu D, Rong B, Gao H, Sheng M, Tan Y, Zhang Y,, Wang K, Xue K, Shi Z, Lan F  KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2  Blood Advances  2021  5(17):3241-3253 
    Dai Y, Xu A, Li J, Wu L, Yu S, Chen J, Zhao W,, Huang J  CytoTree: an R/Bioconductor package for analysis and visualization of flow and mass cytometry data  BMC Bioinformatics  2021  22(1):138 
    Huang YH, Cai K, Xu PP, Wang L, Huang CX, Fang Y, Cheng S,, Liu F, Huang JY, Ji MM, Zhao WL  CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis  Signal Transduction and Targeted Therapy  2021  6(1):10 
    Liu MK,, Gao XD, Qian Y, Wang L, Zhao WL  Methylation alterations and advance of treatment in lymphoma  Frontiers in Bioscience-Landmark  2021  26(9):602-613 
    Chen Z, Xie Y, Liu D, Liu P, Li F, Zhang Z, Zhang M, Wang X, Zhang Y,, Huang Q  Downregulation of miR-142a Contributes to the Enhanced Anti-Apoptotic Ability of Murine Chronic Myelogenous Leukemia Cells  Frontiers in Oncology  2021  11:718731 
    Huang Y, Yu SH, Zhen WX, Cheng T, Wang D, Lin JB, Wu YH, Wang YF, Chen Y, Shu LP, Wang Y,, Zhou Y, Yang F, Hsu CH, Xu PF  Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2  Theranostics  2021  11(14):6891-6904 
    Xiong J, Wang N, Zhong HJ, Cui BW, Cheng S, Sun R, Chen JY, Xu PP, Cai G, Wang L,, Huang JY, Zhao WL  SLC1A1 mediated glutamine addiction and contributed to natural killer T-cell lymphoma progression with immunotherapeutic potential  EBioMedicine  2021  72:103614 
    Fu YK, Tan Y, Wu B, Dai YT, Xu XG, Pan MM, Chen ZW, Qiao N, Wu J, Jiang L, Lu J, Chen B, Rein A, Izraeli S,, Huang JY, Huang QH, Chen Z, Chen SJ  Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model   Cell Death & Disease  2021  12(6):568 
    Song J, Du L, Liu P, Wang F, Zhang B, Xie Y, Lu J, Jin Y, Zhou Y, Lv G, Zhang J, Chen S, Chen Z,, Zhang Y, Huang Q  Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2-/- acute myeloid leukemia  Cancer Communications  2021  41(9):867-888 
    Xue K, Wu J, Li XY, Li R, Zhang Q, Chang JJ, Liu Y, Xu C, Zhang JY,, Gu JJ, Guo W, Wang L  Chidamide triggers BTG1-mediated autophagy and reverses the chemotherapy resistance in the relapsed/refractory B cell lymphoma  Cell Death & Disease  2021  12(10):900 
    刘梦珂, 纪濛濛, 程林, 黄金艳,, 赵维莅, 王黎  黄芩苷抗肿瘤作用机制的研究进展  上海交通大学学报 （医学版）  2021  41(2):246-250 
    Xie Y, Gao L, Xu C, Chu L, Gao L, Wu R, Liu Y, Liu T,, Ren R, Tang J, Zheng Y, Zhou Y, Shen S.  ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients  Haematologica  2020  105(4):925-936 
    Liu DJ, Zhang F, Chen Y, Jin Y, Zhang YL, Chen SB, Xie YY, Huang QH, Zhao WL, Wang L, Xu PF, Chen Z, Chen SJ, Li B, Zhang A,  setd2 knockout zebrafish is viable and fertile: differential and developmental-stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals  Cell Discovery  2020  6:72 
    Chen BY, Song J, Hu CL, Chen SB, Zhang Q, Xu CH, Wu JC, Hou D, Sun M, Zhang YL, Liu N, Yu PC, Liu P, Zong LJ, Zhang JY, Dai RF, Lan F, Huang QH, Zhang SJ, Nimer SD, Chen Z, Chen SJ,, Wang L.  SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS  Blood  2020  135(25):2271-2285 
    , Chen SJ, Chen Z  Treating leukemia: differentiation therapy for mIDH2 AML  Cell Research  2019  29(6):427-428 
    Liu N, Song J, Xie Y, Wang XL, Rong B, Man N, Zhang MM, Zhang Q, Gao FF, Du MR, Zhang Y, Shen J, Xu CH, Hu CL, Wu JC, Liu P, Zhang YL, Xie YY, Liu P, Huang J, Huang QH, Lan F, Shen S, Nimer SD, Chen Z, Chen SJ, Roeder RG, Wang L,  Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis  Proceedings of the National Academy of Sciences of the United States of America  2019  116(3):890-899 
    Zhang MM, Liu N, Zhang YL, Rong B, Wang XL, Xu CH, Xie YY, Shen S, Zhu J, Nimer SD, Chen Z, Chen SJ, Roeder RG, Lan F, Wang L, Huang QH,  Destabilization of AETFC through C/EBPalpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation  Leukemia  2019  33(7):1822-1827 
    Xu Y, Man N, Karl D, Martinez C, Liu F, Sun J, Martinez CJ, Martin GM, Beckedorff F, Lai F, Yue J, Roisman A, Greenblatt S, Duffort S, Wang L,, Figueroa M, Shiekhattar R, Nimer S.  TAF1 plays a critical role in AML1-ETO driven leukemogenesis  Nature Communications  2019  10(1):4925 
    Zhang YL, Sun JW, Xie YY, Zhou Y, Liu P, Song JC, Xu CH, Wang L, Liu D, Xu AN, Chen Z, Chen SJ,, Huang QH  Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation  Cell Research  2018  28(4):476-490 
    , Chen Z, Chen SJ  Mutations in DNA methyltransferases and demethylases  The Encyclopedia of Cancer, 3rd Edition (edited by Boffetta P and Hainaut P, Academic Press)  2018  528-537 
    Kobayashi M, Chen S, Bai Y, Yao C, Gao R,, Mu C, Twiggs TA, Yu ZH, Boswell HS, Yoder MC, Kapur R, Mulloy JC, Zhang ZY, Liu Y  Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia  Leukemia  2017  31(6):1453-1457 
    Liu D, Huang QH,  Unbiased evidence for single E. coli colony containing diverse plasmids  PubRaw Science  2017  1(7):1-5 
    Man N, Tan Y,, Liu F, Cheng G, Greenblatt S, Martinez C, Karl DL, Ando K, Sun M, Hou D, Chen B, Xu M, Yang FC, Chen Z, Chen S, Nimer SD, Wang L  Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1 dependent manner  Blood  2017  129(20):2782-2792 
    Yang LS, Zhang XJ, Xie YY,, Zhao R, Huang QH  SUMOylated MAFB promotes colorectal cancer tumorigenesis  Oncotarget  2016  7(50):83488-83501 
    张凡, 黄秋花, 陈赛娟,  用斑马鱼模型研究低氧应激在造血和血液疾病中的作用  上海交通大学学报（医学版）  2016  36(8):1237-1241 
    Man N,, Tan Y, Cao MG, Liu F, Cheng G, Hatlen M, Xu H, Shah R, Chastain N, Liu N, Huang G, Zhou Y, Sheng M, Song J, Yang FC, Benezra R, Nimer SD, Wang L  Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin  Blood  2016  127(19):2322-2326 
    , Man N, Tan Y, Nimer S, Wang L  The role of histone acetyltransferases in normal and malignant hematopoiesis  Frontiers in Oncology  2015  5:108 
    Wang L, Man N,, Tan Y, Cao M, Liu F, Hatlen M, Xu H, Huang G, Mattlin M, Mehta A, Rampersaud E, Benezra R, Nimer S  Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression  Blood  2015  126(5):640-650 
    Zhang Y, Xie S, Zhou Y, Xie Y, Liu P, Sun M, Xiao H, Jin Y,, Chen Z, Huang Q, Chen S  H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm  Cell Reports  2014  8(6):1989-2002 
    , Wang Z, Wang L, Jiang Y, Kost N, Soong TD, Chen WY, Tang Z, Nakadai T, Elemento O, Fischle W, Melnick A, Patel DJ, Nimer SD, Roeder RG  A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis  Nature  2013  500(7460):93-97 
    Tang Z, Chen WY, Shimada M, Nguyen UT, Kim J,, Sengoku T, McGinty RK, Fernandez JP, Muir TW, Roeder RG  SET1 and p300 synergy, through coupled histone modifications, in transcriptional activation by p53  Cell  2013  154(2):297-310 
    Wang L, Gural A,, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, DeBlasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD  The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation  Science  2011  333(6043):765-769 
      编码多肽类激素基因的表达调控  临床内分泌学（陈家伦 主编，上海科学技术出版社）  2011  第一篇第四章:25-35 
    Hu M,, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z  Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling  Proceedings of the National Academy of Sciences of the United States of America  2010  107(7):2956-2961 
    Xu PF, Zhu KY, Jin Y, Chen Y,, Deng M, Chen SJ, Chen Z, and Liu TX  Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity  Proceedings of the National Academy of Sciences of the United States of America  2010  107(6):2521-2526 
    Park JH,, Roeder RG  The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression  Molecular and Cellular Biology  2010  30(11):2750-2761 
    , Xu PF, Zhou T, Hu M, Fu CT, Zhang Y, Jin Y, Chen Y, Chen SJ, Huang QH, Liu TX, Chen Z  Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes  PLoS One  2008  3:e1499 
    Wang L, Zhao WL, Yan JS, Liu P, Sun HP, Zhou GB, Weng ZY, Wu WL, Weng XQ,, Chen Z, Sun HD, Chen SJ  Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner  Cell Death and Differentiation  2007  14(2):306-317 
    , Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z  Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase  Journal of Biological Chemistry  2005  280(42):35261-35271 
    Song HD,, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y, Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT, Chen Z  Hematopoietic gene expression profile in zebrafish kidney marrow  Proceedings of the National Academy of Sciences of the United States of America  2004  101(46):16240-16245