- 基本信息
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导师姓名：
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张永芳
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学科代码：
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100700
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性别：
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女
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学科名称：
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药学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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硕士生导师
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专业领域名称：
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联系方式：
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专业领域代码：
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邮编：
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邮箱地址：
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13391269883@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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美国神经科学学会会员
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上海市中西医结合学会副秘书长
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中国药理学学会委员
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上海市中西医结合学会青委会常委
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上海实验核医学副主任委员
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- 科研项目
| 81973297 | α7烟碱型乙酰胆碱受体介导的中枢抗炎通路的转录后调节新机制 | 国家自然科学基金 |
2020-01~2023-12
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55万元
| 课题参与人 |
| 19JC1413100 | 基于HDX-MS技术的M1胆碱受体与Gαq/11蛋白偶联障碍的分子机制研究 | 上海市“科技创新行动计划”基础研究领域重点项目 |
2019-11~2022-10
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78万元
| 课题参与人 |
| XD18015 | 异菝葜皂苷元对阿尔茨海默病相关基因的差异调节干预阿尔茨海默病的分子机制 | 上海市高水平地方高校建设项目 |
2018-08~2020-12
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10万元
| 课题负责人 |
| 81573401 | 异菝葜皂苷元治疗阿尔茨海默病的组蛋白乙酰化调控机制研究 | 国家自然科学基金 |
2016-01~2019-12
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64.8万元
| 课题负责人 |
| | 知母皂甙元治疗老年痴呆症的表观遗传学机制 | 教育部留学归国人员基金 |
2013-01~2015-12
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5万元
| 课题负责人 |
| 12YZ038 | 知母皂甙元治疗老年痴呆症的表观遗传学机制 | 上海市教委创新基金 |
2012-01~2014-12
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8万元
| 课题负责人 |
| | 知母皂甙元治疗老年痴呆症的表观遗传学机制 | 上海交通大学晨星计划 |
2011-12~2013-12
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8万元
| 课题负责人 |
| 81001426 | 知母皂甙元在帕金森病中的治疗作用及对神经营养因子GDNF的调控机制 | 国家自然科学基金 |
2011-01~2013-12
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20万元
| 课题负责人 |
| 2R01MH052711-16A2 | MOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTP'S | 美国NIH基金 |
2010-05~2015-12
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344万元
| 子课题负责人 |
| 054038 | 从M受体调节机制探讨知母有效成分治疗老年痴呆的作用机理 | 上海市卫生局,局级课题 |
2006-01~2008-12
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3万元
| 课题负责人 |
- 学术论文
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, Xinyi Xie, Boyu Chen, Lina Pan, Gang Wang
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E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's disease
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Gene & Diseases
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2023
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2023. Apr
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Huang Q,, Li LJ, Dammer EB, Hu YB, Xie XY, Tang R, Li JP, Wang JT, Che XQ, Wang G, Ren RJ.
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Adult-Onset Neuronal Ceroid Lipofuscinosis With a Novel DNAJC5 Mutation Exhibits Aberrant Protein Palmitoylation.
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Front aging neurosci
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2022
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2022. Apr
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Song C,, Huang WY, Shi JY, Huang Q, Jiang MJ, Qiu Y, Wang T, Chen HZ, Wang H
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Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity
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Cell Death Differ.
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2022
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29(2):393-406
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Hu YB,, Ren RJ, Dammer EB, Xie XY, Chen SW, Huang Q, Huang WY, Zhang R, Chen HZ, Wang H , Gang Wang.
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microRNA-425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies
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Aging Cell
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2021
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2021 Sep 12
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Hu YB,, Wang H , Ren RJ, Cui HL, Huang WY, Cheng Q, Chen HZ, Wang G.
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miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease
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Cell Death Dis
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2019
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10(8):589
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He X, Yang S, Zhang R, Hou L, Xu J, Hu Y, Xu R, Wang H,
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Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models.
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Front Cell Neurosci.
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2019
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13:18
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Hu YB, Ren RJ,, Huang Y, Cui HL, Ma C, Qiu WY, Wang H, Cui P, Chen HZ, Wang G.
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Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology
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Aging Cell
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2019
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e13001. doi: 10.1111/acel.13001.
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Shi Y, Huang W, Wang Y, Zhang R, Hou L, Xu J, Qiu Z, Xie Q, Chen H,, Wang H.
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Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice.
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Transl Neurodegener.
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2018
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7：21
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Xia Z, Wang F, Zhou S, Zhang R, Wang F, Huang JH, Wu E,, Hu Y.
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Catalpol protects synaptic proteins from beta-amyloid induced neuron injury and improves cognitive functions in aged rats.
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Oncotarget
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2017
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8(41):69303-69315.
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Yang SS, Zhang R, Wang G,
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The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease.
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Transl Neurodegener
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2017
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;6:19.
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Ren RJ,, Dammer EB, Zhou Y, Wang LL, Liu XH, Feng BL, Jiang GX, Chen SD, Wang G, Cheng Q.
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Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism.
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Mol Neurobiol
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2016
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53(8):5772-81
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Li J, Ding X, Zhang R, Jiang W, Sun X, Xia Z, Wang X, Wu E,, Hu Y.
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Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways.
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neuroscience
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2015
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303:103-14
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Li J, Xia Z, Sun X, Zhang R, Huang G, Hickling R, Xia Z, Hu Y,
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Reversal of dopamine neurons and locomotor ability degeneration in aged rats with smilagenin.
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neuroscience
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2013
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245:90-8
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, Kurup P, Xu J, Nairn AC. and Lombroso PJ
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Reduced levels of tyrosine phosphatase STEP block beta-amyloid-mediated GluA1/GluA2 receptor internalization
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Journal of neurochemistry
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2011
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119(3):664-72
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Kurup P*,, Xu J, Venkitaramani D and Lombroso PJ
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Ab-mediated NMDA receptor endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP61
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J Neurosci.
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2010
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30(17):5948-57
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, Kurup P, Xu J, Carty N, Fernande S, Nygaard H, Pittenger C, Strittmater SM., Nairn AC. and Lombroso PJ.
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Genetic reduction of STEP tyrosine phosphatase reverses cognitive and cellular deficits in a mouse model of Alzheimer’s disease
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Proc Natl Acad Sci U S A
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2010
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107(44):19014-9.
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, Xia Z, Hu Y, Orsi A and Ress D
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Role of glial cell derived neurotrophic factor in the protective effect of smilagenin on rat mesencephalic dopaminergic neurons damaged by MPP+.
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FEBS Lett
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2008
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582:956-60
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