- 基本信息
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导师姓名：
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邓炯
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学科代码：
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100100
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性别：
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男
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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jiongdeng@shsmu.edu.cn
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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jiongdeng@shsmu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 81620108022 | 肺干细胞恶性转化的分子机理 | 国家自然科学基金国际合作重大项目 |
2017-01~2021-12
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240万元
| 课题负责人 |
| 2013CB910901 | 赖氨酸残基多种翻译后修饰对蛋白质功能的调控作用 | 国家科技委 973重点基础科研项目 |
2013-01~2016-12
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80万元
| 课题参与人 |
| 91129303 | 肺慢性炎症恶性转化的分子机制 | 国家自然科学基金重大研究计划/重点支持项目 |
2012-01~2015-12
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300万元
| 主要责任人 |
| 10140902100 | 基于Gprc5a-敲除小鼠的肺肿瘤发生机制研究 | 国家自然科学基金/面上项目 |
2011-01~2014-12
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40万元
| 主要责任人 |
- 学术论文
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Liu S*, Ye, D*, Xu D, Liao Y, Zhang L, Liu L, Yu W, Wang Y, He Y, Hu J, Guo W, Wang T, Sun B, Song H, Yin H, Liu J, Wu Y, Zhu H,, Deng J *, Zhang Z*
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Autocrine Epiregulin Activates EGFR Pathway for Lung Metastasis via EMT in Salivary Adenoid Cystic Carcinoma.
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Oncotarget
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2016
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7(18): 25251-63
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Wang X, Xu D, Liao Y, Zhong S, Song H, Sun B, Zhou BP,, Han B,*
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Epithelial Neoplasia Coincides with Exacerbated Injury and Fibrotic Response in the Lungs of Gprc5a-knockout Mice Following Silica Exposure
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Oncotarget
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2015
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6(37):39578-93, 2015
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Liu S, Ye D, Guo W, Yu W, He Y, Hu J, Wang Y, Zhang L, Liao Y, Song H, Zhong S, Xu D, Yin H, Sun B, Wang X, Liu J, Wu Y, Zhou BP*, Zhang Z*,
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G9a is Essential for EMT-mediated Metastasis and Maintenance of Cancer Stem Cell-like Characters in Head and Neck Squamous Cell Carcinoma
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Oncotarget
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2015
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6(9):6887-901
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Zhong S, Yin H, Liao Y, Yao F, Li Q, Zhang J, Jiao H, Zhao Y, Xu D, Liu S, Song H, Gao Y, Liu J, Ma L, Pang Z, Yang R, Ding C, Sun B, Lin X, Ye X, Guo W, Han B, Zhou BP, Chin YE,
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Lung tumor suppressor GPRC5A binds EGFR and restrains its effector signaling
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Cancer Research
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2015
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75(9):1801-1814
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Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W1, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z,, Li QJ, Wang H
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MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3
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Nature Communication
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2015
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6:7639-7651
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Liao Y, Song H, Xu D, Jiao H, Yao F, Liu J, Wu Y, Zhong S, Yin H, Liu S, Wang X, Guo W, Sun B, Han B, Chin YE,
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Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-kappaB pathway
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Cell Cycle
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2015
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14(9):1403-1412
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Lin X, Zhong S, Ye X, Liao Y, Yao F, Yang X, Sun B, Zhang J, Li Q, Gao Y, Wang Y, Liu J, Han B, Chin YE, Zhou BP,
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EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer
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Molecular Cancer
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2014
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13(1):233-244
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Shi J, Wang Y, Zeng L, Wu Y,, Zhang Q, Lin Y, Li J, Kang TB, Tao M, Rusinova E, Zhang GT, Wang C, Zhu H, Yao J, Zeng YX, Evers BM, Zhou MM, Zhou BP
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Disrupting the Interaction of BRD4 with Di-acetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer
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Cancer Cell
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2014
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25(2):210-225
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Shu-li Liu, Shuang-shuang Zhong, Dong-xia Ye, Wan-tao Chen, Zhi-yuan Zhang,
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Repression of G protein–coupled receptor family C group 5 member A is associated with pathologic differentiation grade of oral squamous cell carcinoma
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Journal of Oral Pathology & Medicine
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2013
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42(10):761-768
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Jingyi Liu, Yueling Liao, Kewei Ma, Yonglu Wang, Guoxiang Zhang, Rongcun Yang,
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PI3K is required for the physical interaction and functional inhibition of NF-kappaB by beta-catenin in colorectal cancer cells
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Biochemical and Biophysical Research Communications
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2013
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434(4):760-766
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Chen Y,, Fujimoto J, Kadara H, Men T, Lotan D, Lotan R.
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Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor.
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Cancer Research
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2010
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70(21):8917-26
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, J. Fujimoto, J, Ye, X, Men, T, Van Pelt, CS, Chen, Y, Lin, X, Tao, Q, Lacroix, L, Lee, JJ, Lotan, D, and Lotan, R.
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Gprc5a-knockout leads to NF-kB activation in airway epithelium and promotes lung inflammation and tumorigenesis.
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Cancer Prev Res (Phila Pa)
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2010
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3(4):424-37
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Wu Y,, Rychahou PG, Qia S, Evers MB. and Zhou BP.
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Stabilization of Snail by NF-kB is required for inflammation induced cell migration and invasion.
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Cancer Cell
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2009
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15(5):416-28
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