- 基本信息
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导师姓名：
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徐敏
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学科代码：
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100201
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性别：
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女
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学科名称：
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内科学
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培养单位：
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附属瑞金医院
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三级学科
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内分泌与代谢病
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海市徐家汇路573号
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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della.xumin@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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Editorial Board Member, Food & Nutrition: Current Research.
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上海市医学会糖尿病学专科分会代谢病学组委员
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中华糖尿病学会胰岛Beta细胞学组委员
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- 科研项目
| 82270859 | DOCK6基因及变异对糖脂代谢的作用及机制研究 | 国家自然科学基金委 |
2023-01~2026-12
|
52万元
| 课题负责人 |
| 81941017 | 基于队列和饮食-运动干预的肠道菌群相关代谢物与老年人 心血管健康的关联和机制研究 | 国家自然基金委员会 |
2020-01~2022-12
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90万元
| 课题负责人 |
| 20152508 Round 2 | 高峰高原学科计划-临床专职科研 | 上海市教委 |
2019-01~2022-01
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100万元
| 课题负责人 |
| 2018YFC1311705 | 糖尿病临床研究数据采集标准、交换机制及应用研究 | 国家重点研发计划“重大慢性非传染性疾病防控研究”专项“重大慢病流行病学监测大数据平台构建和关键技术研究”项目 |
2018-07~2020-12
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250万元
| 课题负责人 |
| 81770842 | 视黄醇结合蛋白-4在白色脂肪棕色化及体重调节中的作用及机制研究 | 国家自然科学基金面上项目 |
2018-01~2021-12
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54万元
| 课题负责人 |
| 00-000 | 基于新型生物大数据的糖尿病防治路径及推广应用 | 上海市科委 |
2017-07~2020-06
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150万元
| 课题负责人 |
| SHDC12016202 | 2型糖尿病预警模型开发及推广应用 | 上海申康医院发展中心 |
2016-11~2019-11
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15万元
| 课题负责人 |
| 000-00 | SMC-晨星优秀青年教师（A类计划） | 上海交通大学 |
2016-09~2019-08
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30万元
| 课题负责人 |
| 2016YFC1304904 | 环境、行为及生物危险因素对 2 型糖尿病发生发展影响的研究 | 国家重点研发计划课题 |
2016-07~2020-12
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117万元
| 课题参与人 |
| 2015BAI12B14 | 中国成人糖尿病的发病危险因素、动态监测及综合防治 | 国家科技支撑计划 |
2015-04~2017-12
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939万元
| 课题参与人 |
| 81471062 | 谷氨酰胺酰基环化酶同工酶（QPCTL）在脂肪发育及体重调节中的作用及机制研究 | 国家自然基金委，面上项目 |
2015-01~2018-12
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73万元
| 课题负责人 |
| 20152508 | 临床专职科研 | 上海交通大学医学院“高原高峰计划” |
2015-01~2017-12
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100万元
| 课题负责人 |
| 14PJD024 | 肥胖及糖代谢相关遗传变异位点与环境因素交互作用的研究 | 上海市浦江人才计划项目 |
2014-09~2016-08
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20万元
| 课题负责人 |
| 81270877 | 锌转运蛋白8基因（SLC30A8）pre-mRNA选择性剪接的影响机制 | 国家自然基金委，面上项目 |
2013-01~2016-12
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65万元
| 课题负责人 |
| 2011-293 | 新的脂肪因子SFRP5在胰岛素抵抗及相关代谢异常中的作用研究 | 上海市卫生局局级课题 |
2012-01~2014-12
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3万元
| 课题负责人 |
| 2012AA02A509 | 2型糖尿病冠心病早期诊治的分子分型标记物研究 | 国家高技术研究发展计划（863计划） |
2012-01~2015-12
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189万元
| 课题参与人 |
| 000-00 | 新的脂肪因子SFRP5在胰岛素抵抗及相关代谢异常中的作用研究 | 院级课题，优秀青年教师 |
2011-08~2013-07
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2万元
| 课题负责人 |
| 30800536 | 锌转运蛋白－8基因(SLC30A8)影响胰岛β细胞功能研究 | 国家自然基金委，青年项目 |
2009-01~2011-12
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21万元
| 课题负责人 |
| 08ZR1417000 | 锌转运蛋白－8基因(SLC30A8)影响胰岛β细胞功能研究 | 上海市科委，自然科学基金 |
2008-08~2010-09
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10万元
| 课题负责人 |
- 学术论文
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He R, Zheng R, Zheng J, Li M, Wang T, Zhao Z, Wang S, Lin H, Lu J, Chen Y, Xu Y, Wang W,, Bi Y, Ning G.
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Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study
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J Clin Endocrinol Metab
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2023
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108(6):1432-1441.
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Dai H, Hou T, Wang Q, Hou Y, Wang T, Zheng J, Lin H, Zhao Z, Li M, Wang S, Zhang D, Dai M, Zheng R, Lu J, Xu Y, Chen Y, Ning G, Wang W, Bi Y,
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Causal relationships between the gut microbiome, blood lipids, and heart failure: a Mendelian randomization analysis.
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Eur J Prev Cardiol.
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2023
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30(12):1274-1282. doi:10.1093/eurjpc/zwad171
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Dai H, Zheng L, Zhu Z, Geng X, Hou T, Wang Q, Zhu Y, Lin H, Wang S, Zheng R, Zhao Z, Li M, Lu J, Xu Y, Wang T, Liu J, Ning G, Wang W, Bi Y, Zheng J,
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Evaluation of the Effect of Sodium-Glucose Cotransporter 2 Inhibition on Fracture Risk: Evidence From Mendelian Randomization and Genetic Association Study.
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J Bone Miner Res.
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2023
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doi:10.1002/jbmr.4880
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Hou Y, Dai H, Chen N, Zhao Z, Wang Q, Hou T, Zheng J, Wang T, Li M, Lin H, Wang S, Zheng R, Lu J, Xu Y, Chen Y, Liu R, Ning G, Wang W, Bi Y, Wang J,
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Whole blood-based transcriptional risk score for nonobese type 2 diabetes predicts dynamic changes in glucose metabolism
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J Clin Endocrinol Metab
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2023
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doi:10.1210/clinem/dgad466
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Hou T, Dai H, Wang Q, Hou Y, Zhang X, Lin H, Wang S, Li M, Zhao Z, Lu J, Xu Y, Chen Y, Gu Y, Zheng J, Wang T, Wang W, Bi Y, Ning G,
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Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization.
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Front Immunol.
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2023
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Published 2023 Mar 30. doi:10.3389/fimmu.2023.1148591
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Zhao Z, Cao Q, Lu J, Lin H, Gao Z,, Xu Y, Wang T, Li M, et al.
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Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults.
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JAMA Netw Open.
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2023
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6(6):e2319038.
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, Zhao Z, Shen F, et al.
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Modification effect of changes in cardiometabolic traits in association between kidney stones and cardiovascular events.
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Front Cardiovasc Med.
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2022
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Published 2022 Jul 26. doi:10.3389/fcvm.2022.923981
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Hou T, Li M, Lin H, Zhao Z, Lu J, Wang T, Xu Y, Wang W, Bi Y, Ning G,
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The Causal Effect of Systolic Blood Pressure Lowering on Vascular Outcomes in Diabetes: A Mendelian Randomization Study.
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J Clin Endocrinol Metab.
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2022
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107(9):2616-2625.
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Ye C, Kong L, Zhao Z, Li M, Wang S, Lin H, Xu Y, Lu J, Chen Y, Xu Y, Wang W, Ning G, Bi Y,, Wang T.
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Causal Associations of Obesity With Chronic Kidney Disease and Arterial Stiffness: A Mendelian Randomization Study.
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J Clin Endocrinol Metab
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2022
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107(2):e825-e835.
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Hou Y, Xiang J, Dai H, Wang T, Li M, Lin H, Wang S, Xu Y, Lu J, Chen Y, Wang W, Ning G, Zhao Z, Bi Y,
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New clusters of serum electrolytes aid in stratification of diabetes and metabolic risk.
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J Diabetes.
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2022
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14(2):121-133.
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Zheng J,, Walker V, et al.
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Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study.
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Diabetologia.
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2022
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65(10):1664-1675.
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Xiang J, Dai H, Hou Y, Wang Q, Wang T, Li M, Zhao Z, Lu J, Dai M, Zhang D, Xu Y, Ning G, Wang W, Wang J, Bi Y,
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Sexual Dimorphism in the Association of Serum Retinol-Binding Protein-4 With Long-Term Dynamic Metabolic Profiles in Non-Diabetes.
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Front Endocrinol (Lausanne).
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2022
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13:880467.
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, Qi Y, Chen G, et al.
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The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study.
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Front Endocrinol (Lausanne).
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2022
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13:927067.
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Guo J, Huang X, Zhang C, Huang P, Li Y, Wen F, Wang X, Yang N,, Bi Y, Ning G, Li L, Wang W, Cao Y.
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The blood virome of 10,585 individuals from the ChinaMAP.
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Cell Discov.
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2022
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8(1):113.
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Lin H, Xuan L, Xiang J, Hou Y, Dai H, Wang T, Zhao Z, Wang S, Lu J, Xu Y, Chen Y, Wang W, Ning G, Bi Y, Li M,
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Changes in adiposity modulate the APOA5 genetic effect on blood lipids: A longitudinal cohort study
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Atherosclerosis.
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2022
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350:1-8.
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, Zheng J, Hou T, et al.
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SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study.
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Diabetes Care.
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2022
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45(11):2718-2728.
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Jia X, Xuan L, Dai H, Zhu W, Deng C, Wang T, Li M, Zhao Z, Xu Y, Lu J, Bi Y, Wang W, Chen Y,, Ning G.
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Fruit intake, genetic risk and type 2 diabetes: a population-based gene-diet interaction analysis.
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Eur J Nutr.
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2021
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60(5):2769-2779.
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Zhu Y, Zheng R, Hu C, Qin G, Wang B, Wang T, Yu X, Tang X, Hu R, Su Q, Zhang J, Zhang Y, Zhao Z, Xu Y, Li M, Chen Y, Wang S, Shi L, Wan Q, Chen G, Dai M, Zhang D, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Ye Z, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Chen L, Zhao J, Mu Y, Yan L, Wang W, Ning G, Bi Y, Lu J,
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Association of early adulthood weight and subsequent weight change with cardiovascular diseases: Findings from REACTION study
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Int J Cardiol .
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2021
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332:209-215.
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Wang T, Zhao Z, Yu X, Zeng T,, Xu Y, Hu R, Chen G, Su Q, Mu Y, Chen L, Tang X, Yan L, Qin G, Wan Q, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Ye Z, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Zhao J, Xu Y, Li M, Chen Y, Wang S, Ning G, Bi Y, Shi L, Lu J, Wang W.
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Age-specific modifiable risk factor profiles for cardiovascular disease and all-cause mortality: a nationwide, population-based, prospective cohort study.
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Lancet Reg Health West Pac.
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2021
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17:100277.
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Zuo G, Xuan L, Xin Z, Xu Y, Lu J, Chen Y, Dai M, Zhang D, Wang W, Li M, Bi Y, Ning G,
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New Nonalcoholic Fatty Liver Disease and Fibrosis Progression Associate With the Risk of Incident Chronic Kidney Disease.
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J Clin Endocrinol Metab
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2021
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106(10):e3957-e3968.
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Dai H, Xiang J, Hou Y, Xuan L, Wang T, Li M, Zhao Z, Xu Y, Lu J, Chen Y, Wang W, Ning G, Bi Y,
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Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals.
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Nutr Metab (Lond).
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2021
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18(1):21.
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Li L, Huang P, Sun X, Wang S,, Liu S, Feng Z, Zhang Q, Wang X, Zheng X, Dai M, Bi Y, Ning G, Cao Y, Wang W.
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The ChinaMAP reference panel for the accurate genotype imputation in Chinese populations.
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Cell Res.
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2021
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31(12):1308-1310.
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Deng C, Niu J, Xuan L, Zhu W, Dai H, Zhao Z, Li M, Lu J, Xu Y, Chen Y, Wang W, Ning G, Bi Y,, Wang T. 2020 Feb 10;
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Association of QTc Interval with Risk of Cardiovascular Diseases and Related Vascular Traits: A Prospective and Longitudinal Analysis.
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Glob Heart.
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2020
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15(1):13.
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Li M, Xu Y, Wan Q, Shen F,, Zhao Z, Lu J, Gao Z, Chen G, Wang T, Xu Y, Zhao J, Chen L, Shi L, Hu R, Ye Z, Tang X, Su Q, Qin G, Wang G, Luo Z, Qin Y, Huo Y, Li Q, Zhang Y, Chen Y, Liu C, Mu Y, Wang Y, Wu S, Yang T, Chen L, Yu X, Yan L, Deng H, Ning G, Bi Y, Wang W.
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Individual and Combined Associations of Modifiable Lifestyle and Metabolic Health Status With New-Onset Diabetes and Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study.
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Diabetes Care.
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2020
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43(8):1929-1936.
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Cao Y, Li L,, Feng Z, Sun X, Lu J, Xu Y, Du P, Wang T, Hu R, Ye Z, Shi L, Tang X, Yan L, Gao Z, Chen G, Zhang Y, Chen L, Ning G, Bi Y, Wang W; ChinaMAP Consortium.
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The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals.
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Cell Res.
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2020
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10.1038/s41422-020-0322-9.
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Wang T, Lu J, Shi L, Chen G,, Xu Y, Su Q, Mu Y, Chen L, Hu R, Tang X, Yu X, Li M, Zhao Z, Chen Y, Yan L, Qin G, Wan Q, Dai M, Zhang D, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Ye Z, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Zhao J, Lai S, Bi Y, DeFronzo RA, Wang W, Ning G; China Cardiometabolic Disease and Cancer Cohort Study Group.
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Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study.
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Lancet Diabetes Endocrinol.
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2020
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8(2):115-124.
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Xuan L, Wang T, Dai H, Wang B, Xiang J, Wang S, Lin H, Li M, Zhao Z, Lu J, Chen Y, Xu Y, Wang W,, Bi Y, Ning G.
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Serum lipoprotein (a) associates with a higher risk of reduced renal function: a prospective investigation
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J Lipid Res
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2020
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0(0):00-00
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Zhu W, Wang S, Dai H, Xuan L, Deng C, Wang T, Zhao Z, Li M, Lu J, Xu Y, Chen Y, Wang W, Bi Y,, Ning G.
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Serum total bile acids associate with risk of incident type 2 diabetes and longitudinal changes in glucose-related metabolic traits.
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J Diabetes.
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2020
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12(8):616-625.
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Zhang Y, Peng K, Liu J, Chen X, Wang T, Li M, Chen Y, Xu Y, Lu J, Bi Y, Wang W, Ning G,
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Carotid intima-media thickness and plagues are associated with indicators of peripheral artery diseases in patients with diabetes.
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Diabetes Res Clin Pract
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2018
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144(10):245-251
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Xuan L, Hou Y, Wang T, Li M, Zhao Z, Lu J, Xu Y, Chen Y, Qi L, Wang W, Bi Y,
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Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese.
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Acta Diabetol
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2018
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55(9):901-908
|
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Wang T,, Bi Y, Ning G.
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Interplay between diet and genetic susceptibility in obesity and related traits.
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Front Med
|
2018
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12(6):601-607
|
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Xuan L, Zhao Z, Jia X, Hou Y, Wang T, Li M, Lu J, Xu Y, Chen Y, Qi L, Wang W, Bi Y,
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Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis.
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Front Med
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2018
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12(6):678-687
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Ding L, Xu Y, Wang L,, et al.
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The cardiometabolic risk profile of Chinese adults with diabetes: A nationwide cross-sectional survey.
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J Diabetes Complications.
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2017
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31(1):43-52
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Hao M, Ding L, Xuan L, Wang T, Li M, Zhao Z, Lu J, Xu Y, Chen Y, Wang W, Bi Y,, Ning G
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Urinary bisphenol A concentration and the risk of central obesity in Chinese adults: A prospective study.
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J Diabetes.
|
2017
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xx(xx):xx-xx
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Bi Y, Wang W,, et al.
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Diabetes Genetic Risk Score Modifies Effect of Bisphenol A Exposure on Deterioration in Glucose Metabolism.
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J Clin Endocrinol Metab.
|
2016
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101(1):143-50.
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, Bi Y, Huang Y, Xie L, Hao M, Zhao Z, Xu Y, Lu J, Chen Y, Sun Y, Qi L, Wang W, Ning G.
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Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.
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EBioMedicine.
|
2016
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6:162-70.
|
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, Huang Y, Xie L, Peng K, Ding L, Lin L, Wang P, Hao M, Chen Y, Sun Y, Qi L, Wang W, Ning G, Bi Y.
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Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis.
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Diabetes.
|
2016
|
65(6):1731-40
|
|
Wang T, Xu Y,, Ning G, Lu J, Dai M, Xu B, Sun J, Sun W, Lai S, Bi Y, Wang W.
|
Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study.
|
Am J Epidemiol.
|
2016
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184(4):295-301.
|
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Huang Y,, Xie L, Wang T, Huang X, Lv X, Chen Y, Ding L, Lin L, Wang W, Bi Y, Sun Y, Zhang Y, Ning G.
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Obesity and peripheral arterial disease: A Mendelian Randomization analysis.
|
Atherosclerosis.
|
2016
|
247:218-24
|
|
Bi Y, Wang L, Xu Y, Jiang Y, He J, Zhang M, Zhou M, Li Y,, Lu J, Wang T, Ding L, Dai M, Zhang D, Chen CS, Lai S, Wang W, Wang L, Ning G; 2012 China Noncommunicable Disease and Risk Factor Surveillance in Migrant Workers Study Group.
|
Diabetes-related metabolic risk factors in internal migrant workers in China: a national surveillance study.
|
Lancet Diabetes Endocrinol.
|
2016
|
4(2):125-35.
|
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Huang X, Ding L, Peng K, Lin L, Wang T, Zhao Z, Xu Y, Lu J, Chen Y, Wang W, Bi Y, Ning G,
|
Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation.
|
J Transl Med.
|
2016
|
14(1):336-336
|
|
, Lv X, Xie L, et al.
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Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis.
|
Diabetologia.
|
2016
|
59(2):307-15.
|
|
Huang X,, Chen Y, et al.
|
Validation of the Fatty Liver Index for Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Chinese.
|
Medicine (Baltimore).
|
2015
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94(40):e1682.
|
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Zhou Y, Zhao L, Wang T, Hong J, Zhang J, Xu B, Huang X,, Bi Y.
|
Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population.
|
J Atheroscler Thromb. 2015 Oct 1. [Epub ahead of print]
|
2015
|
00-00
|
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Wang T, Xu Y,, et al.
|
Awareness, treatment and control of cardiometabolic disorders in Chinese adults with diabetes: a national representative population study.
|
Cardiovasc Diabetol.
|
2015
|
14:28.
|
|
He M,, Zhang B,et al.
|
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
|
Hum Mol Genet.
|
2015
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24(6):1791-800.
|
|
, Zhou Y, Xu B,et al.
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The associations of smoking and alcohol consumption with impaired β cell function in Chinese men.
|
J Diabetes.
|
2015
|
2015 May 19. doi: 10.1111/1753-0407.12314. [Epub ahead of print]
|
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, Huang T, Lee AW, et al.
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Ready-to-Eat Cereal Consumption with Total and Cause-Specific Mortality: Prospective Analysis of 367,442 Individuals.
|
J Am Coll Nutr.
|
2015
|
23:1-7
|
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Chen Y,, Wang T, et al.
|
Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease.
|
Atherosclerosis.
|
2015
|
241(1):145-150.
|
|
Wang T,, Xu Y, et al.
|
Association of Bisphenol A Exposure With Hypertension and Early Macrovascular Diseases in Chinese Adults: A Cross-Sectional Study.
|
Medicine (Baltimore).
|
2015
|
94(43):e1814
|
|
, Ng SS, Bray GA, et al.
|
Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial.
|
J Nutr.
|
2015
|
145(6):1289-94.
|
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Sun JC,, Lu JL, et al; the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal (REACTION) Study group.
|
Associations of depression with impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in Chinese adults.
|
Diabet Med.
|
2015
|
32(7):935-43
|
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Sun JC, Huang XL, Deng XR, Lv XF, Lu JL, Chen YH, Bi YF, Wang WQ,, Ning G.
|
Elevated resting heart rate is associated with dyslipidemia in middle-aged and elderly Chinese.
|
Biomed Environ Sci.
|
2014
|
27(8):601-5.
|
|
,Qi L.
|
Chapter40: Genetics of central obesity.
|
In: Ronald Watson, editors. Nutrition in and Prevention and Treatment of Abdominal Obesity. Elsevier;
|
2014
|
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